Motif ID: PBX3

Z-value: 0.881


Transcription factors associated with PBX3:

Gene SymbolEntrez IDGene Name
PBX3 ENSG00000167081.12 PBX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX3hg19_v2_chr9_+_128509663_128509733-0.673.1e-04Click!


Activity profile for motif PBX3.

activity profile for motif PBX3


Sorted Z-values histogram for motif PBX3

Sorted Z-values for motif PBX3



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_65769392 4.302 ENST00000555736.1
 CTD-2509G16.5
CTD-2509G16.5
chr4_-_149363662 3.561 ENST00000355292.3
ENST00000358102.3
 NR3C2

nuclear receptor subfamily 3, group C, member 2

chr3_+_63638339 2.606 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr11_+_111385497 2.063 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
 C11orf88


chromosome 11 open reading frame 88


chr6_-_46138676 1.851 ENST00000371383.2
ENST00000230565.3
 ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chrX_-_8700171 1.837 ENST00000262648.3
 KAL1
Kallmann syndrome 1 sequence
chr19_-_55972936 1.573 ENST00000425675.2
ENST00000589080.1
ENST00000085068.3
 ISOC2


isochorismatase domain containing 2


chr16_+_30210552 1.529 ENST00000338971.5
 SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr1_+_85527987 1.506 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr4_-_23891693 1.433 ENST00000264867.2
 PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_116937636 1.315 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr6_-_119670919 1.304 ENST00000368468.3
 MAN1A1
mannosidase, alpha, class 1A, member 1
chr5_-_160279207 1.273 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr3_+_111393659 1.251 ENST00000477665.1
 PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr19_+_19976683 1.221 ENST00000592725.1
 ZNF253
zinc finger protein 253
chr19_-_23578220 1.218 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
 ZNF91



zinc finger protein 91



chr7_-_138386097 1.202 ENST00000421622.1
 SVOPL
SVOP-like
chr19_+_50180317 1.187 ENST00000534465.1
 PRMT1
protein arginine methyltransferase 1
chr19_-_12662314 1.176 ENST00000339282.7
ENST00000596193.1
 ZNF564

zinc finger protein 564

chr19_+_50706866 1.166 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
 MYH14




myosin, heavy chain 14, non-muscle





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 2.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.0 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 1.9 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.3 1.7 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.3 1.5 GO:0006740 NADPH regeneration(GO:0006740)
0.2 1.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.5 1.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.2 1.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.2 1.1 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.1 GO:0015074 DNA integration(GO:0015074)
0.1 1.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 1.0 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 1.0 GO:0015889 cobalamin transport(GO:0015889)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.7 GO:0034709 methylosome(GO:0034709)
0.0 1.6 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 1.5 GO:0030286 dynein complex(GO:0030286)
0.1 1.4 GO:0097440 apical dendrite(GO:0097440)
0.4 1.3 GO:0001534 radial spoke(GO:0001534)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.1 GO:0097255 R2TP complex(GO:0097255)
0.1 1.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:1990393 3M complex(GO:1990393)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 0.7 GO:0060187 cell pole(GO:0060187)
0.0 0.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.7 GO:0005657 replication fork(GO:0005657)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.8 2.5 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 2.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.7 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.5 1.5 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.3 1.5 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 1.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 1.2 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.2 1.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 1.0 GO:0047708 biotinidase activity(GO:0047708)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 4.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.0 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 1.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.3 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets