Motif ID: NRF1

Z-value: 3.105


Transcription factors associated with NRF1:

Gene SymbolEntrez IDGene Name
NRF1 ENSG00000106459.10 NRF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NRF1hg19_v2_chr7_+_129251531_1292516010.786.0e-06Click!


Activity profile for motif NRF1.

activity profile for motif NRF1


Sorted Z-values histogram for motif NRF1

Sorted Z-values for motif NRF1



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_7044657 13.422 ENST00000310085.4
 CCDC96
coiled-coil domain containing 96
chr17_+_260097 13.123 ENST00000360127.6
ENST00000571106.1
ENST00000491373.1
 C17orf97


chromosome 17 open reading frame 97


chr2_-_99757977 12.766 ENST00000355053.4
 TSGA10
testis specific, 10
chr9_+_124922171 12.754 ENST00000373764.3
ENST00000536616.1
 MORN5

MORN repeat containing 5

chr2_-_99757876 9.017 ENST00000539964.1
ENST00000393482.3
 TSGA10

testis specific, 10

chr20_-_35580104 7.515 ENST00000373694.5
 SAMHD1
SAM domain and HD domain 1
chr3_+_49449636 7.278 ENST00000273590.3
 TCTA
T-cell leukemia translocation altered
chr5_+_10441970 7.225 ENST00000274134.4
 ROPN1L
rhophilin associated tail protein 1-like
chr20_-_35580240 7.225 ENST00000262878.4
 SAMHD1
SAM domain and HD domain 1
chr17_-_6735035 6.356 ENST00000338694.2
 TEKT1
tektin 1
chr17_-_6735012 6.320 ENST00000535086.1
 TEKT1
tektin 1
chr1_+_111888890 6.258 ENST00000369738.4
 PIFO
primary cilia formation
chr1_+_111889212 6.256 ENST00000369737.4
 PIFO
primary cilia formation
chr2_+_228736321 6.072 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr16_+_84178874 5.707 ENST00000378553.5
 DNAAF1
dynein, axonemal, assembly factor 1
chr3_-_50383096 5.697 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr2_+_228736335 5.362 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr16_+_80574854 5.183 ENST00000305904.6
ENST00000568035.1
 DYNLRB2

dynein, light chain, roadblock-type 2

chr7_+_149597 5.020 ENST00000484550.1
ENST00000479592.1
ENST00000471299.1
 AC093627.10


AC093627.10


chr10_+_134145735 4.989 ENST00000368613.4
 LRRC27
leucine rich repeat containing 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 492 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.2 GO:0042073 intraciliary transport(GO:0042073)
2.9 14.7 GO:0006203 dGTP catabolic process(GO:0006203)
0.8 13.1 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 12.1 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 11.6 GO:0007283 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.2 10.9 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 10.9 GO:0043687 post-translational protein modification(GO:0043687)
0.4 9.5 GO:0003341 cilium movement(GO:0003341)
0.6 8.5 GO:0006108 malate metabolic process(GO:0006108)
0.7 8.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.6 7.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
2.5 7.4 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.2 7.3 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.4 6.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.3 6.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.8 5.8 GO:0098535 de novo centriole assembly(GO:0098535)
1.0 5.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.7 5.7 GO:0036159 inner dynein arm assembly(GO:0036159)
1.4 5.5 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
1.4 5.4 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 48.8 GO:0031514 motile cilium(GO:0031514)
0.2 22.9 GO:0036064 ciliary basal body(GO:0036064)
0.2 13.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.2 10.8 GO:0036157 outer dynein arm(GO:0036157)
0.6 10.5 GO:0036038 MKS complex(GO:0036038)
0.2 9.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 8.7 GO:0005929 cilium(GO:0005929)
0.4 8.4 GO:0097225 sperm midpiece(GO:0097225)
2.0 8.0 GO:0016939 kinesin II complex(GO:0016939)
0.1 7.6 GO:0045171 intercellular bridge(GO:0045171)
0.1 7.4 GO:0005814 centriole(GO:0005814)
0.2 6.8 GO:0016580 Sin3 complex(GO:0016580)
0.6 6.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.5 6.5 GO:0044666 MLL3/4 complex(GO:0044666)
1.2 6.1 GO:0098536 deuterosome(GO:0098536)
0.3 5.2 GO:0090543 Flemming body(GO:0090543)
0.1 5.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.8 GO:0034451 centriolar satellite(GO:0034451)
0.9 4.7 GO:0005879 axonemal microtubule(GO:0005879)
0.7 4.6 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 298 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 14.6 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.3 12.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 11.5 GO:0045504 dynein heavy chain binding(GO:0045504)
1.1 9.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 9.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 8.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 7.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 7.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 6.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 5.9 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 5.9 GO:0008017 microtubule binding(GO:0008017)
0.2 5.3 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 5.3 GO:0070840 dynein complex binding(GO:0070840)
0.2 5.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.3 5.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 5.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.7 4.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 4.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 4.1 GO:0070700 BMP receptor binding(GO:0070700)
0.2 4.0 GO:0001222 transcription corepressor binding(GO:0001222)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 7.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 6.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 6.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 5.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 4.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 3.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.1 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 1.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 PID_ATM_PATHWAY ATM pathway
0.0 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 8.3 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 6.7 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 5.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 4.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 3.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 3.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 3.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.0 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.1 3.0 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 2.9 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 2.8 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 2.7 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.9 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)