Motif ID: NR4A1

Z-value: 0.531


Transcription factors associated with NR4A1:

Gene SymbolEntrez IDGene Name
NR4A1 ENSG00000123358.15 NR4A1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A1hg19_v2_chr12_+_52445191_524452430.396.3e-02Click!


Activity profile for motif NR4A1.

activity profile for motif NR4A1


Sorted Z-values histogram for motif NR4A1

Sorted Z-values for motif NR4A1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_63638339 5.240 ENST00000343837.3
ENST00000469440.1
SNTN

sentan, cilia apical structure protein

chr18_-_24722995 1.712 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr1_+_104293028 1.339 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr20_+_31755934 1.310 ENST00000354932.5
BPIFA2
BPI fold containing family A, member 2
chr1_+_212738676 1.010 ENST00000366981.4
ENST00000366987.2
ATF3

activating transcription factor 3

chr9_-_75567962 0.965 ENST00000297785.3
ENST00000376939.1
ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr1_+_61869748 0.768 ENST00000357977.5
NFIA
nuclear factor I/A
chr9_+_1051481 0.680 ENST00000358146.2
ENST00000259622.6
DMRT2

doublesex and mab-3 related transcription factor 2

chr11_+_7618413 0.662 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_108868390 0.653 ENST00000372101.2
KCNE1L
KCNE1-like
chr5_+_73109339 0.604 ENST00000296799.4
ARHGEF28
Rho guanine nucleotide exchange factor (GEF) 28
chr1_+_16062820 0.603 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr2_-_25194963 0.600 ENST00000264711.2
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr12_+_109577202 0.599 ENST00000377848.3
ENST00000377854.5
ACACB

acetyl-CoA carboxylase beta

chr6_-_152489484 0.579 ENST00000354674.4
ENST00000539504.1
SYNE1

spectrin repeat containing, nuclear envelope 1

chr16_+_53241854 0.574 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_111743285 0.559 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr19_+_13134772 0.547 ENST00000587760.1
ENST00000585575.1
NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr22_+_24891210 0.524 ENST00000382760.2
UPB1
ureidopropionase, beta
chr3_+_184055240 0.514 ENST00000383847.2
FAM131A
family with sequence similarity 131, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.3 GO:0019730 antimicrobial humoral response(GO:0019730)
0.3 1.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 1.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 0.8 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.8 GO:0072189 ureter development(GO:0072189)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.7 GO:0061055 myotome development(GO:0061055)
0.1 0.6 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.4 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.3 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.3 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.0 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.7 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 1.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 1.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.1 0.6 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0035173 histone kinase activity(GO:0035173)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0004530 ribonuclease III activity(GO:0004525) deoxyribonuclease I activity(GO:0004530) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.3 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.1 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.0 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism