Motif ID: OTX2_CRX
Z-value: 0.637
Transcription factors associated with OTX2_CRX:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
CRX | ENSG00000105392.11 | CRX |
OTX2 | ENSG00000165588.12 | OTX2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
OTX2 | hg19_v2_chr14_-_57277178_57277203 | 0.68 | 2.3e-04 | Click! |
CRX | hg19_v2_chr19_+_48325097_48325211 | 0.46 | 2.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0097254 | renal tubular secretion(GO:0097254) |
0.4 | 1.8 | GO:0061143 | alveolar primary septum development(GO:0061143) |
0.2 | 0.7 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
0.2 | 1.2 | GO:0060005 | vestibular reflex(GO:0060005) |
0.2 | 1.8 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
0.1 | 1.3 | GO:0072025 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) |
0.1 | 0.5 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.1 | 0.6 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
0.1 | 0.3 | GO:0014034 | neural crest cell fate commitment(GO:0014034) |
0.1 | 0.9 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
0.1 | 1.1 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
0.1 | 12.9 | GO:0070268 | cornification(GO:0070268) |
0.1 | 0.4 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.1 | 1.1 | GO:0043249 | erythrocyte maturation(GO:0043249) |
0.1 | 1.9 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
0.1 | 0.3 | GO:0007509 | mesoderm migration involved in gastrulation(GO:0007509) |
0.1 | 0.5 | GO:0046532 | regulation of photoreceptor cell differentiation(GO:0046532) |
0.1 | 0.4 | GO:1902162 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
0.1 | 0.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.1 | 0.7 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
0.1 | 0.3 | GO:1990637 | response to prolactin(GO:1990637) |
0.1 | 1.2 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) angiotensin-activated signaling pathway(GO:0038166) |
0.1 | 0.6 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
0.1 | 0.4 | GO:0051012 | microtubule sliding(GO:0051012) |
0.1 | 0.4 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
0.1 | 0.3 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
0.1 | 0.4 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
0.1 | 0.1 | GO:1903625 | negative regulation of DNA catabolic process(GO:1903625) |
0.1 | 1.1 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.1 | 0.6 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
0.1 | 0.5 | GO:0021564 | vagus nerve development(GO:0021564) |
0.1 | 0.3 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
0.1 | 0.4 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
0.1 | 0.9 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
0.1 | 0.3 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
0.1 | 0.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
0.1 | 0.7 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
0.1 | 0.2 | GO:0061743 | motor learning(GO:0061743) |
0.0 | 0.4 | GO:0016199 | axon midline choice point recognition(GO:0016199) |
0.0 | 0.3 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.0 | 0.3 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
0.0 | 0.2 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
0.0 | 0.2 | GO:0036269 | swimming behavior(GO:0036269) |
0.0 | 0.1 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
0.0 | 0.7 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
0.0 | 0.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.0 | 0.1 | GO:0009405 | pathogenesis(GO:0009405) |
0.0 | 0.2 | GO:2000334 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
0.0 | 0.1 | GO:0007231 | osmosensory signaling pathway(GO:0007231) |
0.0 | 0.3 | GO:0097475 | motor neuron migration(GO:0097475) |
0.0 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.0 | 0.2 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
0.0 | 1.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.0 | 1.4 | GO:0007340 | acrosome reaction(GO:0007340) |
0.0 | 1.5 | GO:0043486 | histone exchange(GO:0043486) |
0.0 | 0.1 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
0.0 | 0.4 | GO:0044351 | macropinocytosis(GO:0044351) |
0.0 | 0.2 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.0 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.0 | 0.1 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
0.0 | 0.1 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
0.0 | 0.1 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
0.0 | 0.2 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
0.0 | 0.5 | GO:0097320 | membrane tubulation(GO:0097320) |
0.0 | 0.1 | GO:0002326 | B cell lineage commitment(GO:0002326) |
0.0 | 0.2 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.0 | 0.5 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
0.0 | 0.4 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
0.0 | 0.1 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
0.0 | 0.1 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
0.0 | 0.7 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
0.0 | 0.3 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.0 | 0.1 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.0 | 0.1 | GO:0045726 | positive regulation of integrin biosynthetic process(GO:0045726) |
0.0 | 0.1 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
0.0 | 0.3 | GO:0051014 | actin filament severing(GO:0051014) |
0.0 | 0.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
0.0 | 0.1 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
0.0 | 0.2 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
0.0 | 0.8 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
0.0 | 0.1 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
0.0 | 0.0 | GO:1902227 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
0.0 | 0.9 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
0.0 | 0.1 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
0.0 | 0.4 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
0.0 | 0.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:1990667 | PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667) |
0.1 | 1.2 | GO:0032426 | stereocilium tip(GO:0032426) |
0.1 | 0.3 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
0.1 | 1.5 | GO:0000812 | Swr1 complex(GO:0000812) |
0.1 | 1.7 | GO:0030057 | desmosome(GO:0030057) |
0.1 | 0.2 | GO:0035841 | new growing cell tip(GO:0035841) |
0.1 | 0.4 | GO:0033165 | interphotoreceptor matrix(GO:0033165) |
0.1 | 3.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
0.0 | 8.5 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 0.6 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 0.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
0.0 | 0.2 | GO:0089701 | U2AF(GO:0089701) |
0.0 | 0.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.0 | 0.3 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.0 | 0.2 | GO:0070695 | FHF complex(GO:0070695) |
0.0 | 0.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
0.0 | 0.1 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
0.0 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.6 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
0.0 | 0.2 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
0.0 | 0.9 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.6 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
0.0 | 0.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.0 | 0.3 | GO:0032059 | bleb(GO:0032059) |
0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.1 | GO:0032444 | activin responsive factor complex(GO:0032444) |
0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0002046 | opsin binding(GO:0002046) |
0.2 | 1.1 | GO:0005499 | vitamin D binding(GO:0005499) |
0.2 | 0.7 | GO:0034189 | very-low-density lipoprotein particle binding(GO:0034189) |
0.2 | 1.8 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
0.2 | 0.7 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
0.1 | 0.6 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
0.1 | 0.9 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
0.1 | 0.3 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
0.1 | 1.5 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.1 | 0.3 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
0.1 | 0.5 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.1 | 1.2 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
0.1 | 0.3 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
0.1 | 1.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 0.2 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.1 | 0.3 | GO:0042835 | BRE binding(GO:0042835) |
0.1 | 0.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.0 | 1.8 | GO:0051183 | vitamin transporter activity(GO:0051183) |
0.0 | 0.2 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.0 | 0.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.0 | 0.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.0 | 1.0 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
0.0 | 0.2 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.0 | 0.1 | GO:0030366 | molybdopterin synthase activity(GO:0030366) |
0.0 | 1.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.2 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
0.0 | 0.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.0 | 0.4 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.0 | 0.3 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.0 | 0.2 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
0.0 | 1.5 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
0.0 | 0.4 | GO:0016918 | retinal binding(GO:0016918) |
0.0 | 0.3 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
0.0 | 0.1 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.0 | 0.3 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 5.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 0.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
0.0 | 0.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.0 | 0.4 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.0 | 0.3 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.0 | 0.2 | GO:0019966 | interleukin-1 binding(GO:0019966) |
0.0 | 0.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-C chemokine binding(GO:0019957) |
0.0 | 0.1 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.0 | 0.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.1 | GO:0051373 | FATZ binding(GO:0051373) |
0.0 | 0.2 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.0 | 0.8 | GO:0030145 | manganese ion binding(GO:0030145) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.3 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.1 | 1.5 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
0.0 | 2.7 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
0.0 | 1.4 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.0 | 0.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.0 | 1.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 0.3 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
0.0 | 0.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.0 | 0.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.7 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.5 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
0.0 | 3.3 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
0.0 | 1.2 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.0 | 0.9 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.1 | REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION | Genes involved in Binding and entry of HIV virion |
0.0 | 0.3 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
0.0 | 0.9 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.4 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
0.0 | 0.3 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 0.4 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
0.0 | 0.4 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 0.3 | REACTOME_OPSINS | Genes involved in Opsins |
0.0 | 0.4 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 0.4 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
0.0 | 0.4 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.0 | 0.3 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |