Motif ID: NR6A1

Z-value: 0.716


Transcription factors associated with NR6A1:

Gene SymbolEntrez IDGene Name
NR6A1 ENSG00000148200.12 NR6A1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR6A1hg19_v2_chr9_-_127533519_1275335760.377.4e-02Click!


Activity profile for motif NR6A1.

activity profile for motif NR6A1


Sorted Z-values histogram for motif NR6A1

Sorted Z-values for motif NR6A1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_41620335 3.498 ENST00000331105.2
 CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr4_-_7044657 3.376 ENST00000310085.4
 CCDC96
coiled-coil domain containing 96
chr5_+_94727048 2.781 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr21_+_42694732 2.410 ENST00000398646.3
 FAM3B
family with sequence similarity 3, member B
chr16_+_777118 2.075 ENST00000562141.1
 HAGHL
hydroxyacylglutathione hydrolase-like
chr17_+_4981535 1.797 ENST00000318833.3
 ZFP3
ZFP3 zinc finger protein
chr10_-_61513146 1.768 ENST00000430431.1
 LINC00948
long intergenic non-protein coding RNA 948
chrY_-_21906623 1.691 ENST00000382806.2
 KDM5D
lysine (K)-specific demethylase 5D
chr7_+_23719749 1.529 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
 FAM221A



family with sequence similarity 221, member A



chr14_-_106642049 1.513 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr4_+_39184024 1.495 ENST00000399820.3
ENST00000509560.1
ENST00000512112.1
ENST00000288634.7
ENST00000506503.1
 WDR19




WD repeat domain 19




chr11_+_111789580 1.427 ENST00000278601.5
 C11orf52
chromosome 11 open reading frame 52
chr10_-_61513201 1.393 ENST00000414264.1
ENST00000594536.1
 LINC00948

long intergenic non-protein coding RNA 948

chr5_-_41213607 1.325 ENST00000337836.5
ENST00000433294.1
 C6

complement component 6

chr11_-_108464465 1.300 ENST00000525344.1
 EXPH5
exophilin 5
chr22_-_30867973 1.293 ENST00000402286.1
ENST00000401751.1
ENST00000539629.1
ENST00000403066.1
ENST00000215812.4
 SEC14L3




SEC14-like 3 (S. cerevisiae)




chr2_-_60780607 1.213 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
 BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr20_+_31749574 1.203 ENST00000253362.2
 BPIFA2
BPI fold containing family A, member 2
chr11_-_108464321 1.144 ENST00000265843.4
 EXPH5
exophilin 5
chr19_-_9006766 1.120 ENST00000599436.1
 MUC16
mucin 16, cell surface associated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 2.4 GO:0003334 keratinocyte development(GO:0003334)
0.6 2.3 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 2.1 GO:0016266 O-glycan processing(GO:0016266)
0.7 2.0 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.2 1.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 1.6 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.4 1.5 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 1.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 1.3 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.4 1.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.2 1.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 1.0 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125)
0.0 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 0.9 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.9 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.9 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0 0.9 GO:0015671 oxygen transport(GO:0015671)
0.0 0.9 GO:0034587 piRNA metabolic process(GO:0034587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.5 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.3 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.9 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 0.9 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.9 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.3 0.8 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.8 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.8 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 0.7 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 GO:0070330 aromatase activity(GO:0070330)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.6 GO:0019239 deaminase activity(GO:0019239)
0.5 1.4 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.0 1.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.3 1.0 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.2 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.0 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 1.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.0 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 1.0 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 0.9 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.2 0.9 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.9 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.9 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.9 GO:0008173 RNA methyltransferase activity(GO:0008173)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 2.3 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 2.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)