Motif ID: NR4A2

Z-value: 0.497


Transcription factors associated with NR4A2:

Gene SymbolEntrez IDGene Name
NR4A2 ENSG00000153234.9 NR4A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A2hg19_v2_chr2_-_157198860_1571989780.735.5e-05Click!


Activity profile for motif NR4A2.

activity profile for motif NR4A2


Sorted Z-values histogram for motif NR4A2

Sorted Z-values for motif NR4A2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_149792295 2.127 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr16_-_67427389 2.029 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr2_+_120189422 1.612 ENST00000306406.4
 TMEM37
transmembrane protein 37
chr20_+_31755934 1.134 ENST00000354932.5
 BPIFA2
BPI fold containing family A, member 2
chr1_-_104238912 0.981 ENST00000330330.5
 AMY1B
amylase, alpha 1B (salivary)
chr1_-_104239076 0.964 ENST00000370080.3
 AMY1B
amylase, alpha 1B (salivary)
chr19_+_35629702 0.895 ENST00000351325.4
 FXYD1
FXYD domain containing ion transport regulator 1
chr4_+_41614909 0.813 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
 LIMCH1


LIM and calponin homology domains 1


chr6_+_149068464 0.679 ENST00000367463.4
 UST
uronyl-2-sulfotransferase
chr4_+_15471489 0.627 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A








coiled-coil and C2 domain containing 2A








chr2_-_27712583 0.597 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
 IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr22_+_32149927 0.585 ENST00000437411.1
ENST00000535622.1
ENST00000536766.1
ENST00000400242.3
ENST00000266091.3
ENST00000400249.2
ENST00000400246.1
ENST00000382105.2
 DEPDC5







DEP domain containing 5







chr11_+_66624527 0.581 ENST00000393952.3
 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr1_-_226129083 0.528 ENST00000420304.2
 LEFTY2
left-right determination factor 2
chr22_-_37880543 0.526 ENST00000442496.1
 MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr10_+_81107271 0.521 ENST00000448165.1
 PPIF
peptidylprolyl isomerase F
chr1_-_226129189 0.518 ENST00000366820.5
 LEFTY2
left-right determination factor 2
chr22_-_27620603 0.507 ENST00000418271.1
ENST00000444114.1
 RP5-1172A22.1

RP5-1172A22.1

chr1_+_196621156 0.464 ENST00000359637.2
 CFH
complement factor H
chr12_-_81992111 0.454 ENST00000443686.3
ENST00000407050.4
 PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0046785 microtubule polymerization(GO:0046785)
0.4 2.1 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 1.1 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 1.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.3 0.9 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.9 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.7 GO:0006477 protein sulfation(GO:0006477)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.6 GO:0061525 hindgut development(GO:0061525)
0.0 0.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 0.4 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.3 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 2.0 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 0.6 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.6 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.3 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.2 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.2 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.2 GO:0070470 plasma membrane respiratory chain(GO:0070470)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 1.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.5 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.4 GO:0004040 amidase activity(GO:0004040)
0.0 0.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0035173 histone kinase activity(GO:0035173)
0.1 0.3 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 0.3 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.2 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 1.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi