Motif ID: OLIG2_NEUROD1_ATOH1
Z-value: 0.851
Transcription factors associated with OLIG2_NEUROD1_ATOH1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ATOH1 | ENSG00000172238.3 | ATOH1 |
| NEUROD1 | ENSG00000162992.3 | NEUROD1 |
| OLIG2 | ENSG00000205927.4 | OLIG2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NEUROD1 | hg19_v2_chr2_-_182545603_182545603 | 0.41 | 4.7e-02 | Click! |
| ATOH1 | hg19_v2_chr4_+_94750014_94750042 | -0.17 | 4.2e-01 | Click! |
| OLIG2 | hg19_v2_chr21_+_34398153_34398250 | -0.03 | 8.8e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 208 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 4.3 | GO:0031424 | keratinization(GO:0031424) |
| 0.8 | 3.3 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.0 | 3.2 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 2.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.3 | 2.3 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.2 | 2.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.2 | 2.0 | GO:0046886 | positive regulation of hormone biosynthetic process(GO:0046886) |
| 0.2 | 1.9 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.1 | 1.9 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 1.8 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.2 | 1.7 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 1.7 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.5 | 1.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.0 | 1.6 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.0 | 1.5 | GO:0097435 | fibril organization(GO:0097435) |
| 0.0 | 1.5 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.4 | 1.4 | GO:0036378 | calcitriol biosynthetic process from calciol(GO:0036378) |
| 0.1 | 1.4 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 1.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 74 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 4.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 3.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 3.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 2.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 2.1 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 1.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 1.6 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.4 | 1.3 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 1.3 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.2 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 1.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 125 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 3.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.3 | 2.2 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.0 | 2.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.5 | 2.0 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.0 | 1.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 1.8 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 1.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.7 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 1.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.4 | 1.4 | GO:0070643 | vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643) |
| 0.0 | 1.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 1.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 1.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 1.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 1.2 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.2 | 1.2 | GO:0042015 | interleukin-20 binding(GO:0042015) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.6 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 2.2 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.0 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.5 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.5 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.1 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 1.1 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 1.1 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 1.1 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 0.9 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.6 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 42 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 3.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.5 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 2.0 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 1.9 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 1.8 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.6 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.4 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.4 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.2 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 1.2 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.0 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.0 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.9 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.8 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.8 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
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