Motif ID: PBX1

Z-value: 0.748


Transcription factors associated with PBX1:

Gene SymbolEntrez IDGene Name
PBX1 ENSG00000185630.14 PBX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX1hg19_v2_chr1_+_164528866_1645288770.743.5e-05Click!


Activity profile for motif PBX1.

activity profile for motif PBX1


Sorted Z-values histogram for motif PBX1

Sorted Z-values for motif PBX1



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_63638339 3.169 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr1_+_104293028 2.031 ENST00000370079.3
 AMY1C
amylase, alpha 1C (salivary)
chr18_+_44526786 2.008 ENST00000245121.5
ENST00000356157.7
 KATNAL2

katanin p60 subunit A-like 2

chr1_+_104159999 1.934 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr9_+_140135665 1.774 ENST00000340384.4
 TUBB4B
tubulin, beta 4B class IVb
chr4_-_147867025 1.576 ENST00000502319.1
ENST00000325106.4
ENST00000504425.1
 TTC29


tetratricopeptide repeat domain 29


chr4_-_147866960 1.521 ENST00000513335.1
 TTC29
tetratricopeptide repeat domain 29
chr4_+_69962185 1.473 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_+_51549498 1.465 ENST00000358559.2
ENST00000298239.6
 MSMB

microseminoprotein, beta-

chr4_+_69962212 1.442 ENST00000508661.1
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr2_-_154335300 1.327 ENST00000325926.3
 RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chrX_+_125953746 1.260 ENST00000371125.3
 CXorf64
chromosome X open reading frame 64
chr20_+_52105495 1.234 ENST00000439873.2
 AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr4_+_69681710 1.190 ENST00000265403.7
ENST00000458688.2
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr11_+_71903169 1.122 ENST00000393676.3
 FOLR1
folate receptor 1 (adult)
chr8_+_99076750 1.107 ENST00000545282.1
 C8orf47
chromosome 8 open reading frame 47
chr11_-_34937858 1.002 ENST00000278359.5
 APIP
APAF1 interacting protein
chr8_+_99076509 0.967 ENST00000318528.3
 C8orf47
chromosome 8 open reading frame 47
chr5_+_140213815 0.955 ENST00000525929.1
ENST00000378125.3
 PCDHA7

protocadherin alpha 7

chr5_-_42825983 0.943 ENST00000506577.1
 SEPP1
selenoprotein P, plasma, 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.3 1.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.8 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.4 1.7 GO:0060830 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 1.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) pyroptosis(GO:0070269)
0.0 1.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.4 1.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.0 1.1 GO:0009988 cell-cell recognition(GO:0009988)
0.2 1.0 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.2 0.9 GO:0006740 NADPH regeneration(GO:0006740)
0.2 0.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.9 GO:0045176 apical protein localization(GO:0045176)
0.1 0.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 0.6 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.6 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.6 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.5 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1 0.5 GO:0071279 cellular response to cobalt ion(GO:0071279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.2 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0030914 STAGA complex(GO:0030914)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.4 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.4 GO:0097196 Shu complex(GO:0097196)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 2.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.5 1.9 GO:0016160 amylase activity(GO:0016160)
0.0 1.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 1.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 1.0 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 1.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 0.9 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.9 GO:0043495 protein anchor(GO:0043495)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.4 4.0 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.9 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation