Motif ID: PAX4

Z-value: 0.645


Transcription factors associated with PAX4:

Gene SymbolEntrez IDGene Name
PAX4 ENSG00000106331.10 PAX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX4hg19_v2_chr7_-_127255724_1272557800.135.5e-01Click!


Activity profile for motif PAX4.

activity profile for motif PAX4


Sorted Z-values histogram for motif PAX4

Sorted Z-values for motif PAX4



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_32407619 3.909 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr16_-_28621353 3.587 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr9_-_20622478 1.740 ENST00000355930.6
ENST00000380338.4
 MLLT3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr11_-_93276582 1.704 ENST00000298966.2
 SMCO4
single-pass membrane protein with coiled-coil domains 4
chr17_+_72270380 1.642 ENST00000582036.1
ENST00000307504.5
 DNAI2

dynein, axonemal, intermediate chain 2

chr4_+_39184024 1.618 ENST00000399820.3
ENST00000509560.1
ENST00000512112.1
ENST00000288634.7
ENST00000506503.1
 WDR19




WD repeat domain 19




chr4_+_165675269 1.613 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr4_-_84030996 1.564 ENST00000411416.2
 PLAC8
placenta-specific 8
chr6_-_130031358 1.400 ENST00000368149.2
 ARHGAP18
Rho GTPase activating protein 18
chr11_+_86085778 1.328 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
 CCDC81



coiled-coil domain containing 81



chr11_-_124622134 1.292 ENST00000326621.5
 VSIG2
V-set and immunoglobulin domain containing 2
chr19_+_14544099 1.197 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
 PKN1


protein kinase N1


chr16_-_28621312 1.190 ENST00000314752.7
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_62474803 1.184 ENST00000533982.1
ENST00000360796.5
 BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr11_-_124622083 1.152 ENST00000403470.1
 VSIG2
V-set and immunoglobulin domain containing 2
chr10_+_114135004 0.974 ENST00000393081.1
 ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_+_13134772 0.936 ENST00000587760.1
ENST00000585575.1
 NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr15_-_40401062 0.904 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
 BMF



Bcl2 modifying factor



chr6_+_32605195 0.900 ENST00000374949.2
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr18_-_53255766 0.893 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
 TCF4




transcription factor 4





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.1 GO:0006068 ethanol catabolic process(GO:0006068)
1.0 3.9 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 2.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 2.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 1.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 1.6 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 1.3 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 1.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.9 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.3 0.8 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185) positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.2 0.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 2.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.1 0.8 GO:0002177 manchette(GO:0002177)
0.1 0.8 GO:0097255 R2TP complex(GO:0097255)
0.1 0.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 0.5 GO:0032302 MutSbeta complex(GO:0032302)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.3 GO:1990742 microvesicle(GO:1990742)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0097386 glial cell projection(GO:0097386)
0.1 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.4 5.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 1.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.5 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.5 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.5 GO:0045503 dynein light chain binding(GO:0045503)
0.1 0.4 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters