Motif ID: NR0B1

Z-value: 0.596


Transcription factors associated with NR0B1:

Gene SymbolEntrez IDGene Name
NR0B1 ENSG00000169297.6 NR0B1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR0B1hg19_v2_chrX_-_30327495_30327509,
hg19_v2_chrX_-_30326445_30326605		-0.424.2e-02Click!


Activity profile for motif NR0B1.

activity profile for motif NR0B1


Sorted Z-values histogram for motif NR0B1

Sorted Z-values for motif NR0B1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR0B1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_29595779 0.726 ENST00000355973.3
ENST00000377012.4
 GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr12_+_50355647 0.684 ENST00000293599.6
 AQP5
aquaporin 5
chrX_+_130192318 0.512 ENST00000370922.1
 ARHGAP36
Rho GTPase activating protein 36
chrX_+_130192216 0.449 ENST00000276211.5
 ARHGAP36
Rho GTPase activating protein 36
chr1_-_46598371 0.420 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
 PIK3R3




phosphoinositide-3-kinase, regulatory subunit 3 (gamma)




chr1_-_46598284 0.394 ENST00000423209.1
ENST00000262741.5
 PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr2_+_234545148 0.370 ENST00000373445.1
 UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr8_-_100025238 0.362 ENST00000521696.1
 RP11-410L14.2
RP11-410L14.2
chr1_+_26146397 0.355 ENST00000374303.2
ENST00000533762.1
ENST00000529116.1
ENST00000474295.1
ENST00000488327.2
ENST00000472643.1
ENST00000526894.1
ENST00000524618.1
ENST00000374307.5
 MTFR1L








mitochondrial fission regulator 1-like








chrX_-_128788914 0.325 ENST00000429967.1
ENST00000307484.6
 APLN

apelin

chr3_-_183979251 0.313 ENST00000296238.3
 CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr1_-_40098672 0.313 ENST00000535435.1
 HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr1_+_26146674 0.308 ENST00000525713.1
ENST00000374301.3
 MTFR1L

mitochondrial fission regulator 1-like

chr20_-_3996165 0.302 ENST00000545616.2
ENST00000358395.6
 RNF24

ring finger protein 24

chr1_-_223537401 0.299 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
 SUSD4


sushi domain containing 4


chr7_+_89841024 0.292 ENST00000394626.1
 STEAP2
STEAP family member 2, metalloreductase
chr5_+_110559603 0.288 ENST00000512453.1
 CAMK4
calcium/calmodulin-dependent protein kinase IV
chr7_+_89841144 0.287 ENST00000394622.2
ENST00000394632.1
ENST00000426158.1
ENST00000394621.2
ENST00000402625.2
 STEAP2




STEAP family member 2, metalloreductase




chr19_-_49576198 0.281 ENST00000221444.1
 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr14_-_61190754 0.279 ENST00000216513.4
 SIX4
SIX homeobox 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 0.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.7 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.7 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.3 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.3 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.3 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.3 GO:0016598 protein arginylation(GO:0016598)
0.0 0.3 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.1 0.2 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.2 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.1 0.2 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 0.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.3 GO:0034706 sodium channel complex(GO:0034706)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.2 GO:1990923 PET complex(GO:1990923)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 0.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.7 GO:0015250 water channel activity(GO:0015250)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.6 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.4 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.4 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 0.3 GO:0004057 arginyltransferase activity(GO:0004057)
0.0 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease