Motif ID: PAX6

Z-value: 0.563


Transcription factors associated with PAX6:

Gene SymbolEntrez IDGene Name
PAX6 ENSG00000007372.16 PAX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX6hg19_v2_chr11_-_31839488_318395150.164.5e-01Click!


Activity profile for motif PAX6.

activity profile for motif PAX6


Sorted Z-values histogram for motif PAX6

Sorted Z-values for motif PAX6



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_2986107 1.016 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
 FOXM1


forkhead box M1


chr11_-_28129656 1.015 ENST00000263181.6
 KIF18A
kinesin family member 18A
chr11_-_58343319 1.014 ENST00000395074.2
 LPXN
leupaxin
chr7_-_97501706 1.013 ENST00000455086.1
ENST00000453600.1
 ASNS

asparagine synthetase (glutamine-hydrolyzing)

chr19_-_36019123 0.875 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
 SBSN


suprabasin


chr7_-_97501733 0.837 ENST00000444334.1
ENST00000422745.1
ENST00000394308.3
ENST00000451771.1
ENST00000175506.4
 ASNS




asparagine synthetase (glutamine-hydrolyzing)




chr11_-_87908600 0.797 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
 RAB38


RAB38, member RAS oncogene family


chr12_-_47473425 0.768 ENST00000550413.1
 AMIGO2
adhesion molecule with Ig-like domain 2
chr7_-_76255444 0.744 ENST00000454397.1
 POMZP3
POM121 and ZP3 fusion
chr1_+_163291732 0.707 ENST00000271452.3
 NUF2
NUF2, NDC80 kinetochore complex component
chr18_-_21242774 0.658 ENST00000322980.9
 ANKRD29
ankyrin repeat domain 29
chr6_-_131321863 0.622 ENST00000528282.1
 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_+_47473369 0.618 ENST00000546455.1
 PCED1B
PC-esterase domain containing 1B
chr12_-_47473707 0.569 ENST00000429635.1
 AMIGO2
adhesion molecule with Ig-like domain 2
chr13_+_96085847 0.549 ENST00000376873.3
 CLDN10
claudin 10
chr18_+_61420169 0.545 ENST00000425392.1
ENST00000336429.2
 SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr18_+_61445007 0.543 ENST00000447428.1
ENST00000546027.1
 SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr12_-_85306594 0.537 ENST00000266682.5
 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr21_+_39628852 0.522 ENST00000398938.2
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_131291572 0.508 ENST00000529208.1
 EPB41L2
erythrocyte membrane protein band 4.1-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.9 GO:0070981 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 1.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 1.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.0 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 1.0 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 1.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.9 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.8 GO:0015820 leucine transport(GO:0015820) proline transmembrane transport(GO:0035524)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.1 0.7 GO:0035803 egg coat formation(GO:0035803)
0.0 0.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 0.5 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.2 0.5 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.5 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0008091 spectrin(GO:0008091)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.3 0.9 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 0.8 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.7 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.4 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.9 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0042731 PH domain binding(GO:0042731)
0.0 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.8 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.2 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.8 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0032190 acrosin binding(GO:0032190)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.5 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 0.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.1 0.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis