Motif ID: PAX8

Z-value: 0.361


Transcription factors associated with PAX8:

Gene SymbolEntrez IDGene Name
PAX8 ENSG00000125618.12 PAX8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX8hg19_v2_chr2_-_113999260_1139992740.414.7e-02Click!


Activity profile for motif PAX8.

activity profile for motif PAX8


Sorted Z-values histogram for motif PAX8

Sorted Z-values for motif PAX8



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 0.701 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
KLK7


kallikrein-related peptidase 7


chr19_-_36019123 0.510 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN


suprabasin


chr4_+_75230853 0.497 ENST00000244869.2
EREG
epiregulin
chr1_-_153013588 0.442 ENST00000360379.3
SPRR2D
small proline-rich protein 2D
chr19_-_51537982 0.432 ENST00000525263.1
KLK12
kallikrein-related peptidase 12
chr6_+_31126291 0.423 ENST00000376257.3
ENST00000376255.4
TCF19

transcription factor 19

chr19_-_51538118 0.413 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr2_-_234763147 0.407 ENST00000411486.2
ENST00000432087.1
ENST00000441687.1
ENST00000414924.1
HJURP



Holliday junction recognition protein



chr19_-_51538148 0.402 ENST00000319590.4
ENST00000250351.4
KLK12

kallikrein-related peptidase 12

chr5_+_148521136 0.368 ENST00000506113.1
ABLIM3
actin binding LIM protein family, member 3
chr11_-_58343319 0.342 ENST00000395074.2
LPXN
leupaxin
chr17_-_39216344 0.337 ENST00000391418.2
KRTAP2-3
keratin associated protein 2-3
chr12_+_75874460 0.335 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr7_-_97501706 0.312 ENST00000455086.1
ENST00000453600.1
ASNS

asparagine synthetase (glutamine-hydrolyzing)

chr1_+_13359819 0.297 ENST00000376168.1
PRAMEF5
PRAME family member 5
chr22_-_37403839 0.291 ENST00000402860.3
ENST00000381821.1
TEX33

testis expressed 33

chr22_-_37403858 0.290 ENST00000405091.2
TEX33
testis expressed 33
chr10_+_135340859 0.282 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1


cytochrome P450, family 2, subfamily E, polypeptide 1


chr12_-_6961050 0.275 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr12_-_6960407 0.272 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
CDCA3



cell division cycle associated 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0070268 cornification(GO:0070268)
0.1 0.7 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 0.5 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.0 0.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.3 GO:0070981 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.1 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.3 GO:0010193 response to ozone(GO:0010193)
0.0 0.3 GO:0035803 egg coat formation(GO:0035803)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.3 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.0 0.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.2 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.2 GO:0048241 epinephrine transport(GO:0048241)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.1 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones