Motif ID: NR1I2

Z-value: 0.577


Transcription factors associated with NR1I2:

Gene SymbolEntrez IDGene Name
NR1I2 ENSG00000144852.12 NR1I2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1I2hg19_v2_chr3_+_119501557_119501557-0.193.7e-01Click!


Activity profile for motif NR1I2.

activity profile for motif NR1I2


Sorted Z-values histogram for motif NR1I2

Sorted Z-values for motif NR1I2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1I2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_94833642 1.015 ENST00000224356.4
ENST00000394139.1
 CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

chr20_-_52790512 0.871 ENST00000216862.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr1_+_218519577 0.724 ENST00000366930.4
ENST00000366929.4
 TGFB2

transforming growth factor, beta 2

chr4_-_120243545 0.672 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr11_-_111783595 0.669 ENST00000528628.1
 CRYAB
crystallin, alpha B
chr17_+_7942424 0.611 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr2_+_30454390 0.560 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
 LBH


limb bud and heart development


chr20_+_3776371 0.558 ENST00000245960.5
 CDC25B
cell division cycle 25B
chr1_+_74701062 0.552 ENST00000326637.3
 TNNI3K
TNNI3 interacting kinase
chr20_+_3776936 0.520 ENST00000439880.2
 CDC25B
cell division cycle 25B
chr9_+_33795533 0.510 ENST00000379405.3
 PRSS3
protease, serine, 3
chr2_-_235405168 0.506 ENST00000339728.3
 ARL4C
ADP-ribosylation factor-like 4C
chrX_+_135279179 0.487 ENST00000370676.3
 FHL1
four and a half LIM domains 1
chr19_-_51472222 0.486 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr12_-_95510743 0.457 ENST00000551521.1
 FGD6
FYVE, RhoGEF and PH domain containing 6
chr4_-_159094194 0.449 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
 FAM198B


family with sequence similarity 198, member B


chrX_+_135278908 0.448 ENST00000539015.1
ENST00000370683.1
 FHL1

four and a half LIM domains 1

chrX_-_72299258 0.412 ENST00000453389.1
ENST00000373519.1
 PABPC1L2A

poly(A) binding protein, cytoplasmic 1-like 2A

chr2_+_114256661 0.409 ENST00000306507.5
 FOXD4L1
forkhead box D4-like 1
chr15_-_81616446 0.404 ENST00000302824.6
 STARD5
StAR-related lipid transfer (START) domain containing 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.1 1.1 GO:0007144 female meiosis I(GO:0007144)
0.3 1.0 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.3 0.9 GO:0042369 vitamin D catabolic process(GO:0042369)
0.0 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 0.7 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) negative regulation of alkaline phosphatase activity(GO:0010693) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.6 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.1 0.6 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.5 GO:0060356 leucine import(GO:0060356)
0.0 0.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.4 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.4 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 0.4 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.4 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.4 GO:0097443 sorting endosome(GO:0097443)
0.1 0.3 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.1 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 0.6 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0031013 troponin I binding(GO:0031013)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.4 GO:0032052 bile acid binding(GO:0032052)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0031432 titin binding(GO:0031432)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins