Motif ID: NKX2-6

Z-value: 0.893


Transcription factors associated with NKX2-6:

Gene SymbolEntrez IDGene Name
NKX2-6 ENSG00000180053.6 NKX2-6



Activity profile for motif NKX2-6.

activity profile for motif NKX2-6


Sorted Z-values histogram for motif NKX2-6

Sorted Z-values for motif NKX2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_56757329 4.811 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr8_+_99076750 2.941 ENST00000545282.1
 C8orf47
chromosome 8 open reading frame 47
chr8_+_99076509 2.763 ENST00000318528.3
 C8orf47
chromosome 8 open reading frame 47
chr8_-_133637624 2.611 ENST00000522789.1
 LRRC6
leucine rich repeat containing 6
chr3_-_121379739 2.610 ENST00000428394.2
ENST00000314583.3
 HCLS1

hematopoietic cell-specific Lyn substrate 1

chr11_+_27062860 2.575 ENST00000528583.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_27062502 2.514 ENST00000263182.3
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_27062272 2.445 ENST00000529202.1
ENST00000533566.1
 BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

chr5_-_43412418 2.351 ENST00000537013.1
ENST00000361115.4
 CCL28

chemokine (C-C motif) ligand 28

chr6_+_33043703 2.257 ENST00000418931.2
ENST00000535465.1
 HLA-DPB1

major histocompatibility complex, class II, DP beta 1

chr6_-_110012380 2.178 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
 AK9



adenylate kinase 9



chr16_-_23724518 2.120 ENST00000457008.2
 ERN2
endoplasmic reticulum to nucleus signaling 2
chr3_-_120365866 2.023 ENST00000475447.2
 HGD
homogentisate 1,2-dioxygenase
chr21_-_43735628 1.887 ENST00000291525.10
ENST00000518498.1
 TFF3

trefoil factor 3 (intestinal)

chr16_+_78056412 1.878 ENST00000299642.4
ENST00000575655.1
 CLEC3A

C-type lectin domain family 3, member A

chr7_+_121513143 1.812 ENST00000393386.2
 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr17_-_34329084 1.794 ENST00000536149.1
ENST00000354059.4
 CCL14
CCL15
chemokine (C-C motif) ligand 14
chemokine (C-C motif) ligand 15
chr1_+_64936428 1.786 ENST00000371073.2
ENST00000290039.5
 CACHD1

cache domain containing 1

chr11_+_65265141 1.740 ENST00000534336.1
 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr1_+_20512568 1.729 ENST00000375099.3
 UBXN10
UBX domain protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 4.8 GO:0070986 left/right axis specification(GO:0070986)
0.2 3.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 3.6 GO:0007586 digestion(GO:0007586)
0.0 3.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.2 2.6 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.4 2.4 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.7 2.2 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.2 2.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.3 2.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 1.8 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 1.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.3 1.6 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 1.6 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.2 1.4 GO:0070995 NADPH oxidation(GO:0070995)
0.0 1.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.3 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.4 1.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 1.1 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0036126 sperm flagellum(GO:0036126)
1.0 2.9 GO:0072534 perineuronal net(GO:0072534)
0.0 2.6 GO:0005929 cilium(GO:0005929)
0.4 2.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 2.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.6 GO:0097227 sperm annulus(GO:0097227)
0.1 1.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 1.3 GO:0002177 manchette(GO:0002177)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.0 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.3 0.8 GO:0005715 late recombination nodule(GO:0005715)
0.2 0.8 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 0.5 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.2 0.5 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 4.1 GO:0008009 chemokine activity(GO:0008009)
0.0 4.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 4.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 2.3 GO:0042605 peptide antigen binding(GO:0042605)
0.2 2.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 2.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.6 1.9 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.3 1.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.2 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.3 GO:0030145 manganese ion binding(GO:0030145)
0.1 1.2 GO:0032027 myosin light chain binding(GO:0032027)
0.4 1.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.4 1.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.8 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 0.7 GO:0047726 iron-cytochrome-c reductase activity(GO:0047726)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.8 ST_ADRENERGIC Adrenergic Pathway
0.0 1.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.8 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage