Motif ID: OTX2_CRX

Z-value: 0.637

Transcription factors associated with OTX2_CRX:

Gene SymbolEntrez IDGene Name
CRX ENSG00000105392.11 CRX
OTX2 ENSG00000165588.12 OTX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
OTX2hg19_v2_chr14_-_57277178_572772030.682.3e-04Click!
CRXhg19_v2_chr19_+_48325097_483252110.462.4e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of OTX2_CRX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_38859996 7.290 ENST00000264651.2
KRT24
keratin 24
chr8_+_54764346 2.705 ENST00000297313.3
ENST00000344277.6
RGS20

regulator of G-protein signaling 20

chr19_-_51538118 1.937 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr19_-_51538148 1.929 ENST00000319590.4
ENST00000250351.4
KLK12

kallikrein-related peptidase 12

chr15_-_74495188 1.762 ENST00000563965.1
ENST00000395105.4
STRA6

stimulated by retinoic acid 6

chrX_+_69488174 1.318 ENST00000480877.2
ENST00000307959.8
ARR3

arrestin 3, retinal (X-arrestin)

chr3_-_149095652 1.284 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr9_+_75229616 1.224 ENST00000340019.3
TMC1
transmembrane channel-like 1
chr5_-_149669192 1.190 ENST00000398376.3
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr9_+_116298778 1.158 ENST00000462143.1
RGS3
regulator of G-protein signaling 3
chr2_+_219472488 1.132 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chr8_-_91095099 1.130 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr16_+_58010339 1.100 ENST00000290871.5
ENST00000441824.2
TEPP

testis, prostate and placenta expressed

chr6_+_130339710 1.075 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr1_+_180897269 1.070 ENST00000367587.1
KIAA1614
KIAA1614
chr18_-_28681950 1.023 ENST00000251081.6
DSC2
desmocollin 2
chrX_+_69488155 0.920 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr11_-_62752162 0.909 ENST00000458333.2
ENST00000421062.2
SLC22A6

solute carrier family 22 (organic anion transporter), member 6

chrX_+_69509927 0.897 ENST00000374403.3
KIF4A
kinesin family member 4A
chr18_-_64271316 0.775 ENST00000540086.1
ENST00000580157.1
CDH19

cadherin 19, type 2

chr19_+_46001697 0.772 ENST00000451287.2
ENST00000324688.4
PPM1N

protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)

chr6_-_35480640 0.730 ENST00000428978.1
ENST00000322263.4
TULP1

tubby like protein 1

chr18_-_28682374 0.725 ENST00000280904.6
DSC2
desmocollin 2
chr15_+_33603147 0.689 ENST00000415757.3
ENST00000389232.4
RYR3

ryanodine receptor 3

chr1_+_11751748 0.667 ENST00000294485.5
DRAXIN
dorsal inhibitory axon guidance protein
chr1_+_55505184 0.650 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_-_150208320 0.617 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr15_-_34610962 0.603 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr16_-_58004992 0.594 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1


cyclic nucleotide gated channel beta 1


chr9_-_39288092 0.593 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3



contactin associated protein-like 3



chr12_+_7941989 0.592 ENST00000229307.4
NANOG
Nanog homeobox
chr10_-_105845674 0.587 ENST00000353479.5
ENST00000369733.3
COL17A1

collagen, type XVII, alpha 1

chr3_+_111393501 0.578 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr12_+_53693466 0.574 ENST00000267103.5
ENST00000548632.1
C12orf10

chromosome 12 open reading frame 10

chr3_-_54962100 0.562 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chrX_+_135279179 0.550 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr12_-_53189892 0.544 ENST00000309505.3
ENST00000417996.2
KRT3

keratin 3

chr19_-_51537982 0.538 ENST00000525263.1
KLK12
kallikrein-related peptidase 12
chr12_-_2027639 0.535 ENST00000586184.1
ENST00000587995.1
ENST00000585732.1
CACNA2D4


calcium channel, voltage-dependent, alpha 2/delta subunit 4


chr8_+_70378852 0.516 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1


sulfatase 1


chr19_+_48325097 0.507 ENST00000221996.7
ENST00000539067.1
CRX

cone-rod homeobox

chr6_+_35310312 0.506 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD



peroxisome proliferator-activated receptor delta



chr12_+_53693812 0.503 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr12_-_53171128 0.498 ENST00000332411.2
KRT76
keratin 76
chr6_+_34433844 0.487 ENST00000244458.2
ENST00000374043.2
PACSIN1

protein kinase C and casein kinase substrate in neurons 1

chr6_+_35310391 0.469 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD


peroxisome proliferator-activated receptor delta


chrX_+_41306575 0.464 ENST00000342595.2
ENST00000378220.1
NYX

nyctalopin

chr11_+_20044096 0.460 ENST00000533917.1
NAV2
neuron navigator 2
chrX_+_135278908 0.449 ENST00000539015.1
ENST00000370683.1
FHL1

four and a half LIM domains 1

chr20_+_42984330 0.449 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A



hepatocyte nuclear factor 4, alpha



chrX_-_124097620 0.441 ENST00000371130.3
ENST00000422452.2
TENM1

teneurin transmembrane protein 1

chr17_-_43209862 0.430 ENST00000322765.5
PLCD3
phospholipase C, delta 3
chr1_-_231560790 0.427 ENST00000366641.3
EGLN1
egl-9 family hypoxia-inducible factor 1
chr11_+_124735282 0.425 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_62439037 0.421 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr17_-_60885659 0.409 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885700 0.405 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr3_-_47950745 0.394 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr7_+_93535817 0.394 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_159409512 0.385 ENST00000423932.3
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr3_-_48229846 0.384 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A


cell division cycle 25A


chr7_-_83824169 0.384 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr10_-_48390973 0.383 ENST00000224600.4
RBP3
retinol binding protein 3, interstitial
chr3_+_130650738 0.382 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr11_-_8680383 0.377 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr6_-_66417107 0.372 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS



eyes shut homolog (Drosophila)



chr13_-_36050819 0.368 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr5_-_95768973 0.367 ENST00000311106.3
PCSK1
proprotein convertase subtilisin/kexin type 1
chr3_+_50649302 0.365 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr12_-_54779511 0.359 ENST00000551109.1
ENST00000546970.1
ZNF385A

zinc finger protein 385A

chr9_+_18474204 0.354 ENST00000276935.6
ADAMTSL1
ADAMTS-like 1
chr6_-_30658745 0.349 ENST00000376420.5
ENST00000376421.5
NRM

nurim (nuclear envelope membrane protein)

chr11_-_111783595 0.349 ENST00000528628.1
CRYAB
crystallin, alpha B
chr14_-_95236551 0.346 ENST00000238558.3
GSC
goosecoid homeobox
chr5_-_41510656 0.335 ENST00000377801.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr9_+_34179003 0.331 ENST00000545103.1
ENST00000543944.1
ENST00000536252.1
ENST00000540348.1
ENST00000297661.4
ENST00000379186.4
UBAP1





ubiquitin associated protein 1





chr5_-_41510725 0.323 ENST00000328457.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr14_+_96722152 0.320 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr18_+_32290218 0.302 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA


dystrobrevin, alpha


chr11_-_62752455 0.298 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr11_+_72975524 0.295 ENST00000540342.1
ENST00000542092.1
P2RY6

pyrimidinergic receptor P2Y, G-protein coupled, 6

chr6_-_138893661 0.294 ENST00000427025.2
NHSL1
NHS-like 1
chr2_+_219472637 0.293 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr1_-_150208291 0.292 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_150208363 0.290 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr11_+_72975578 0.290 ENST00000393592.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr14_-_58894332 0.288 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr7_+_28452130 0.288 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr1_-_39395165 0.288 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr10_-_86001210 0.288 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr17_+_43318434 0.288 ENST00000587489.1
FMNL1
formin-like 1
chr11_+_72975559 0.287 ENST00000349767.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr5_+_145718587 0.286 ENST00000230732.4
POU4F3
POU class 4 homeobox 3
chr7_+_93535866 0.285 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1


chr15_+_93443419 0.281 ENST00000557381.1
ENST00000420239.2
CHD2

chromodomain helicase DNA binding protein 2

chr18_-_64271363 0.279 ENST00000262150.2
CDH19
cadherin 19, type 2
chr19_-_42931567 0.279 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr9_-_95244781 0.277 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN



asporin



chr18_+_616672 0.273 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr2_-_70780572 0.273 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr8_-_25281747 0.272 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr11_-_62752429 0.257 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr3_-_50649192 0.255 ENST00000443053.2
ENST00000348721.3
CISH

cytokine inducible SH2-containing protein

chr4_-_153601136 0.252 ENST00000504064.1
ENST00000304385.3
TMEM154

transmembrane protein 154

chr2_+_85822839 0.252 ENST00000441634.1
RNF181
ring finger protein 181
chr9_+_18474098 0.251 ENST00000327883.7
ENST00000431052.2
ENST00000380570.4
ADAMTSL1


ADAMTS-like 1


chr11_+_128563652 0.248 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr17_+_7905912 0.247 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr2_+_192141611 0.243 ENST00000392316.1
MYO1B
myosin IB
chr7_+_80231466 0.242 ENST00000309881.7
ENST00000534394.1
CD36

CD36 molecule (thrombospondin receptor)

chr6_-_88411911 0.241 ENST00000257787.5
AKIRIN2
akirin 2
chr17_-_71640227 0.235 ENST00000388726.3
ENST00000392650.3
SDK2

sidekick cell adhesion molecule 2

chr19_+_56166360 0.228 ENST00000308924.4
U2AF2
U2 small nuclear RNA auxiliary factor 2
chr9_-_131486367 0.226 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12




zinc finger, DHHC-type containing 12




chr18_+_616711 0.223 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr16_+_81272287 0.222 ENST00000425577.2
ENST00000564552.1
BCMO1

beta-carotene 15,15'-monooxygenase 1

chr19_-_48547294 0.221 ENST00000293255.2
CABP5
calcium binding protein 5
chr5_-_11589131 0.221 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr18_-_35145728 0.215 ENST00000361795.5
ENST00000603232.1
CELF4

CUGBP, Elav-like family member 4

chr11_-_75017734 0.213 ENST00000532525.1
ARRB1
arrestin, beta 1
chr18_-_70532906 0.208 ENST00000299430.2
ENST00000397929.1
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr9_+_103204553 0.207 ENST00000334943.6
ENST00000502978.1
TMEFF1
MSANTD3-TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
MSANTD3-TMEFF1 readthrough
chr2_+_120770581 0.206 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr1_+_153651078 0.202 ENST00000368680.3
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr8_-_80993010 0.200 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52




tumor protein D52




chr2_+_201170703 0.196 ENST00000358677.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chrX_+_28605516 0.192 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr5_-_11588907 0.191 ENST00000513598.1
ENST00000503622.1
CTNND2

catenin (cadherin-associated protein), delta 2

chr3_+_4535025 0.188 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1




inositol 1,4,5-trisphosphate receptor, type 1




chr2_-_89459813 0.186 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr6_+_31555045 0.184 ENST00000396101.3
ENST00000490742.1
LST1

leukocyte specific transcript 1

chr1_-_53608289 0.184 ENST00000371491.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr8_+_42873548 0.182 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr11_-_111794446 0.182 ENST00000527950.1
CRYAB
crystallin, alpha B
chrX_-_153363125 0.180 ENST00000407218.1
ENST00000453960.2
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr10_+_52751010 0.179 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chrX_+_79675965 0.178 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr17_-_39661849 0.176 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13



keratin 13



chr20_+_59654146 0.176 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr16_+_8715536 0.174 ENST00000563958.1
ENST00000381920.3
ENST00000564554.1
METTL22


methyltransferase like 22


chr1_-_150208412 0.173 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E



acidic (leucine-rich) nuclear phosphoprotein 32 family, member E



chr10_+_24528108 0.169 ENST00000438429.1
KIAA1217
KIAA1217
chr15_+_58430567 0.168 ENST00000536493.1
AQP9
aquaporin 9
chr10_-_76868931 0.167 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13




dual specificity phosphatase 13




chr18_-_21891460 0.166 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr10_+_102505468 0.165 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2



paired box 2



chr3_-_137851220 0.159 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr2_-_30144432 0.157 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr20_-_31124186 0.155 ENST00000375678.3
C20orf112
chromosome 20 open reading frame 112
chr21_-_35016231 0.152 ENST00000438788.1
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr2_-_119605253 0.151 ENST00000295206.6
EN1
engrailed homeobox 1
chr3_-_98241358 0.151 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1



claudin domain containing 1



chr15_+_58430368 0.150 ENST00000558772.1
ENST00000219919.4
AQP9

aquaporin 9

chr12_-_52604607 0.148 ENST00000551894.1
ENST00000553017.1
C12orf80

chromosome 12 open reading frame 80

chr12_+_81101277 0.148 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr2_+_201170596 0.147 ENST00000439084.1
ENST00000409718.1
SPATS2L

spermatogenesis associated, serine-rich 2-like

chr15_-_65407524 0.146 ENST00000559089.1
UBAP1L
ubiquitin associated protein 1-like
chr11_-_36619771 0.144 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2


recombination activating gene 2


chr7_-_128415844 0.143 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr1_-_11751665 0.142 ENST00000376667.3
ENST00000235310.3
MAD2L2

MAD2 mitotic arrest deficient-like 2 (yeast)

chr2_-_121223697 0.142 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr10_+_103986085 0.139 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr8_-_133123406 0.138 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr1_-_11751529 0.138 ENST00000376672.1
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr5_-_36301984 0.133 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L


RAN binding protein 3-like


chr12_-_14849470 0.132 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_-_136873735 0.132 ENST00000409817.1
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_+_81771806 0.132 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2





latrophilin 2





chr14_-_22005062 0.131 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr1_+_144989309 0.129 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr3_+_130279178 0.127 ENST00000358511.6
ENST00000453409.2
COL6A6

collagen, type VI, alpha 6

chr8_+_65492756 0.126 ENST00000321870.1
BHLHE22
basic helix-loop-helix family, member e22
chr13_-_33780133 0.124 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr15_-_31453157 0.123 ENST00000559177.1
ENST00000558445.1
TRPM1

transient receptor potential cation channel, subfamily M, member 1

chr20_-_49308048 0.123 ENST00000327979.2
FAM65C
family with sequence similarity 65, member C
chr1_+_18957500 0.121 ENST00000375375.3
PAX7
paired box 7
chr6_+_155537771 0.120 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr17_+_48911942 0.119 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr2_-_55237484 0.119 ENST00000394609.2
RTN4
reticulon 4
chr1_+_244816237 0.116 ENST00000302550.11
DESI2
desumoylating isopeptidase 2
chr6_-_30899924 0.115 ENST00000359086.3
SFTA2
surfactant associated 2
chr11_-_67290867 0.115 ENST00000353903.5
ENST00000294288.4
CABP2

calcium binding protein 2

chr2_+_115219171 0.113 ENST00000409163.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr10_+_95372289 0.113 ENST00000371447.3
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr9_+_18474163 0.112 ENST00000380566.4
ADAMTSL1
ADAMTS-like 1
chr1_-_150208498 0.112 ENST00000314136.8
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_173174681 0.111 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_+_39989580 0.109 ENST00000596614.1
ENST00000205143.4
DLL3

delta-like 3 (Drosophila)

chr19_+_39989535 0.108 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr3_-_170626418 0.107 ENST00000474096.1
ENST00000295822.2
EIF5A2

eukaryotic translation initiation factor 5A2

chr6_+_31554962 0.105 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1




leukocyte specific transcript 1




chr20_-_49307897 0.105 ENST00000535356.1
FAM65C
family with sequence similarity 65, member C
chr1_-_151965048 0.104 ENST00000368809.1
S100A10
S100 calcium binding protein A10
chr2_+_33661382 0.104 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_-_214016314 0.103 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chrX_-_54384425 0.103 ENST00000375169.3
ENST00000354646.2
WNK3

WNK lysine deficient protein kinase 3

chr1_-_102312517 0.103 ENST00000338858.5
OLFM3
olfactomedin 3
chr2_+_85822857 0.102 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
RNF181


ring finger protein 181


chr7_-_129592700 0.101 ENST00000472396.1
ENST00000355621.3
UBE2H

ubiquitin-conjugating enzyme E2H

chr12_-_110937351 0.101 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0097254 renal tubular secretion(GO:0097254)
0.4 1.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 0.7 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.2 1.2 GO:0060005 vestibular reflex(GO:0060005)
0.2 1.8 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 1.3 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.6 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.3 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 1.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.1 12.9 GO:0070268 cornification(GO:0070268)
0.1 0.4 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.5 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 0.4 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.7 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.3 GO:1990637 response to prolactin(GO:1990637)
0.1 1.2 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) angiotensin-activated signaling pathway(GO:0038166)
0.1 0.6 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.4 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.1 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.1 1.1 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.5 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.3 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.3 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 1.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.4 GO:0007340 acrosome reaction(GO:0007340)
0.0 1.5 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.4 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.2 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.1 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.0 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990667 PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 1.5 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.7 GO:0030057 desmosome(GO:0030057)
0.1 0.2 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.4 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 3.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 8.5 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0002046 opsin binding(GO:0002046)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.2 0.7 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.2 1.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2 0.7 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.9 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.3 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.3 GO:0042835 BRE binding(GO:0042835)
0.1 0.6 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 1.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 1.0 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 1.5 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.4 GO:0016918 retinal binding(GO:0016918)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 2.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.3 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 3.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.9 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_OPSINS Genes involved in Opsins
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions