Motif ID: NKX3-1
Z-value: 0.907

Transcription factors associated with NKX3-1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NKX3-1 | ENSG00000167034.9 | NKX3-1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NKX3-1 | hg19_v2_chr8_-_23540402_23540466 | -0.64 | 8.5e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 112 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 7.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
0.2 | 3.9 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
0.0 | 3.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.3 | 3.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.2 | 3.3 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.6 | 3.2 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
0.6 | 2.5 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
0.4 | 2.4 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
0.5 | 2.3 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
0.6 | 2.2 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
0.1 | 2.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.1 | 2.1 | GO:0030033 | microvillus assembly(GO:0030033) |
0.3 | 2.0 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
0.6 | 1.8 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
0.0 | 1.8 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
0.1 | 1.7 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
0.0 | 1.7 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.0 | 1.7 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
0.2 | 1.6 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
0.5 | 1.5 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 52 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 9.1 | GO:0001533 | cornified envelope(GO:0001533) |
0.1 | 6.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 4.2 | GO:0035580 | specific granule lumen(GO:0035580) |
0.0 | 3.3 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
0.0 | 3.3 | GO:0031901 | early endosome membrane(GO:0031901) |
0.0 | 2.6 | GO:0000786 | nucleosome(GO:0000786) |
0.3 | 2.5 | GO:0005587 | collagen type IV trimer(GO:0005587) |
0.2 | 2.5 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.2 | 2.0 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.3 | 1.8 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.2 | 1.7 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
0.0 | 1.6 | GO:0005882 | intermediate filament(GO:0005882) |
0.4 | 1.5 | GO:0030934 | anchoring collagen complex(GO:0030934) |
0.1 | 1.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 1.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.1 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.0 | 1.4 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.0 | 1.4 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
0.0 | 1.4 | GO:0005901 | caveola(GO:0005901) |
0.1 | 1.0 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 85 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.4 | GO:0050699 | WW domain binding(GO:0050699) |
0.2 | 3.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.5 | 3.3 | GO:0043515 | kinetochore binding(GO:0043515) |
0.1 | 3.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.1 | 3.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.8 | 2.5 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
0.0 | 2.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 2.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
0.1 | 2.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.2 | 2.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.2 | 2.0 | GO:0008430 | selenium binding(GO:0008430) |
0.0 | 2.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.1 | 1.9 | GO:0044548 | S100 protein binding(GO:0044548) |
0.0 | 1.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.1 | 1.7 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 1.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 1.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.5 | 1.5 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.3 | 1.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
Gene overrepresentation in C2:CP category:
Showing 1 to 19 of 19 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 4.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 3.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.1 | 2.5 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.0 | 1.9 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.0 | 1.9 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.0 | 1.8 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
0.0 | 1.6 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
0.0 | 1.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 1.5 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
0.1 | 1.4 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 1.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 1.1 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 1.0 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 0.9 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.5 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 0.4 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.0 | 0.1 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 36 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.7 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.1 | 5.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.2 | 3.9 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.1 | 3.9 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.1 | 3.2 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 3.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.1 | 2.3 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
0.1 | 2.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.1 | 2.0 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
0.0 | 2.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 1.7 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.0 | 1.5 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.0 | 1.5 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.1 | 1.4 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 1.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.1 | 1.0 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 1.0 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
0.0 | 1.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 0.9 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
0.0 | 0.8 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |