Motif ID: OTX1

Z-value: 0.714


Transcription factors associated with OTX1:

Gene SymbolEntrez IDGene Name
OTX1 ENSG00000115507.5 OTX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
OTX1hg19_v2_chr2_+_63277927_632779380.573.3e-03Click!


Activity profile for motif OTX1.

activity profile for motif OTX1


Sorted Z-values histogram for motif OTX1

Sorted Z-values for motif OTX1



Network of associatons between targets according to the STRING database.



First level regulatory network of OTX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_65769392 3.511 ENST00000555736.1
CTD-2509G16.5
CTD-2509G16.5
chr19_-_55677999 3.118 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
DNAAF3


dynein, axonemal, assembly factor 3


chr19_-_55677920 3.022 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
DNAAF3


dynein, axonemal, assembly factor 3


chr17_-_4689649 2.479 ENST00000441199.2
ENST00000416307.2
VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr12_-_71533055 2.340 ENST00000552128.1
TSPAN8
tetraspanin 8
chr2_-_160654745 1.949 ENST00000259053.4
ENST00000429078.2
CD302

CD302 molecule

chr12_+_20963647 1.753 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr1_-_146696901 1.729 ENST00000369272.3
ENST00000441068.2
FMO5

flavin containing monooxygenase 5

chr12_+_20963632 1.713 ENST00000540853.1
ENST00000261196.2
SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr2_+_102721023 1.521 ENST00000409589.1
ENST00000409329.1
IL1R1

interleukin 1 receptor, type I

chr9_-_35563896 1.456 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr3_+_58223228 1.382 ENST00000478253.1
ENST00000295962.4
ABHD6

abhydrolase domain containing 6

chr17_-_34329084 1.270 ENST00000536149.1
ENST00000354059.4
CCL14
CCL15
chemokine (C-C motif) ligand 14
chemokine (C-C motif) ligand 15
chr10_+_114133773 1.232 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_111393659 1.227 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_104211294 1.159 ENST00000239125.1
C10orf95
chromosome 10 open reading frame 95
chr17_+_41158742 1.141 ENST00000415816.2
ENST00000438323.2
IFI35

interferon-induced protein 35

chr3_+_42544084 1.108 ENST00000543411.1
ENST00000438259.2
ENST00000439731.1
ENST00000325123.4
VIPR1



vasoactive intestinal peptide receptor 1



chr8_-_133637624 1.105 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr20_+_48884002 1.077 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3

RP11-290F20.3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 GO:0044458 motile cilium assembly(GO:0044458)
0.1 3.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 2.3 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.5 1.5 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 1.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 1.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 1.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 1.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.1 0.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.7 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.6 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.2 0.5 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.5 GO:0032466 negative regulation of cytokinesis(GO:0032466)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0005902 microvillus(GO:0005902)
0.0 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 1.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.0 GO:0034464 BBSome(GO:0034464)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.6 GO:1902911 protein kinase complex(GO:1902911)
0.0 0.6 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 0.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.0 0.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 1.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 1.5 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 1.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 1.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 1.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 1.0 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.3 ST_ADRENERGIC Adrenergic Pathway
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.1 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma