Motif ID: PATZ1_KLF4

Z-value: 2.142

Transcription factors associated with PATZ1_KLF4:

Gene SymbolEntrez IDGene Name
KLF4 ENSG00000136826.10 KLF4
PATZ1 ENSG00000100105.13 PATZ1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PATZ1hg19_v2_chr22_-_31741757_31741770-0.779.1e-06Click!
KLF4hg19_v2_chr9_-_110251836_1102519270.321.3e-01Click!


Activity profile for motif PATZ1_KLF4.

activity profile for motif PATZ1_KLF4


Sorted Z-values histogram for motif PATZ1_KLF4

Sorted Z-values for motif PATZ1_KLF4



Network of associatons between targets according to the STRING database.



First level regulatory network of PATZ1_KLF4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_4135693 20.545 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
 ECI2


enoyl-CoA delta isomerase 2


chr6_-_4135825 19.825 ENST00000380118.3
ENST00000413766.2
ENST00000361538.2
 ECI2


enoyl-CoA delta isomerase 2


chr8_-_144651024 18.137 ENST00000524906.1
ENST00000532862.1
ENST00000534459.1
 MROH6


maestro heat-like repeat family member 6


chr19_-_15344243 13.127 ENST00000602233.1
 EPHX3
epoxide hydrolase 3
chr19_-_51472031 12.805 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_+_35645817 12.631 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr9_-_139891165 11.990 ENST00000494426.1
 CLIC3
chloride intracellular channel 3
chr1_+_65886244 11.669 ENST00000344610.8
 LEPR
leptin receptor
chr11_-_568369 11.626 ENST00000534540.1
ENST00000528245.1
ENST00000500447.1
ENST00000533920.1
 MIR210HG



MIR210 host gene (non-protein coding)



chr19_+_35645618 11.333 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr19_-_55658687 11.286 ENST00000593046.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr10_-_15210615 11.108 ENST00000378150.1
 NMT2
N-myristoyltransferase 2
chr1_-_9189229 11.058 ENST00000377411.4
 GPR157
G protein-coupled receptor 157
chr10_-_15210666 10.588 ENST00000378165.4
 NMT2
N-myristoyltransferase 2
chr8_+_86376081 10.579 ENST00000285379.5
 CA2
carbonic anhydrase II
chr19_-_51504852 10.422 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr19_-_51504411 10.144 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr19_-_51487071 10.007 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr22_+_38071615 9.857 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr19_-_51472222 9.841 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,633 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 43.2 GO:0031581 hemidesmosome assembly(GO:0031581)
7.0 41.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.6 41.7 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.4 37.6 GO:0070268 cornification(GO:0070268)
1.8 37.1 GO:0016540 protein autoprocessing(GO:0016540)
3.5 31.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.6 29.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.6 28.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.2 27.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
1.1 27.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
1.1 24.3 GO:0032060 bleb assembly(GO:0032060)
1.5 24.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.9 23.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
7.9 23.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.9 23.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.4 22.9 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.4 21.9 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
7.2 21.6 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.0 21.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
1.8 21.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 523 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 101.2 GO:0005730 nucleolus(GO:0005730)
0.2 59.2 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.5 53.0 GO:0032432 actin filament bundle(GO:0032432)
0.0 43.4 GO:0005615 extracellular space(GO:0005615)
0.3 42.1 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
6.0 41.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.6 39.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 39.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.5 36.2 GO:0005861 troponin complex(GO:0005861)
1.3 32.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
1.3 31.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.4 31.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.3 31.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 31.0 GO:0030027 lamellipodium(GO:0030027)
1.6 30.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 30.2 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.5 29.2 GO:0002102 podosome(GO:0002102)
0.2 28.8 GO:0005882 intermediate filament(GO:0005882)
0.3 27.2 GO:0005901 caveola(GO:0005901)
1.3 26.5 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 918 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 185.3 GO:0045296 cadherin binding(GO:0045296)
0.4 113.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 88.7 GO:0005096 GTPase activator activity(GO:0005096)
0.5 66.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 52.5 GO:0008017 microtubule binding(GO:0008017)
0.5 48.7 GO:0008307 structural constituent of muscle(GO:0008307)
9.9 39.7 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
2.8 39.5 GO:0031014 troponin T binding(GO:0031014)
0.3 32.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 29.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 29.3 GO:0051015 actin filament binding(GO:0051015)
0.7 29.2 GO:0043236 laminin binding(GO:0043236)
0.7 26.0 GO:0030506 ankyrin binding(GO:0030506)
0.6 26.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.7 23.9 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
7.2 21.6 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.8 21.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 20.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.4 20.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
1.3 19.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 114.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9 65.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 59.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.9 51.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.5 44.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 42.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 42.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 41.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
1.0 32.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.7 29.8 PID_IFNG_PATHWAY IFN-gamma pathway
0.6 29.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.5 26.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.4 26.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
1.3 25.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.6 23.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 23.1 PID_PLK1_PATHWAY PLK1 signaling events
0.5 22.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.9 21.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
1.4 19.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 19.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 80.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 45.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.9 42.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
1.1 40.1 REACTOME_KINESINS Genes involved in Kinesins
0.7 33.6 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
1.0 33.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
1.3 33.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 29.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 28.7 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.8 25.7 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.4 25.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.7 25.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.8 25.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
2.0 24.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.7 23.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 23.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
1.3 22.8 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.2 22.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 21.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.9 21.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE