Motif ID: OLIG1
Z-value: 0.499
Transcription factors associated with OLIG1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| OLIG1 | ENSG00000184221.8 | OLIG1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OLIG1 | hg19_v2_chr21_+_34442439_34442455 | 0.44 | 3.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.1 | 0.6 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.1 | 0.4 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.1 | 2.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 0.7 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.1 | 0.6 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 1.1 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.1 | 0.4 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 0.3 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.1 | 0.4 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.1 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 0.3 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.1 | 0.9 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.4 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 0.3 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.0 | 0.3 | GO:1903895 | negative regulation of IRE1-mediated unfolded protein response(GO:1903895) |
| 0.0 | 0.2 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.0 | 0.3 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.0 | 0.2 | GO:0030805 | regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
| 0.0 | 0.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.0 | 1.0 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.0 | 0.2 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 0.0 | 0.3 | GO:0051660 | cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.3 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.1 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.2 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.0 | 0.1 | GO:0033512 | L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) |
| 0.0 | 0.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.2 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.0 | 0.1 | GO:0009436 | glyoxylate catabolic process(GO:0009436) |
| 0.0 | 0.1 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.0 | 0.1 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.0 | 0.1 | GO:0090345 | alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.0 | 0.2 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.8 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 0.3 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.1 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.0 | 0.1 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 0.0 | 0.1 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.4 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.1 | GO:2000546 | positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.0 | 0.1 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.2 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) |
| 0.0 | 0.0 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
| 0.0 | 0.1 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
| 0.0 | 0.6 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.0 | 0.0 | GO:1990918 | double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.0 | 0.2 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.1 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.0 | 0.1 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.1 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.0 | 0.1 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.0 | 0.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.1 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.0 | 0.4 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.7 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.1 | 0.2 | GO:0036025 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.1 | 0.6 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.8 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.0 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.0 | 0.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059) |
| 0.0 | 0.3 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 0.1 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.2 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 0.1 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.6 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.0 | 0.9 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 0.7 | GO:0001533 | cornified envelope(GO:0001533) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.1 | 0.3 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 0.1 | 0.2 | GO:0052593 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.1 | 0.2 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.1 | 0.3 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.1 | 0.2 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.0 | 0.6 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.0 | 1.0 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.3 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 0.5 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.1 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.0 | 0.5 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.0 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 1.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.1 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.0 | 0.4 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.2 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.0 | 0.1 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 0.3 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.3 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.1 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.0 | 0.1 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 0.1 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.0 | 0.1 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.1 | GO:0008453 | alanine-glyoxylate transaminase activity(GO:0008453) |
| 0.0 | 0.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.0 | 0.9 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.2 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 0.1 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 0.1 | GO:0030884 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.0 | 3.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.0 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.0 | 0.3 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.1 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.0 | 0.3 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.1 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.3 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 1.1 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.0 | 0.8 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.3 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.8 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 0.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.0 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 1.3 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.7 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.3 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.1 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
