Motif ID: NKX2-8

Z-value: 0.812


Transcription factors associated with NKX2-8:

Gene SymbolEntrez IDGene Name
NKX2-8 ENSG00000136327.6 NKX2-8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_370518310.472.0e-02Click!


Activity profile for motif NKX2-8.

activity profile for motif NKX2-8


Sorted Z-values histogram for motif NKX2-8

Sorted Z-values for motif NKX2-8



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13349650 2.466 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1



epithelial membrane protein 1



chr1_+_120839412 2.211 ENST00000355228.4
FAM72B
family with sequence similarity 72, member B
chr15_+_40453204 1.846 ENST00000287598.6
ENST00000412359.3
BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr17_+_76210367 1.778 ENST00000592734.1
ENST00000587746.1
BIRC5

baculoviral IAP repeat containing 5

chr1_+_152957707 1.571 ENST00000368762.1
SPRR1A
small proline-rich protein 1A
chr19_-_51336443 1.519 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr14_-_24732403 1.479 ENST00000206765.6
TGM1
transglutaminase 1
chr17_+_76210267 1.345 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5



baculoviral IAP repeat containing 5



chr8_+_27182862 1.223 ENST00000521164.1
ENST00000346049.5
PTK2B

protein tyrosine kinase 2 beta

chr19_+_44037546 1.196 ENST00000601282.1
ZNF575
zinc finger protein 575
chr14_-_24732368 1.179 ENST00000544573.1
TGM1
transglutaminase 1
chr1_+_154401791 1.042 ENST00000476006.1
IL6R
interleukin 6 receptor
chr20_+_58296265 0.897 ENST00000395636.2
ENST00000361300.4
PHACTR3

phosphatase and actin regulator 3

chr20_+_31619454 0.830 ENST00000349552.1
BPIFB6
BPI fold containing family B, member 6
chr16_+_88872176 0.816 ENST00000569140.1
CDT1
chromatin licensing and DNA replication factor 1
chr2_+_136289030 0.795 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1



R3H domain containing 1



chr15_-_70387120 0.739 ENST00000539550.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr11_-_128457446 0.728 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr2_+_101591314 0.727 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr3_-_53290016 0.724 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
TKT



transketolase



chr14_-_106573756 0.708 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr13_-_23949671 0.701 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_-_107590383 0.679 ENST00000525934.1
ENST00000531293.1
SLN

sarcolipin

chr1_+_10057274 0.676 ENST00000294435.7
RBP7
retinol binding protein 7, cellular
chr12_-_118406777 0.672 ENST00000339824.5
KSR2
kinase suppressor of ras 2
chr3_-_47950745 0.670 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr8_-_62559366 0.664 ENST00000522919.1
ASPH
aspartate beta-hydroxylase
chr1_-_94147385 0.630 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr5_-_78808617 0.618 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1


homer homolog 1 (Drosophila)


chr2_-_36779411 0.596 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr19_+_2249308 0.587 ENST00000592877.1
ENST00000221496.4
AMH

anti-Mullerian hormone

chr14_-_106791536 0.556 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr16_+_8807419 0.546 ENST00000565016.1
ENST00000567812.1
ABAT

4-aminobutyrate aminotransferase

chr11_+_35211429 0.542 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44


CD44 molecule (Indian blood group)


chr6_+_69942298 0.538 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr22_-_50523760 0.515 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_+_111717600 0.514 ENST00000273368.4
TAGLN3
transgelin 3
chr17_-_8055747 0.507 ENST00000317276.4
ENST00000581703.1
PER1

period circadian clock 1

chr6_-_39290744 0.505 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr3_+_111717511 0.497 ENST00000478951.1
ENST00000393917.2
TAGLN3

transgelin 3

chr7_+_135242652 0.497 ENST00000285968.6
ENST00000440390.2
NUP205

nucleoporin 205kDa

chr14_-_107049312 0.491 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr6_+_116782527 0.489 ENST00000368606.3
ENST00000368605.1
FAM26F

family with sequence similarity 26, member F

chr11_+_5410607 0.480 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chrX_-_64196376 0.479 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr17_+_61086917 0.463 ENST00000424789.2
ENST00000389520.4
TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chrX_-_64196307 0.457 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr3_+_47021168 0.453 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2


neurobeachin-like 2


chr20_-_48747662 0.451 ENST00000371656.2
TMEM189
transmembrane protein 189
chr8_-_145018905 0.448 ENST00000398774.2
PLEC
plectin
chr4_-_123377880 0.439 ENST00000226730.4
IL2
interleukin 2
chr7_+_129847688 0.438 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr14_-_106586656 0.437 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr16_+_23194033 0.436 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chrX_-_64196351 0.435 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr10_+_74653330 0.426 ENST00000334011.5
OIT3
oncoprotein induced transcript 3
chr15_-_20170354 0.422 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr19_+_34856141 0.421 ENST00000586425.1
GPI
glucose-6-phosphate isomerase
chr4_-_69111401 0.418 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr4_+_71200681 0.416 ENST00000273936.5
CABS1
calcium-binding protein, spermatid-specific 1
chr4_+_37245799 0.407 ENST00000309447.5
KIAA1239
KIAA1239
chr12_+_9144626 0.397 ENST00000543895.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr7_+_30634297 0.397 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr7_+_73507409 0.394 ENST00000538333.3
LIMK1
LIM domain kinase 1
chr1_+_228337553 0.391 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr12_+_66218903 0.377 ENST00000393577.3
HMGA2
high mobility group AT-hook 2
chr1_+_158223923 0.377 ENST00000289429.5
CD1A
CD1a molecule
chr7_+_112063192 0.371 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr15_-_99057551 0.360 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr5_+_14664762 0.358 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr13_-_46756351 0.358 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_32145861 0.352 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr2_-_46385 0.349 ENST00000327669.4
FAM110C
family with sequence similarity 110, member C
chr7_-_766879 0.336 ENST00000537384.1
ENST00000417852.1
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr14_-_106552755 0.334 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr2_-_136288740 0.330 ENST00000264159.6
ENST00000536680.1
ZRANB3

zinc finger, RAN-binding domain containing 3

chr16_+_58426296 0.330 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3


GINS complex subunit 3 (Psf3 homolog)


chr14_-_106068065 0.326 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr6_+_34433844 0.326 ENST00000244458.2
ENST00000374043.2
PACSIN1

protein kinase C and casein kinase substrate in neurons 1

chr2_-_110371720 0.326 ENST00000356688.4
SEPT10
septin 10
chr14_+_24540046 0.321 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6



copine VI (neuronal)



chr4_-_153601136 0.319 ENST00000504064.1
ENST00000304385.3
TMEM154

transmembrane protein 154

chr14_+_22356029 0.319 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr9_-_21166659 0.316 ENST00000380225.1
IFNA21
interferon, alpha 21
chr3_-_16524357 0.315 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr14_-_107131560 0.312 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr11_+_64808675 0.309 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr16_-_20681177 0.308 ENST00000524149.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr3_-_178984759 0.303 ENST00000349697.2
ENST00000497599.1
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr3_-_116163830 0.303 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr16_+_32077386 0.298 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr12_+_121416489 0.294 ENST00000541395.1
ENST00000544413.1
HNF1A

HNF1 homeobox A

chr1_+_16348525 0.290 ENST00000331433.4
CLCNKA
chloride channel, voltage-sensitive Ka
chr17_-_33390667 0.287 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL


ring finger and FYVE-like domain containing E3 ubiquitin protein ligase


chr16_+_32063311 0.286 ENST00000426099.1
AC142381.1
AC142381.1
chrX_+_41548220 0.278 ENST00000378142.4
GPR34
G protein-coupled receptor 34
chr2_-_106054952 0.276 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2


four and a half LIM domains 2


chrX_+_41548259 0.274 ENST00000378138.5
GPR34
G protein-coupled receptor 34
chr7_-_99277610 0.271 ENST00000343703.5
ENST00000222982.4
ENST00000439761.1
ENST00000339843.2
CYP3A5



cytochrome P450, family 3, subfamily A, polypeptide 5



chr5_-_176056974 0.269 ENST00000510387.1
ENST00000506696.1
SNCB

synuclein, beta

chr3_+_52813932 0.268 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr2_-_29297127 0.265 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chr11_-_72353451 0.264 ENST00000376450.3
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_+_12040238 0.251 ENST00000444836.1
ENST00000235329.5
MFN2

mitofusin 2

chr3_+_52812523 0.249 ENST00000540715.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr16_+_89696692 0.247 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr22_-_32341336 0.246 ENST00000248984.3
C22orf24
chromosome 22 open reading frame 24
chr10_+_71078595 0.243 ENST00000359426.6
HK1
hexokinase 1
chr14_-_58894332 0.241 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr4_-_170947565 0.239 ENST00000506764.1
MFAP3L
microfibrillar-associated protein 3-like
chr6_+_41010293 0.239 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2


translocator protein 2


chr2_-_132249955 0.237 ENST00000309451.6
MZT2A
mitotic spindle organizing protein 2A
chr1_-_95007193 0.236 ENST00000370207.4
ENST00000334047.7
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_155006224 0.236 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr1_-_67266939 0.234 ENST00000304526.2
INSL5
insulin-like 5
chr7_-_36764142 0.232 ENST00000258749.5
ENST00000535891.1
AOAH

acyloxyacyl hydrolase (neutrophil)

chr5_-_101834617 0.225 ENST00000513675.1
ENST00000379807.3
SLCO6A1

solute carrier organic anion transporter family, member 6A1

chr4_+_144303093 0.224 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr1_+_173793777 0.224 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr12_+_66218598 0.221 ENST00000541363.1
HMGA2
high mobility group AT-hook 2
chr12_-_102591604 0.221 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr12_-_11548496 0.218 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2

PRB1
proline-rich protein BstNI subfamily 2

proline-rich protein BstNI subfamily 1
chr14_-_58894223 0.218 ENST00000555593.1
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr13_-_103346854 0.218 ENST00000267273.6
METTL21C
methyltransferase like 21C
chr2_-_68547061 0.217 ENST00000263655.3
CNRIP1
cannabinoid receptor interacting protein 1
chr5_-_101834712 0.214 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1


solute carrier organic anion transporter family, member 6A1


chr19_-_18391708 0.212 ENST00000600972.1
JUND
jun D proto-oncogene
chr20_+_42143136 0.211 ENST00000373134.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr8_+_67405755 0.209 ENST00000521495.1
C8orf46
chromosome 8 open reading frame 46
chr14_-_106692191 0.209 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr1_+_151512775 0.206 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1




tuftelin 1




chr22_+_38609538 0.201 ENST00000407965.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr9_-_22009297 0.199 ENST00000276925.6
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr3_-_53164423 0.196 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1


RFT1 homolog (S. cerevisiae)


chr16_+_33006369 0.194 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr5_+_149737202 0.193 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1









Treacher Collins-Franceschetti syndrome 1









chrX_-_53461288 0.189 ENST00000375298.4
ENST00000375304.5
HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

chr14_-_106963409 0.188 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr3_-_73673991 0.186 ENST00000308537.4
ENST00000263666.4
PDZRN3

PDZ domain containing ring finger 3

chr2_+_207024306 0.183 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2



eukaryotic translation elongation factor 1 beta 2



chr6_-_32806506 0.178 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr1_+_74701062 0.178 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr5_+_74011328 0.172 ENST00000513336.1
HEXB
hexosaminidase B (beta polypeptide)
chr22_+_38453207 0.169 ENST00000404072.3
ENST00000424694.1
PICK1

protein interacting with PRKCA 1

chr14_-_107199464 0.168 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr16_+_33629600 0.168 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr8_+_128426535 0.167 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr3_-_58613323 0.165 ENST00000474531.1
ENST00000465970.1
FAM107A

family with sequence similarity 107, member A

chr14_+_92980111 0.163 ENST00000216487.7
ENST00000557762.1
RIN3

Ras and Rab interactor 3

chr16_-_33647696 0.160 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9

Uncharacterized protein

chr12_+_66218212 0.160 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
HMGA2



high mobility group AT-hook 2



chr9_-_21202204 0.158 ENST00000239347.3
IFNA7
interferon, alpha 7
chr19_-_11347173 0.157 ENST00000587656.1
DOCK6
dedicator of cytokinesis 6
chr9_-_128412696 0.155 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chrX_+_72064690 0.152 ENST00000438696.1
DMRTC1B
DMRT-like family C1B
chr6_+_111408698 0.151 ENST00000368851.5
SLC16A10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr5_+_3596168 0.150 ENST00000302006.3
IRX1
iroquois homeobox 1
chr5_-_78281775 0.147 ENST00000396151.3
ENST00000565165.1
ARSB

arylsulfatase B

chr3_-_196242233 0.143 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr6_-_133084580 0.143 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2


vanin 2


chr12_+_7941989 0.142 ENST00000229307.4
NANOG
Nanog homeobox
chr14_+_22670455 0.140 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr22_-_37213554 0.139 ENST00000443735.1
PVALB
parvalbumin
chr10_-_15762124 0.135 ENST00000378076.3
ITGA8
integrin, alpha 8
chr17_+_71228793 0.134 ENST00000426147.2
C17orf80
chromosome 17 open reading frame 80
chr2_-_207024134 0.133 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1


NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)


chr9_-_28670283 0.128 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr17_+_39994032 0.125 ENST00000293303.4
ENST00000438813.1
KLHL10

kelch-like family member 10

chr13_+_46039037 0.124 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr2_+_119699864 0.122 ENST00000541757.1
ENST00000412481.1
MARCO

macrophage receptor with collagenous structure

chr2_+_119699742 0.117 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr16_+_29674540 0.117 ENST00000449759.1
ENST00000436527.1
ENST00000360121.3
QPRT
SPN

quinolinate phosphoribosyltransferase
sialophorin

chr2_-_55277692 0.114 ENST00000394611.2
RTN4
reticulon 4
chr4_+_15341442 0.112 ENST00000397700.2
ENST00000295297.4
C1QTNF7

C1q and tumor necrosis factor related protein 7

chr3_+_67048721 0.112 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8



kelch repeat and BTB (POZ) domain containing 8



chr1_+_224301787 0.110 ENST00000366862.5
ENST00000424254.2
FBXO28

F-box protein 28

chr14_-_106845789 0.109 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr14_-_106622419 0.109 ENST00000390604.2
IGHV3-16
immunoglobulin heavy variable 3-16 (non-functional)
chr8_+_24241789 0.109 ENST00000256412.4
ENST00000538205.1
ADAMDEC1

ADAM-like, decysin 1

chr3_-_139195350 0.107 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr2_-_55277654 0.106 ENST00000337526.6
ENST00000317610.7
ENST00000357732.4
RTN4


reticulon 4


chr18_-_13915530 0.105 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr12_-_5352315 0.103 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr16_+_33020496 0.103 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr18_-_73139589 0.101 ENST00000382638.3
ENST00000584508.1
ENST00000579022.1
SMIM21


small integral membrane protein 21


chr4_+_141264597 0.101 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC


short coiled-coil protein


chr12_-_75603643 0.100 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr2_-_207023918 0.099 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1


NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)


chr12_-_21810765 0.098 ENST00000450584.1
ENST00000350669.1
LDHB

lactate dehydrogenase B

chr6_+_125524785 0.097 ENST00000392482.2
TPD52L1
tumor protein D52-like 1
chr12_-_95397442 0.095 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12


NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12


chr22_-_30925150 0.095 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr9_-_21239978 0.093 ENST00000380222.2
IFNA14
interferon, alpha 14
chr17_-_46703826 0.093 ENST00000550387.1
ENST00000311177.5
HOXB9

homeobox B9

chrX_-_110039286 0.090 ENST00000434224.1
CHRDL1
chordin-like 1
chr12_-_75603482 0.090 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr12_+_60058458 0.089 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_141810634 0.089 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2


protein tyrosine kinase 2


chr10_-_118032697 0.089 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr12_-_21810726 0.086 ENST00000396076.1
LDHB
lactate dehydrogenase B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.5 1.8 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 1.0 GO:0002384 hepatic immune response(GO:0002384)
0.3 1.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 0.8 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.2 0.7 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 0.2 GO:0002543 activation of blood coagulation via clotting cascade(GO:0002543)
0.2 0.7 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.2 0.6 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 0.8 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.2 0.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.4 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.1 0.5 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 3.1 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.6 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 0.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.1 0.3 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.1 2.5 GO:0032060 bleb assembly(GO:0032060)
0.1 0.7 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.2 GO:0016999 antibiotic metabolic process(GO:0016999)
0.1 0.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.5 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.3 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.5 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.3 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.2 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 0.3 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.2 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.2 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 2.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.7 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0007619 courtship behavior(GO:0007619)
0.0 0.1 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.5 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 0.4 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0001807 regulation of type IV hypersensitivity(GO:0001807) negative regulation of type IV hypersensitivity(GO:0001808)
0.0 1.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 1.6 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.5 GO:0030220 platelet formation(GO:0030220)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 1.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.0 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.0 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:1902306 negative regulation of sodium ion transmembrane transport(GO:1902306)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.3 1.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.5 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 1.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 0.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 4.2 GO:0001533 cornified envelope(GO:0001533)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 2.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.3 2.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.7 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 0.8 GO:0035501 MH1 domain binding(GO:0035501)
0.2 0.7 GO:0004802 transketolase activity(GO:0004802)
0.1 0.4 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.1 0.5 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 1.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.2 GO:0032093 SAM domain binding(GO:0032093)
0.1 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.1 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.4 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 2.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.4 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.8 GO:0019841 retinol binding(GO:0019841)
0.0 0.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.2 GO:0003823 antigen binding(GO:0003823)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST_STAT3_PATHWAY STAT3 Pathway
0.1 3.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.8 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis