Motif ID: NKX3-1

Z-value: 0.907


Transcription factors associated with NKX3-1:

Gene SymbolEntrez IDGene Name
NKX3-1 ENSG00000167034.9 NKX3-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-1hg19_v2_chr8_-_23540402_23540466-0.648.5e-04Click!


Activity profile for motif NKX3-1.

activity profile for motif NKX3-1


Sorted Z-values histogram for motif NKX3-1

Sorted Z-values for motif NKX3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153113927 3.436 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr1_-_153066998 3.236 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr10_+_118187379 2.925 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_107681633 2.538 ENST00000394872.2
ENST00000334504.7
COL4A6

collagen, type IV, alpha 6

chr5_+_150404904 2.414 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr1_-_153085984 2.248 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr18_+_61445007 2.201 ENST00000447428.1
ENST00000546027.1
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr19_+_16308711 2.184 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr6_-_39290316 2.182 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16



potassium channel, subfamily K, member 16



chr5_+_68485433 2.156 ENST00000502689.1
CENPH
centromere protein H
chr6_+_24775641 2.008 ENST00000378054.2
ENST00000476555.1
GMNN

geminin, DNA replication inhibitor

chr2_+_102456277 1.983 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr19_-_14889349 1.971 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
EMR2




egf-like module containing, mucin-like, hormone receptor-like 2




chr20_-_56285595 1.797 ENST00000395816.3
ENST00000347215.4
PMEPA1

prostate transmembrane protein, androgen induced 1

chr19_-_11266471 1.776 ENST00000592540.1
SPC24
SPC24, NDC80 kinetochore complex component
chr11_-_62323702 1.770 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr20_-_56286479 1.721 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_+_16308659 1.716 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr5_+_96211643 1.715 ENST00000437043.3
ENST00000510373.1
ERAP2

endoplasmic reticulum aminopeptidase 2

chr19_-_44174330 1.694 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0018149 peptide cross-linking(GO:0018149)
0.2 3.9 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 3.7 GO:0030574 collagen catabolic process(GO:0030574)
0.3 3.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 3.3 GO:0051382 kinetochore assembly(GO:0051382)
0.6 3.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.6 2.5 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.4 2.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 2.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.6 2.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 2.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.1 GO:0030033 microvillus assembly(GO:0030033)
0.3 2.0 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.6 1.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 1.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 1.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 1.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.5 1.5 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 GO:0001533 cornified envelope(GO:0001533)
0.1 6.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 4.2 GO:0035580 specific granule lumen(GO:0035580)
0.0 3.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 3.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.6 GO:0000786 nucleosome(GO:0000786)
0.3 2.5 GO:0005587 collagen type IV trimer(GO:0005587)
0.2 2.5 GO:0071438 invadopodium membrane(GO:0071438)
0.2 2.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.8 GO:0031262 Ndc80 complex(GO:0031262)
0.2 1.7 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.4 1.5 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0050699 WW domain binding(GO:0050699)
0.2 3.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.5 3.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 3.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 2.5 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 2.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 2.0 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.0 GO:0008430 selenium binding(GO:0008430)
0.0 2.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.9 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 1.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 4.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.1 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 3.9 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.3 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 2.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.0 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi