Motif ID: PBX2

Z-value: 0.400


Transcription factors associated with PBX2:

Gene SymbolEntrez IDGene Name
PBX2 ENSG00000204304.7 PBX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.811.6e-06Click!


Activity profile for motif PBX2.

activity profile for motif PBX2


Sorted Z-values histogram for motif PBX2

Sorted Z-values for motif PBX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_55658252 1.419 ENST00000395425.2
 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_31440377 1.370 ENST00000444918.2
ENST00000403897.3
 CAPN14

calpain 14

chr14_-_55658323 1.360 ENST00000554067.1
ENST00000247191.2
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr2_+_234104079 1.114 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_-_190044480 1.004 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr12_-_28124903 0.990 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
 PTHLH


parathyroid hormone-like hormone


chr12_-_28125638 0.812 ENST00000545234.1
 PTHLH
parathyroid hormone-like hormone
chr15_+_67418047 0.600 ENST00000540846.2
 SMAD3
SMAD family member 3
chr11_-_2162162 0.492 ENST00000381389.1
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_-_100065419 0.488 ENST00000504125.1
ENST00000505590.1
 ADH4

alcohol dehydrogenase 4 (class II), pi polypeptide

chr7_+_134528635 0.424 ENST00000445569.2
 CALD1
caldesmon 1
chr11_+_69455855 0.385 ENST00000227507.2
ENST00000536559.1
 CCND1

cyclin D1

chr4_+_37962018 0.380 ENST00000504686.1
 PTTG2
pituitary tumor-transforming 2
chr2_+_234601512 0.364 ENST00000305139.6
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_204732666 0.344 ENST00000295854.6
ENST00000472206.1
 CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr11_+_62432777 0.316 ENST00000532971.1
 METTL12
methyltransferase like 12
chrX_+_46696372 0.308 ENST00000218340.3
 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_-_99917639 0.251 ENST00000308528.4
 LYG1
lysozyme G-like 1
chr17_-_29151794 0.244 ENST00000324238.6
 CRLF3
cytokine receptor-like factor 3
chr2_+_33661382 0.241 ENST00000402538.3
 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_101702417 0.232 ENST00000305352.6
 S1PR1
sphingosine-1-phosphate receptor 1
chr3_+_188889737 0.228 ENST00000345063.3
 TPRG1
tumor protein p63 regulated 1
chr9_-_128246769 0.221 ENST00000444226.1
 MAPKAP1
mitogen-activated protein kinase associated protein 1
chr5_+_54320078 0.213 ENST00000231009.2
 GZMK
granzyme K (granzyme 3; tryptase II)
chr1_+_207038699 0.195 ENST00000367098.1
 IL20
interleukin 20
chr2_+_204732487 0.195 ENST00000302823.3
 CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr2_+_20646824 0.184 ENST00000272233.4
 RHOB
ras homolog family member B
chr14_+_64854958 0.159 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
 MTHFD1



methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase



chrX_+_119737806 0.153 ENST00000371317.5
 MCTS1
malignant T cell amplified sequence 1
chr1_+_62417957 0.141 ENST00000307297.7
ENST00000543708.1
 INADL

InaD-like (Drosophila)

chr11_-_104769141 0.137 ENST00000508062.1
ENST00000422698.2
 CASP12

caspase 12 (gene/pseudogene)

chr14_+_27342334 0.125 ENST00000548170.1
ENST00000552926.1
 RP11-384J4.1

RP11-384J4.1

chr3_-_52864680 0.103 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
 ITIH4




inter-alpha-trypsin inhibitor heavy chain family, member 4




chr11_-_111794446 0.100 ENST00000527950.1
 CRYAB
crystallin, alpha B
chr3_+_159943362 0.100 ENST00000326474.3
 C3orf80
chromosome 3 open reading frame 80
chr10_-_45474237 0.096 ENST00000448778.1
ENST00000298295.3
 C10orf10

chromosome 10 open reading frame 10

chr4_-_100065440 0.089 ENST00000508393.1
ENST00000265512.7
 ADH4

alcohol dehydrogenase 4 (class II), pi polypeptide

chr10_+_124320195 0.084 ENST00000359586.6
 DMBT1
deleted in malignant brain tumors 1
chr14_-_23624511 0.080 ENST00000529705.2
 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr18_-_72920372 0.079 ENST00000581620.1
ENST00000582437.1
 ZADH2

zinc binding alcohol dehydrogenase domain containing 2

chr3_-_129158850 0.070 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
 MBD4



methyl-CpG binding domain protein 4



chr16_+_1128781 0.062 ENST00000293897.4
ENST00000562758.1
 SSTR5

somatostatin receptor 5

chr10_+_124320156 0.062 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
 DMBT1





deleted in malignant brain tumors 1





chr3_-_129158676 0.052 ENST00000393278.2
 MBD4
methyl-CpG binding domain protein 4
chr2_+_113033164 0.038 ENST00000409871.1
ENST00000343936.4
 ZC3H6

zinc finger CCCH-type containing 6

chr2_+_234602305 0.022 ENST00000406651.1
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_44396000 0.022 ENST00000409895.4
ENST00000409432.3
ENST00000282412.4
ENST00000378551.2
ENST00000345249.4
 PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr22_+_42017987 0.013 ENST00000405506.1
 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr2_+_27255806 0.002 ENST00000238788.9
ENST00000404032.3
 TMEM214

transmembrane protein 214

chr16_+_1832902 0.000 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
 NUBP2





nucleotide binding protein 2






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.4 1.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.2 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 1.8 GO:0002076 osteoblast development(GO:0002076)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.6 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.4 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.6 GO:0005503 all-trans retinal binding(GO:0005503)
0.1 0.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 1.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 2.8 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation