Motif ID: NR1H2

Z-value: 0.533


Transcription factors associated with NR1H2:

Gene SymbolEntrez IDGene Name
NR1H2 ENSG00000131408.9 NR1H2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1H2hg19_v2_chr19_+_50879705_50879775-0.242.6e-01Click!


Activity profile for motif NR1H2.

activity profile for motif NR1H2


Sorted Z-values histogram for motif NR1H2

Sorted Z-values for motif NR1H2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_234104079 2.017 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_+_113735575 1.273 ENST00000376489.2
ENST00000259205.4
 IL36G

interleukin 36, gamma

chr7_-_76247617 1.254 ENST00000441393.1
 POMZP3
POM121 and ZP3 fusion
chr22_+_30792846 1.199 ENST00000312932.9
ENST00000428195.1
 SEC14L2

SEC14-like 2 (S. cerevisiae)

chr17_-_76183111 0.910 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
 TK1



thymidine kinase 1, soluble



chr1_-_113478603 0.893 ENST00000443580.1
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr11_+_844406 0.842 ENST00000397404.1
 TSPAN4
tetraspanin 4
chr7_+_153584166 0.639 ENST00000404039.1
 DPP6
dipeptidyl-peptidase 6
chr1_+_10290822 0.620 ENST00000377083.1
 KIF1B
kinesin family member 1B
chr6_-_144385698 0.594 ENST00000444202.1
ENST00000437412.1
 PLAGL1

pleiomorphic adenoma gene-like 1

chr4_-_39033963 0.540 ENST00000381938.3
 TMEM156
transmembrane protein 156
chr15_-_63674218 0.534 ENST00000178638.3
 CA12
carbonic anhydrase XII
chr1_-_237167718 0.511 ENST00000464121.2
 MT1HL1
metallothionein 1H-like 1
chr11_+_86748998 0.459 ENST00000525018.1
ENST00000355734.4
 TMEM135

transmembrane protein 135

chr9_-_107690420 0.444 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
 ABCA1


ATP-binding cassette, sub-family A (ABC1), member 1


chr3_+_39371255 0.433 ENST00000414803.1
ENST00000545843.1
 CCR8

chemokine (C-C motif) receptor 8

chr16_+_88704978 0.431 ENST00000244241.4
 IL17C
interleukin 17C
chr12_+_22778116 0.428 ENST00000538218.1
 ETNK1
ethanolamine kinase 1
chr4_+_5526883 0.426 ENST00000195455.2
 C4orf6
chromosome 4 open reading frame 6
chr6_+_30687978 0.416 ENST00000327892.8
ENST00000435534.1
 TUBB

tubulin, beta class I


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.2 1.3 GO:0035803 egg coat formation(GO:0035803)
0.0 1.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.3 0.9 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.2 0.9 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 0.8 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.7 GO:0032094 response to food(GO:0032094)
0.2 0.6 GO:1904647 response to rotenone(GO:1904647)
0.0 0.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.5 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 0.5 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.4 GO:0015917 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.4 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 0.3 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.3 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.3 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.3 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.3 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.0 GO:0031085 BLOC-3 complex(GO:0031085)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 1.3 GO:0032190 acrosin binding(GO:0032190)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 1.2 GO:0008431 vitamin E binding(GO:0008431)
0.2 1.1 GO:0004882 androgen receptor activity(GO:0004882)
0.3 0.9 GO:0004797 thymidine kinase activity(GO:0004797)
0.3 0.9 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.3 0.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.2 0.5 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.4 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.3 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.1 0.3 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)