Motif ID: NR2E1

Z-value: 0.813


Transcription factors associated with NR2E1:

Gene SymbolEntrez IDGene Name
NR2E1 ENSG00000112333.7 NR2E1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR2E1hg19_v2_chr6_+_108487245_1084872620.242.5e-01Click!


Activity profile for motif NR2E1.

activity profile for motif NR2E1


Sorted Z-values histogram for motif NR2E1

Sorted Z-values for motif NR2E1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR2E1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_91539918 2.217 ENST00000548218.1
 DCN
decorin
chr2_-_31637560 1.740 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr5_-_11588907 1.659 ENST00000513598.1
ENST00000503622.1
 CTNND2

catenin (cadherin-associated protein), delta 2

chr2_+_113885138 1.467 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr1_-_205419053 1.444 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr4_-_47983519 1.271 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
 CNGA1


cyclic nucleotide gated channel alpha 1


chr5_-_11589131 1.242 ENST00000511377.1
 CTNND2
catenin (cadherin-associated protein), delta 2
chr1_+_32042105 1.190 ENST00000457433.2
ENST00000441210.2
 TINAGL1

tubulointerstitial nephritis antigen-like 1

chr18_+_29027696 1.169 ENST00000257189.4
 DSG3
desmoglein 3
chr11_-_62323702 1.120 ENST00000530285.1
 AHNAK
AHNAK nucleoprotein
chr4_-_111119804 1.062 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr11_-_63439381 1.038 ENST00000538786.1
ENST00000540699.1
 ATL3

atlastin GTPase 3

chr10_+_11784360 1.021 ENST00000379215.4
ENST00000420401.1
 ECHDC3

enoyl CoA hydratase domain containing 3

chr17_-_41623691 0.954 ENST00000545954.1
 ETV4
ets variant 4
chr12_-_82152444 0.931 ENST00000549325.1
ENST00000550584.2
 PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr4_+_71063641 0.889 ENST00000514097.1
 ODAM
odontogenic, ameloblast asssociated
chr14_+_22977587 0.825 ENST00000390504.1
 TRAJ33
T cell receptor alpha joining 33
chr12_-_91572278 0.799 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
 DCN



decorin



chr11_-_63439013 0.791 ENST00000398868.3
 ATL3
atlastin GTPase 3
chr7_-_107443652 0.754 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
 SLC26A3


solute carrier family 26 (anion exchanger), member 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 2.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 2.6 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.4 1.7 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 1.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 1.5 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 1.5 GO:0014047 glutamate secretion(GO:0014047)
0.1 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.3 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 1.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 1.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 1.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.9 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 0.9 GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.2 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.8 GO:0021615 rhombomere development(GO:0021546) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.8 GO:0019532 oxalate transport(GO:0019532)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 2.6 GO:0043204 perikaryon(GO:0043204)
0.1 2.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.5 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.1 1.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.2 0.7 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.5 GO:0008013 beta-catenin binding(GO:0008013)
0.3 2.3 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.5 1.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.3 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.8 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 0.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 0.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.7 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.1 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.4 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.4 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.4 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification