Motif ID: NKX3-2

Z-value: 1.286


Transcription factors associated with NKX3-2:

Gene SymbolEntrez IDGene Name
NKX3-2 ENSG00000109705.7 NKX3-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v2_chr4_-_13546632_13546674-0.252.4e-01Click!


Activity profile for motif NKX3-2.

activity profile for motif NKX3-2


Sorted Z-values histogram for motif NKX3-2

Sorted Z-values for motif NKX3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_112970436 9.746 ENST00000400613.4
 C9orf152
chromosome 9 open reading frame 152
chr1_-_161337662 8.757 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr9_-_34397800 8.176 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr5_-_149792295 6.129 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr6_-_32557610 5.743 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr17_-_74137374 5.556 ENST00000322957.6
 FOXJ1
forkhead box J1
chr7_-_99573677 5.503 ENST00000292401.4
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_34458771 5.475 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr13_+_43355683 5.307 ENST00000537894.1
 FAM216B
family with sequence similarity 216, member B
chr13_+_43355732 5.281 ENST00000313851.1
 FAM216B
family with sequence similarity 216, member B
chr11_-_111175739 4.386 ENST00000532918.1
 COLCA1
colorectal cancer associated 1
chr6_+_32821924 3.754 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr16_-_21289627 3.675 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr1_-_183622442 3.646 ENST00000308641.4
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr5_+_156696362 3.574 ENST00000377576.3
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_98703643 3.530 ENST00000477737.1
 VWA3B
von Willebrand factor A domain containing 3B
chr19_+_41497178 3.397 ENST00000324071.4
 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr17_+_68071389 3.278 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr16_+_57406368 3.241 ENST00000006053.6
ENST00000563383.1
 CX3CL1

chemokine (C-X3-C motif) ligand 1

chr11_-_26593649 3.205 ENST00000455601.2
 MUC15
mucin 15, cell surface associated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.4 8.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 7.9 GO:0016266 O-glycan processing(GO:0016266)
0.2 6.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 6.2 GO:0010107 potassium ion import(GO:0010107)
1.2 6.1 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.6 6.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.1 5.7 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 5.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
1.9 5.6 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 5.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.3 5.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.4 5.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 3.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 3.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 3.5 GO:0031295 T cell costimulation(GO:0031295)
1.1 3.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.8 3.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 2.8 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.2 2.5 GO:0042738 exogenous drug catabolic process(GO:0042738)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 7.8 GO:0043235 receptor complex(GO:0043235)
0.4 7.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.9 6.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.5 5.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 5.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 3.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 3.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.4 2.9 GO:1990393 3M complex(GO:1990393)
0.6 2.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 2.5 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.4 1.8 GO:0031213 RSF complex(GO:0031213)
0.1 1.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.2 GO:0070695 FHF complex(GO:0070695)
0.1 1.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 1.2 GO:0030286 dynein complex(GO:0030286)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.1 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.3 8.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.0 6.9 GO:0050682 AF-2 domain binding(GO:0050682)
1.2 6.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 5.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 5.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 5.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 5.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 3.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 3.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.2 3.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.6 3.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 3.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 2.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 2.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 2.8 GO:0030332 cyclin binding(GO:0030332)
0.2 2.4 GO:0032395 MHC class II receptor activity(GO:0032395)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 7.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 6.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 5.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 5.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 4.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.7 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2 3.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 3.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 2.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 2.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.2 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY Genes involved in Costimulation by the CD28 family
0.0 1.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.4 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.1 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels