Motif ID: OLIG3_NEUROD2_NEUROG2
Z-value: 0.830
Transcription factors associated with OLIG3_NEUROD2_NEUROG2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NEUROD2 | ENSG00000171532.4 | NEUROD2 |
| NEUROG2 | ENSG00000178403.3 | NEUROG2 |
| OLIG3 | ENSG00000177468.5 | OLIG3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OLIG3 | hg19_v2_chr6_-_137815524_137815537 | -0.17 | 4.2e-01 | Click! |
| NEUROG2 | hg19_v2_chr4_-_113437328_113437337 | -0.16 | 4.6e-01 | Click! |
| NEUROD2 | hg19_v2_chr17_-_37764128_37764258 | 0.05 | 8.3e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 152 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 2.5 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 2.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 2.4 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.5 | 2.2 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.0 | 1.7 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.1 | 1.4 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.3 | 1.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.0 | 1.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 1.0 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.1 | 1.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.0 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.1 | 0.8 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 0.8 | GO:0042269 | regulation of natural killer cell mediated cytotoxicity(GO:0042269) |
| 0.2 | 0.7 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.0 | 0.7 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.2 | 0.6 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 0.2 | 0.6 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 0.6 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 40 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 2.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 2.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 1.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.0 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.2 | 0.7 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.1 | 0.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.6 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.1 | 0.5 | GO:0031166 | integral component of vacuolar membrane(GO:0031166) |
| 0.0 | 0.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.4 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.0 | 0.4 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.4 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.3 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 118 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 2.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 2.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 2.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.4 | 2.2 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.1 | 1.3 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 1.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.3 | 1.0 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.1 | 1.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 1.0 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 0.9 | GO:0022884 | macromolecule transmembrane transporter activity(GO:0022884) |
| 0.2 | 0.7 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.7 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 0.7 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.7 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.6 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 0.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 0.5 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.1 | 0.5 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.2 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.8 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.8 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.7 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.6 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.2 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 0.1 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.1 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 25 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.6 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.3 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 0.8 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.7 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.7 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.7 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 0.5 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.5 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.4 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 0.4 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.4 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.4 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.3 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.3 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
|
|
|