Motif ID: OSR1_OSR2

Z-value: 0.430

Transcription factors associated with OSR1_OSR2:

Gene SymbolEntrez IDGene Name
OSR1 ENSG00000143867.5 OSR1
OSR2 ENSG00000164920.5 OSR2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
OSR2hg19_v2_chr8_+_99956759_99956887-0.331.2e-01Click!
OSR1hg19_v2_chr2_-_19558373_19558414-0.135.4e-01Click!


Activity profile for motif OSR1_OSR2.

activity profile for motif OSR1_OSR2


Sorted Z-values histogram for motif OSR1_OSR2

Sorted Z-values for motif OSR1_OSR2



Network of associatons between targets according to the STRING database.



First level regulatory network of OSR1_OSR2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_169013666 0.990 ENST00000359299.3
 ANXA10
annexin A10
chr15_-_80263506 0.646 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr12_-_50419177 0.555 ENST00000454520.2
ENST00000546595.1
ENST00000548824.1
ENST00000549777.1
ENST00000546723.1
ENST00000427314.2
ENST00000552157.1
ENST00000552310.1
ENST00000548644.1
ENST00000312377.5
ENST00000546786.1
ENST00000550149.1
ENST00000546764.1
ENST00000552004.1
ENST00000548320.1
ENST00000547905.1
ENST00000550651.1
ENST00000551145.1
ENST00000434422.1
ENST00000552921.1
 RACGAP1



















Rac GTPase activating protein 1



















chr5_+_68463043 0.554 ENST00000508407.1
ENST00000505500.1
 CCNB1

cyclin B1

chr7_+_76090993 0.529 ENST00000425780.1
ENST00000456590.1
ENST00000451769.1
ENST00000324432.5
ENST00000307569.8
ENST00000457529.1
ENST00000446600.1
ENST00000413936.2
ENST00000423646.1
ENST00000438930.1
ENST00000430490.2
 DTX2










deltex homolog 2 (Drosophila)










chr7_+_134212312 0.491 ENST00000359579.4
 AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr5_+_68462944 0.455 ENST00000506572.1
 CCNB1
cyclin B1
chr5_+_68462837 0.428 ENST00000256442.5
 CCNB1
cyclin B1
chr7_-_43769066 0.289 ENST00000223336.6
ENST00000310564.6
ENST00000431651.1
ENST00000415798.1
 COA1



cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)



chr22_+_31489344 0.289 ENST00000404574.1
 SMTN
smoothelin
chr7_-_43769051 0.285 ENST00000395880.3
 COA1
cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
chr9_+_36572851 0.278 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
 MELK







maternal embryonic leucine zipper kinase







chr3_+_149191723 0.272 ENST00000305354.4
 TM4SF4
transmembrane 4 L six family member 4
chr12_-_10251603 0.265 ENST00000457018.2
 CLEC1A
C-type lectin domain family 1, member A
chr3_-_50360192 0.263 ENST00000442581.1
ENST00000447092.1
ENST00000357750.4
 HYAL2


hyaluronoglucosaminidase 2


chr12_-_10251576 0.247 ENST00000315330.4
 CLEC1A
C-type lectin domain family 1, member A
chr16_+_23690138 0.232 ENST00000300093.4
 PLK1
polo-like kinase 1
chr10_+_78078088 0.225 ENST00000496424.2
 C10orf11
chromosome 10 open reading frame 11
chr15_+_63188009 0.219 ENST00000557900.1
 RP11-1069G10.2
RP11-1069G10.2
chr1_+_218458625 0.211 ENST00000366932.3
 RRP15
ribosomal RNA processing 15 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.1 0.6 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.5 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 0.3 GO:0019087 transformation of host cell by virus(GO:0019087)
0.1 0.3 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.3 GO:0070269 pyroptosis(GO:0070269)
0.1 0.2 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.0 0.2 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.1 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.6 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.0 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.5 GO:0047718 indanol dehydrogenase activity(GO:0047718)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.1 0.3 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition