Motif ID: NR2E3

Z-value: 0.427


Transcription factors associated with NR2E3:

Gene SymbolEntrez IDGene Name
NR2E3 ENSG00000031544.10 NR2E3



Activity profile for motif NR2E3.

activity profile for motif NR2E3


Sorted Z-values histogram for motif NR2E3

Sorted Z-values for motif NR2E3



Network of associatons between targets according to the STRING database.



First level regulatory network of NR2E3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_1633755 0.804 ENST00000545662.1
 WDR81
WD repeat domain 81
chr1_+_47264711 0.594 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr2_-_216257849 0.584 ENST00000456923.1
 FN1
fibronectin 1
chrX_-_132887729 0.490 ENST00000406757.2
 GPC3
glypican 3
chr3_-_195310802 0.455 ENST00000421243.1
ENST00000453131.1
 APOD

apolipoprotein D

chr17_+_12692774 0.437 ENST00000379672.5
ENST00000340825.3
 ARHGAP44

Rho GTPase activating protein 44

chr20_+_56725952 0.437 ENST00000371168.3
 C20orf85
chromosome 20 open reading frame 85
chr8_+_40010989 0.436 ENST00000315792.3
 C8orf4
chromosome 8 open reading frame 4
chr4_-_110723134 0.434 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr4_-_110723194 0.432 ENST00000394635.3
 CFI
complement factor I
chr11_-_108408895 0.406 ENST00000443411.1
ENST00000533052.1
 EXPH5

exophilin 5

chr4_-_110723335 0.398 ENST00000394634.2
 CFI
complement factor I
chr1_-_146697185 0.365 ENST00000533174.1
ENST00000254090.4
 FMO5

flavin containing monooxygenase 5

chr3_-_186262166 0.357 ENST00000307944.5
 CRYGS
crystallin, gamma S
chr17_+_68165657 0.348 ENST00000243457.3
 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr4_+_189060573 0.345 ENST00000332517.3
 TRIML1
tripartite motif family-like 1
chr22_-_36013368 0.323 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
 MB



myoglobin



chr17_-_6735035 0.312 ENST00000338694.2
 TEKT1
tektin 1
chr17_-_6735012 0.309 ENST00000535086.1
 TEKT1
tektin 1
chr12_+_56661461 0.301 ENST00000546544.1
ENST00000553234.1
 COQ10A

coenzyme Q10 homolog A (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0072189 ureter development(GO:0072189)
0.2 0.6 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.6 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.6 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 0.5 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.4 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.4 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.4 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.3 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0030849 autosome(GO:0030849)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0072517 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.0 GO:0035841 new growing cell tip(GO:0035841)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.6 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.5 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.3 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.1 0.2 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor