Motif ID: NKX6-2

Z-value: 0.625


Transcription factors associated with NKX6-2:

Gene SymbolEntrez IDGene Name
NKX6-2 ENSG00000148826.6 NKX6-2



Activity profile for motif NKX6-2.

activity profile for motif NKX6-2


Sorted Z-values histogram for motif NKX6-2

Sorted Z-values for motif NKX6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_7921090 1.974 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_23891658 1.041 ENST00000507380.1
 PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_88896819 0.986 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
 SPP1



secreted phosphoprotein 1



chr7_+_123241908 0.947 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
 ASB15


ankyrin repeat and SOCS box containing 15


chr1_+_244515930 0.856 ENST00000366537.1
ENST00000308105.4
 C1orf100

chromosome 1 open reading frame 100

chr2_+_210444142 0.660 ENST00000360351.4
ENST00000361559.4
 MAP2

microtubule-associated protein 2

chr3_-_141747950 0.646 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_+_31193847 0.640 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr14_-_98444461 0.620 ENST00000499006.2
 C14orf64
chromosome 14 open reading frame 64
chr4_+_169013666 0.607 ENST00000359299.3
 ANXA10
annexin A10
chr12_+_32655110 0.589 ENST00000546442.1
ENST00000583694.1
 FGD4

FYVE, RhoGEF and PH domain containing 4

chrX_+_135230712 0.558 ENST00000535737.1
 FHL1
four and a half LIM domains 1
chr2_+_11864458 0.548 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
 LPIN1


lipin 1


chr1_+_209878182 0.529 ENST00000367027.3
 HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr18_-_19994830 0.502 ENST00000525417.1
 CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr3_+_39509163 0.479 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
 MOBP


myelin-associated oligodendrocyte basic protein


chr10_+_32873190 0.478 ENST00000375025.4
 C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr2_-_208030647 0.421 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_110933611 0.417 ENST00000472422.2
ENST00000437429.2
 SLC16A4

solute carrier family 16, member 4

chr1_-_110933663 0.412 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
 SLC16A4


solute carrier family 16, member 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 1.0 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.8 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.5 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.4 GO:0007412 axon target recognition(GO:0007412)
0.1 0.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.3 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 0.2 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.2 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 0.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.4 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 0.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine