Motif ID: NKX6-3

Z-value: 0.227


Transcription factors associated with NKX6-3:

Gene SymbolEntrez IDGene Name
NKX6-3 ENSG00000165066.11 NKX6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41504878_41504878-0.301.5e-01Click!


Activity profile for motif NKX6-3.

activity profile for motif NKX6-3


Sorted Z-values histogram for motif NKX6-3

Sorted Z-values for motif NKX6-3



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_125133315 0.543 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr5_-_139726181 0.376 ENST00000507104.1
ENST00000230990.6
 HBEGF

heparin-binding EGF-like growth factor

chr9_+_125132803 0.369 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_141747950 0.316 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chrX_+_43515467 0.313 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chr6_+_130339710 0.295 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr9_+_124329336 0.228 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
 DAB2IP


DAB2 interacting protein


chrX_+_107288239 0.212 ENST00000217957.5
 VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_208417620 0.207 ENST00000367033.3
 PLXNA2
plexin A2
chr6_+_114178512 0.203 ENST00000368635.4
 MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_+_107288197 0.177 ENST00000415430.3
 VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_13517565 0.168 ENST00000282091.1
ENST00000529816.1
 PTH

parathyroid hormone

chr19_+_4402659 0.138 ENST00000301280.5
ENST00000585854.1
 CHAF1A

chromatin assembly factor 1, subunit A (p150)

chr15_+_93443419 0.131 ENST00000557381.1
ENST00000420239.2
 CHD2

chromodomain helicase DNA binding protein 2

chr17_-_64225508 0.119 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr16_-_67517716 0.114 ENST00000290953.2
 AGRP
agouti related protein homolog (mouse)
chr1_-_204183071 0.095 ENST00000308302.3
 GOLT1A
golgi transport 1A
chr14_-_51027838 0.084 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr15_+_92006567 0.078 ENST00000554333.1
 RP11-661P17.1
RP11-661P17.1
chr17_-_10372875 0.068 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chr10_+_18549645 0.059 ENST00000396576.2
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_+_121902511 0.056 ENST00000490131.1
 CASR
calcium-sensing receptor
chr12_-_52761262 0.052 ENST00000257901.3
 KRT85
keratin 85
chr20_+_30697298 0.052 ENST00000398022.2
 TM9SF4
transmembrane 9 superfamily protein member 4
chr3_+_136649311 0.048 ENST00000469404.1
ENST00000467911.1
 NCK1

NCK adaptor protein 1

chr6_-_9933500 0.043 ENST00000492169.1
 OFCC1
orofacial cleft 1 candidate 1
chr7_+_129984630 0.043 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
 CPA5








carboxypeptidase A5








chr3_-_141719195 0.041 ENST00000397991.4
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr8_+_77593474 0.033 ENST00000455469.2
ENST00000050961.6
 ZFHX4

zinc finger homeobox 4

chr20_-_33735070 0.032 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr8_+_77593448 0.031 ENST00000521891.2
 ZFHX4
zinc finger homeobox 4
chr13_-_81801115 0.026 ENST00000567258.1
 LINC00564
long intergenic non-protein coding RNA 564
chr4_+_80584903 0.021 ENST00000506460.1
 RP11-452C8.1
RP11-452C8.1
chr20_-_29978286 0.016 ENST00000376315.2
 DEFB119
defensin, beta 119
chr5_-_142780280 0.014 ENST00000424646.2
 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr4_+_76481258 0.005 ENST00000311623.4
ENST00000435974.2
 C4orf26

chromosome 4 open reading frame 26

chr8_+_92261516 0.004 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.0 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.0 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.1 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion