Motif ID: ONECUT2_ONECUT3
Z-value: 0.787
Transcription factors associated with ONECUT2_ONECUT3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ONECUT2 | ENSG00000119547.5 | ONECUT2 |
| ONECUT3 | ENSG00000205922.4 | ONECUT3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT3 | hg19_v2_chr19_+_1752372_1752372 | 0.70 | 1.4e-04 | Click! |
| ONECUT2 | hg19_v2_chr18_+_55102917_55102985 | 0.35 | 9.7e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 73 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.0 | 2.7 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.1 | 1.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 1.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 1.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) microvillus assembly(GO:0030033) |
| 0.0 | 1.6 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 0.0 | 1.2 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.0 | 1.2 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.1 | 1.1 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 1.1 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 1.1 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
| 0.3 | 1.0 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.0 | 1.0 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 1.0 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.9 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 0.8 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.2 | 0.7 | GO:1903487 | regulation of lactation(GO:1903487) |
| 0.2 | 0.7 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 0.1 | 0.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 0.7 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 22 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 1.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 1.2 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 0.9 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.5 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.5 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.4 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 0.4 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.4 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 0.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
| 0.0 | 0.2 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 39 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 1.6 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 1.6 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 1.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.0 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 1.0 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.7 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.7 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.1 | 0.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.6 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 0.6 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 0.6 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 0.5 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
Gene overrepresentation in C2:CP category:
Showing 1 to 14 of 14 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.9 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.7 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 1.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.7 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.7 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.6 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.3 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 19 of 19 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 2.6 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.6 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.1 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.0 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 1.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.7 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.4 | REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.3 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.2 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.2 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.0 | 0.2 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
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