Motif ID: NKX2-8

Z-value: 0.812


Transcription factors associated with NKX2-8:

Gene SymbolEntrez IDGene Name
NKX2-8 ENSG00000136327.6 NKX2-8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_370518310.472.0e-02Click!


Activity profile for motif NKX2-8.

activity profile for motif NKX2-8


Sorted Z-values histogram for motif NKX2-8

Sorted Z-values for motif NKX2-8



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_13349650 2.466 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
 EMP1



epithelial membrane protein 1



chr1_+_120839412 2.211 ENST00000355228.4
 FAM72B
family with sequence similarity 72, member B
chr15_+_40453204 1.846 ENST00000287598.6
ENST00000412359.3
 BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr17_+_76210367 1.778 ENST00000592734.1
ENST00000587746.1
 BIRC5

baculoviral IAP repeat containing 5

chr1_+_152957707 1.571 ENST00000368762.1
 SPRR1A
small proline-rich protein 1A
chr19_-_51336443 1.519 ENST00000598673.1
 KLK15
kallikrein-related peptidase 15
chr14_-_24732403 1.479 ENST00000206765.6
 TGM1
transglutaminase 1
chr17_+_76210267 1.345 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
 BIRC5



baculoviral IAP repeat containing 5



chr8_+_27182862 1.223 ENST00000521164.1
ENST00000346049.5
 PTK2B

protein tyrosine kinase 2 beta

chr19_+_44037546 1.196 ENST00000601282.1
 ZNF575
zinc finger protein 575
chr14_-_24732368 1.179 ENST00000544573.1
 TGM1
transglutaminase 1
chr1_+_154401791 1.042 ENST00000476006.1
 IL6R
interleukin 6 receptor
chr20_+_58296265 0.897 ENST00000395636.2
ENST00000361300.4
 PHACTR3

phosphatase and actin regulator 3

chr20_+_31619454 0.830 ENST00000349552.1
 BPIFB6
BPI fold containing family B, member 6
chr16_+_88872176 0.816 ENST00000569140.1
 CDT1
chromatin licensing and DNA replication factor 1
chr2_+_136289030 0.795 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
 R3HDM1



R3H domain containing 1



chr15_-_70387120 0.739 ENST00000539550.1
 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr11_-_128457446 0.728 ENST00000392668.4
 ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr2_+_101591314 0.727 ENST00000450763.1
 NPAS2
neuronal PAS domain protein 2
chr3_-_53290016 0.724 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
 TKT



transketolase




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.9 2.7 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 2.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.5 GO:0032060 bleb assembly(GO:0032060)
0.5 1.8 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 1.6 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.3 1.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.0 GO:0002384 hepatic immune response(GO:0002384)
0.3 0.8 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.2 0.8 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 0.7 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 0.7 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.2 0.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.7 GO:0030578 PML body organization(GO:0030578)
0.0 0.7 GO:0051775 response to redox state(GO:0051775)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0001533 cornified envelope(GO:0001533)
0.4 3.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 2.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 1.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.5 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 2.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 2.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 2.2 GO:0003823 antigen binding(GO:0003823)
0.1 1.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.4 1.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.8 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.8 GO:0019841 retinol binding(GO:0019841)
0.2 0.7 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 0.7 GO:0004802 transketolase activity(GO:0004802)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.5 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.0 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME_XENOBIOTICS Genes involved in Xenobiotics