Motif ID: NR1H4

Z-value: 0.555


Transcription factors associated with NR1H4:

Gene SymbolEntrez IDGene Name
NR1H4 ENSG00000012504.9 NR1H4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1H4hg19_v2_chr12_+_100897130_1008972310.472.1e-02Click!


Activity profile for motif NR1H4.

activity profile for motif NR1H4


Sorted Z-values histogram for motif NR1H4

Sorted Z-values for motif NR1H4



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_106449862 2.223 ENST00000372453.3
ENST00000535523.1
 PIH1D3

PIH1 domain containing 3

chr9_-_34381536 1.938 ENST00000379126.3
ENST00000379127.1
ENST00000379133.3
 C9orf24


chromosome 9 open reading frame 24


chr9_-_34381511 1.894 ENST00000379124.1
 C9orf24
chromosome 9 open reading frame 24
chr3_-_50383096 1.722 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr14_-_65769392 1.463 ENST00000555736.1
 CTD-2509G16.5
CTD-2509G16.5
chrX_+_152338301 1.426 ENST00000453825.2
 PNMA6A
paraneoplastic Ma antigen family member 6A
chr9_-_138391692 1.403 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr13_+_31506818 1.328 ENST00000380473.3
 TEX26
testis expressed 26
chr19_+_50706866 1.212 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
 MYH14




myosin, heavy chain 14, non-muscle




chr7_-_131241361 0.992 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like



chr5_-_16509101 0.923 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B
chr19_-_50311896 0.848 ENST00000529634.2
 FUZ
fuzzy planar cell polarity protein
chr20_-_62462566 0.835 ENST00000245663.4
ENST00000302995.2
 ZBTB46

zinc finger and BTB domain containing 46

chr5_-_139944196 0.719 ENST00000357560.4
 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr5_-_139943830 0.666 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
 APBB3





amyloid beta (A4) precursor protein-binding, family B, member 3





chr11_+_45868957 0.661 ENST00000443527.2
 CRY2
cryptochrome 2 (photolyase-like)
chr16_-_67700594 0.606 ENST00000602644.1
ENST00000243878.4
 ENKD1

enkurin domain containing 1

chr1_+_162351503 0.598 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr19_+_35629702 0.584 ENST00000351325.4
 FXYD1
FXYD domain containing ion transport regulator 1
chr8_-_101321584 0.537 ENST00000523167.1
 RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 1.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 1.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 1.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 1.0 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.2 0.8 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1 0.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.2 0.7 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.2 0.7 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.6 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.5 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.5 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 0.4 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.4 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.1 0.3 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0034451 centriolar satellite(GO:0034451)
0.2 1.2 GO:0097513 myosin II filament(GO:0097513)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.4 GO:0042627 chylomicron(GO:0042627)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.2 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.4 GO:0035473 lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.3 GO:0016918 retinal binding(GO:0016918)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.3 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway