Motif ID: NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 0.632

Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1:

Gene SymbolEntrez IDGene Name
DLX2 ENSG00000115844.6 DLX2
DLX6 ENSG00000006377.9 DLX6
NKX6-1 ENSG00000163623.5 NKX6-1
NOTO ENSG00000214513.3 NOTO
VSX2 ENSG00000119614.2 VSX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DLX2hg19_v2_chr2_-_172967621_1729676370.537.2e-03Click!
DLX6hg19_v2_chr7_+_96635277_96635301,
hg19_v2_chr7_+_96634850_96634874		-0.262.2e-01Click!
NKX6-1hg19_v2_chr4_-_85419603_854196030.145.1e-01Click!


Activity profile for motif NOTO_VSX2_DLX2_DLX6_NKX6-1.

activity profile for motif NOTO_VSX2_DLX2_DLX6_NKX6-1


Sorted Z-values histogram for motif NOTO_VSX2_DLX2_DLX6_NKX6-1

Sorted Z-values for motif NOTO_VSX2_DLX2_DLX6_NKX6-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_36050881 3.085 ENST00000537702.1
 NBEA
neurobeachin
chr17_-_39203519 2.723 ENST00000542137.1
ENST00000391419.3
 KRTAP2-1

keratin associated protein 2-1

chr6_-_87804815 2.321 ENST00000369582.2
 CGA
glycoprotein hormones, alpha polypeptide
chr7_-_25268104 1.794 ENST00000222674.2
 NPVF
neuropeptide VF precursor
chr1_-_183622442 1.621 ENST00000308641.4
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr8_-_10512569 1.385 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr20_-_7921090 1.268 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_76203345 1.242 ENST00000393004.2
 FILIP1
filamin A interacting protein 1
chr4_-_138453606 1.224 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18



protocadherin 18



chr6_-_76203454 1.211 ENST00000237172.7
 FILIP1
filamin A interacting protein 1
chr2_-_68052694 1.157 ENST00000457448.1
 AC010987.6
AC010987.6
chr2_-_145278475 1.138 ENST00000558170.2
 ZEB2
zinc finger E-box binding homeobox 2
chr11_-_31531121 1.101 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
 IMMP1L






IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)






chr20_-_50419055 1.098 ENST00000217086.4
 SALL4
spalt-like transcription factor 4
chr12_-_16761007 0.983 ENST00000354662.1
ENST00000441439.2
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr16_+_53133070 0.976 ENST00000565832.1
 CHD9
chromodomain helicase DNA binding protein 9
chr16_-_28621353 0.940 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr12_+_54378923 0.940 ENST00000303460.4
 HOXC10
homeobox C10
chr14_-_92413727 0.896 ENST00000267620.10
 FBLN5
fibulin 5
chr1_+_183774240 0.890 ENST00000360851.3
 RGL1
ral guanine nucleotide dissociation stimulator-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 1.9 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 1.9 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.6 GO:0072189 ureter development(GO:0072189)
0.1 1.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 1.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.0 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 0.9 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.9 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.9 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.9 GO:0007595 lactation(GO:0007595)
0.0 0.9 GO:0007585 respiratory gaseous exchange(GO:0007585)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0045095 keratin filament(GO:0045095)
0.0 2.9 GO:0043209 myelin sheath(GO:0043209)
0.0 2.8 GO:0005796 Golgi lumen(GO:0005796)
0.3 2.5 GO:0071953 elastic fiber(GO:0071953)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.7 GO:0000792 heterochromatin(GO:0000792)
0.0 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 0.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.9 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.9 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.9 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.5 GO:0031904 endosome lumen(GO:0031904)
0.1 0.4 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4 1.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 1.3 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 1.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.0 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1 0.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.9 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.7 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.1 0.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate