Motif ID: NR1I3

Z-value: 0.363


Transcription factors associated with NR1I3:

Gene SymbolEntrez IDGene Name
NR1I3 ENSG00000143257.7 NR1I3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1I3hg19_v2_chr1_-_161208013_161208092,
hg19_v2_chr1_-_161207953_161207975
-0.311.3e-01Click!


Activity profile for motif NR1I3.

activity profile for motif NR1I3


Sorted Z-values histogram for motif NR1I3

Sorted Z-values for motif NR1I3



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1I3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_32407619 1.567 ENST00000395388.2
ENST00000374982.5
HLA-DRA

major histocompatibility complex, class II, DR alpha

chrX_-_15619076 0.727 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr9_-_75567962 0.528 ENST00000297785.3
ENST00000376939.1
ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr5_+_156712372 0.525 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_26036093 0.476 ENST00000374329.1
MAN1C1
mannosidase, alpha, class 1C, member 1
chr12_+_53817633 0.456 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
AMHR2


anti-Mullerian hormone receptor, type II


chr1_-_20126365 0.423 ENST00000294543.6
ENST00000375122.2
TMCO4

transmembrane and coiled-coil domains 4

chr12_-_108991812 0.243 ENST00000392806.3
ENST00000547567.1
TMEM119

transmembrane protein 119

chr1_-_23886285 0.222 ENST00000374561.5
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr17_-_34270668 0.217 ENST00000293274.4
LYZL6
lysozyme-like 6
chr17_-_34270697 0.214 ENST00000585556.1
LYZL6
lysozyme-like 6
chr6_-_56258892 0.209 ENST00000370819.1
COL21A1
collagen, type XXI, alpha 1
chr9_+_75766763 0.209 ENST00000456643.1
ENST00000415424.1
ANXA1

annexin A1

chr6_+_33422343 0.192 ENST00000395064.2
ZBTB9
zinc finger and BTB domain containing 9
chr11_+_63137251 0.191 ENST00000310969.4
ENST00000279178.3
SLC22A9

solute carrier family 22 (organic anion transporter), member 9

chrX_+_128872998 0.188 ENST00000371106.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr16_+_30710462 0.178 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP


Snf2-related CREBBP activator protein


chr7_+_101460882 0.176 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1




cut-like homeobox 1




chr1_+_15250596 0.173 ENST00000361144.5
KAZN
kazrin, periplakin interacting protein
chr17_+_32582293 0.166 ENST00000580907.1
ENST00000225831.4
CCL2

chemokine (C-C motif) ligand 2

chr19_-_6604094 0.148 ENST00000597430.2
CD70
CD70 molecule
chr11_-_82611448 0.133 ENST00000393399.2
ENST00000313010.3
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr20_+_5987890 0.131 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr16_+_53133070 0.126 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr16_-_16317321 0.125 ENST00000205557.7
ENST00000575728.1
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr9_+_124048864 0.122 ENST00000545652.1
GSN
gelsolin
chr4_+_70894130 0.117 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3


histatin 3


chr1_-_1690014 0.116 ENST00000400922.2
ENST00000342348.5
NADK

NAD kinase

chr19_-_7562334 0.115 ENST00000593942.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr16_-_4465886 0.114 ENST00000539968.1
CORO7
coronin 7
chr1_+_32930647 0.112 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr1_+_145516252 0.107 ENST00000369306.3
PEX11B
peroxisomal biogenesis factor 11 beta
chr1_+_153330322 0.105 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr1_+_145516560 0.104 ENST00000537888.1
PEX11B
peroxisomal biogenesis factor 11 beta
chr16_+_67906919 0.102 ENST00000358933.5
EDC4
enhancer of mRNA decapping 4
chr19_-_49140692 0.102 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chrX_+_69674943 0.100 ENST00000542398.1
DLG3
discs, large homolog 3 (Drosophila)
chr14_+_22977587 0.099 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr15_+_43985084 0.099 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr15_+_43885252 0.098 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr9_-_80646374 0.097 ENST00000286548.4
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr17_-_62502639 0.095 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DDX5



DEAD (Asp-Glu-Ala-Asp) box helicase 5



chr1_+_160097462 0.090 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr15_+_96875657 0.087 ENST00000559679.1
ENST00000394171.2
NR2F2

nuclear receptor subfamily 2, group F, member 2

chr14_+_22748980 0.087 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr1_-_151119087 0.084 ENST00000341697.3
ENST00000368914.3
SEMA6C

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr17_-_8198636 0.084 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35


solute carrier family 25, member 35


chr4_-_57524061 0.082 ENST00000508121.1
HOPX
HOP homeobox
chr3_-_50396978 0.073 ENST00000266025.3
TMEM115
transmembrane protein 115
chr18_-_19283649 0.070 ENST00000584464.1
ENST00000578270.1
ABHD3

abhydrolase domain containing 3

chr17_-_26694979 0.070 ENST00000438614.1
VTN
vitronectin
chr17_-_26695013 0.069 ENST00000555059.2
CTB-96E2.2
Homeobox protein SEBOX
chr15_+_96876340 0.068 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_62502399 0.066 ENST00000450599.2
ENST00000585060.1
DDX5

DEAD (Asp-Glu-Ala-Asp) box helicase 5

chr4_+_37245799 0.066 ENST00000309447.5
KIAA1239
KIAA1239
chr1_-_32210275 0.060 ENST00000440175.2
BAI2
brain-specific angiogenesis inhibitor 2
chr1_-_205290865 0.059 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr19_-_9968816 0.059 ENST00000590841.1
OLFM2
olfactomedin 2
chr11_-_57089671 0.058 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr3_-_58419537 0.054 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB



pyruvate dehydrogenase (lipoamide) beta



chr1_-_149900122 0.050 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr5_-_135528822 0.050 ENST00000607574.1
AC009014.3
AC009014.3
chr19_-_49140609 0.050 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr20_+_62339381 0.048 ENST00000355969.6
ENST00000357119.4
ENST00000431125.1
ENST00000369967.3
ENST00000328969.5
ZGPAT




zinc finger, CCCH-type with G patch domain




chr2_-_86790472 0.047 ENST00000409727.1
CHMP3
charged multivesicular body protein 3
chr20_+_57766075 0.045 ENST00000371030.2
ZNF831
zinc finger protein 831
chr11_+_62556596 0.045 ENST00000526546.1
TMEM179B
transmembrane protein 179B
chr1_-_155159748 0.044 ENST00000473363.2
RP11-201K10.3
RP11-201K10.3
chr10_+_88414338 0.038 ENST00000241891.5
ENST00000443292.1
OPN4

opsin 4

chr20_-_23549334 0.035 ENST00000376979.3
CST9L
cystatin 9-like
chr13_-_20806440 0.035 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6


gap junction protein, beta 6, 30kDa


chr18_-_19284724 0.034 ENST00000580981.1
ENST00000289119.2
ABHD3

abhydrolase domain containing 3

chr7_-_99381798 0.033 ENST00000415003.1
ENST00000354593.2
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr8_-_109799793 0.031 ENST00000297459.3
TMEM74
transmembrane protein 74
chr3_+_122103014 0.030 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
FAM162A


family with sequence similarity 162, member A


chr9_-_91793675 0.026 ENST00000375835.4
ENST00000375830.1
SHC3

SHC (Src homology 2 domain containing) transforming protein 3

chr5_-_176937351 0.026 ENST00000377112.4
ENST00000501403.2
ENST00000312943.6
DOK3


docking protein 3


chr16_+_577697 0.025 ENST00000562370.1
ENST00000568988.1
ENST00000219611.2
CAPN15


calpain 15


chr2_-_86790593 0.024 ENST00000263856.4
ENST00000409225.2
CHMP3

charged multivesicular body protein 3

chr11_-_104480019 0.015 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1


RP11-886D15.1


chr1_-_27682962 0.015 ENST00000486046.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr6_+_108487245 0.014 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr13_+_60971080 0.013 ENST00000377894.2
TDRD3
tudor domain containing 3
chr9_+_35605274 0.012 ENST00000336395.5
TESK1
testis-specific kinase 1
chr14_+_53173890 0.012 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr14_+_53173910 0.012 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6


proteasome (prosome, macropain) 26S subunit, ATPase, 6


chr15_+_85523671 0.009 ENST00000310298.4
ENST00000557957.1
PDE8A

phosphodiesterase 8A

chr16_-_66968055 0.008 ENST00000568572.1
FAM96B
family with sequence similarity 96, member B
chr22_+_42372764 0.008 ENST00000396426.3
ENST00000406029.1
SEPT3

septin 3

chr2_-_128642434 0.007 ENST00000393001.1
AMMECR1L
AMMECR1-like
chr11_+_105480740 0.007 ENST00000393125.2
GRIA4
glutamate receptor, ionotropic, AMPA 4
chr10_-_50396425 0.006 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr12_+_57998400 0.006 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
DTX3



deltex homolog 3 (Drosophila)



chr6_-_34113856 0.006 ENST00000538487.2
GRM4
glutamate receptor, metabotropic 4
chr11_-_89609185 0.004 ENST00000329862.6
TRIM64B
tripartite motif containing 64B
chr14_-_77787198 0.003 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chrX_-_39186610 0.001 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2

RP11-265P11.2

chr12_-_75601778 0.001 ENST00000550433.1
ENST00000548513.1
KCNC2

potassium voltage-gated channel, Shaw-related subfamily, member 2

chrX_-_110655391 0.001 ENST00000356915.2
ENST00000356220.3
DCX

doublecortin

chr1_-_33336414 0.000 ENST00000373471.3
ENST00000609187.1
FNDC5

fibronectin type III domain containing 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.7 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.5 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.5 GO:1902613 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 0.5 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.2 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.1 0.2 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.1 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.2 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0031313 extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 1.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.7 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation