Motif ID: NR5A2

Z-value: 1.378


Transcription factors associated with NR5A2:

Gene SymbolEntrez IDGene Name
NR5A2 ENSG00000116833.9 NR5A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR5A2hg19_v2_chr1_+_199996702_199996732-0.077.4e-01Click!


Activity profile for motif NR5A2.

activity profile for motif NR5A2


Sorted Z-values histogram for motif NR5A2

Sorted Z-values for motif NR5A2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_58152524 3.399 ENST00000359926.3
 PHACTR3
phosphatase and actin regulator 3
chr10_+_118187379 2.821 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr20_+_58179582 2.262 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr3_-_122102065 1.743 ENST00000479899.1
ENST00000291458.5
ENST00000497726.1
 CCDC58


coiled-coil domain containing 58


chr11_+_66059339 1.623 ENST00000327259.4
 TMEM151A
transmembrane protein 151A
chr2_+_135011731 1.493 ENST00000281923.2
 MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr4_-_74864386 1.459 ENST00000296027.4
 CXCL5
chemokine (C-X-C motif) ligand 5
chr1_+_152881014 1.416 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr8_-_110704014 1.383 ENST00000529190.1
ENST00000422135.1
ENST00000419099.1
 SYBU


syntabulin (syntaxin-interacting)


chr1_-_146696901 1.348 ENST00000369272.3
ENST00000441068.2
 FMO5

flavin containing monooxygenase 5

chr5_-_134914673 1.347 ENST00000512158.1
 CXCL14
chemokine (C-X-C motif) ligand 14
chr20_+_42086525 1.263 ENST00000244020.3
 SRSF6
serine/arginine-rich splicing factor 6
chr5_-_54281407 1.222 ENST00000381403.4
 ESM1
endothelial cell-specific molecule 1
chr9_-_130637244 1.219 ENST00000373156.1
 AK1
adenylate kinase 1
chr22_+_31518938 1.211 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
 INPP5J






inositol polyphosphate-5-phosphatase J






chr3_-_58652523 1.205 ENST00000489857.1
ENST00000358781.2
 FAM3D

family with sequence similarity 3, member D

chr1_-_146697185 1.153 ENST00000533174.1
ENST00000254090.4
 FMO5

flavin containing monooxygenase 5

chr6_-_97345689 1.103 ENST00000316149.7
 NDUFAF4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr10_+_102891048 1.096 ENST00000467928.2
 TLX1
T-cell leukemia homeobox 1
chr10_+_81107271 1.071 ENST00000448165.1
 PPIF
peptidylprolyl isomerase F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 3.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 3.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.6 3.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 3.0 GO:0070126 mitochondrial translational termination(GO:0070126)
0.1 2.8 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.2 2.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 2.0 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 2.0 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.2 1.9 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 1.7 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.2 1.7 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 1.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 1.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 1.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.5 1.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.2 1.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 1.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 1.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.7 GO:0030426 growth cone(GO:0030426)
0.0 3.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 3.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 2.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 2.0 GO:0097433 dense body(GO:0097433)
0.0 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.6 GO:0001533 cornified envelope(GO:0001533)
0.1 1.5 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.2 1.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.4 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.4 GO:0070469 respiratory chain(GO:0070469)
0.4 1.3 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0 1.2 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.1 2.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 2.4 GO:0005125 cytokine activity(GO:0005125)
0.3 2.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 1.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.6 1.7 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.2 1.7 GO:0035473 lipase binding(GO:0035473)
0.2 1.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 1.7 GO:0015266 protein channel activity(GO:0015266)
0.5 1.6 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 1.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 2.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.3 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 1.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.8 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 1.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.7 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors