Motif ID: PBX2

Z-value: 0.400


Transcription factors associated with PBX2:

Gene SymbolEntrez IDGene Name
PBX2 ENSG00000204304.7 PBX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.811.6e-06Click!


Activity profile for motif PBX2.

activity profile for motif PBX2


Sorted Z-values histogram for motif PBX2

Sorted Z-values for motif PBX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 50 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_55658252 1.419 ENST00000395425.2
 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_31440377 1.370 ENST00000444918.2
ENST00000403897.3
 CAPN14

calpain 14

chr14_-_55658323 1.360 ENST00000554067.1
ENST00000247191.2
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr2_+_234104079 1.114 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_-_190044480 1.004 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr12_-_28124903 0.990 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
 PTHLH


parathyroid hormone-like hormone


chr12_-_28125638 0.812 ENST00000545234.1
 PTHLH
parathyroid hormone-like hormone
chr15_+_67418047 0.600 ENST00000540846.2
 SMAD3
SMAD family member 3
chr11_-_2162162 0.492 ENST00000381389.1
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_-_100065419 0.488 ENST00000504125.1
ENST00000505590.1
 ADH4

alcohol dehydrogenase 4 (class II), pi polypeptide

chr7_+_134528635 0.424 ENST00000445569.2
 CALD1
caldesmon 1
chr11_+_69455855 0.385 ENST00000227507.2
ENST00000536559.1
 CCND1

cyclin D1

chr4_+_37962018 0.380 ENST00000504686.1
 PTTG2
pituitary tumor-transforming 2
chr2_+_234601512 0.364 ENST00000305139.6
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_204732666 0.344 ENST00000295854.6
ENST00000472206.1
 CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr11_+_62432777 0.316 ENST00000532971.1
 METTL12
methyltransferase like 12
chrX_+_46696372 0.308 ENST00000218340.3
 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_-_99917639 0.251 ENST00000308528.4
 LYG1
lysozyme G-like 1
chr17_-_29151794 0.244 ENST00000324238.6
 CRLF3
cytokine receptor-like factor 3
chr2_+_33661382 0.241 ENST00000402538.3
 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.8 GO:0002076 osteoblast development(GO:0002076)
0.4 1.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.6 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.4 GO:0070141 response to UV-A(GO:0070141)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.2 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.1 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.6 GO:0005503 all-trans retinal binding(GO:0005503)
0.1 0.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation