Motif ID: PDX1

Z-value: 0.553


Transcription factors associated with PDX1:

Gene SymbolEntrez IDGene Name
PDX1 ENSG00000139515.5 PDX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PDX1hg19_v2_chr13_+_28494130_284941680.331.1e-01Click!


Activity profile for motif PDX1.

activity profile for motif PDX1


Sorted Z-values histogram for motif PDX1

Sorted Z-values for motif PDX1



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152386732 1.032 ENST00000271835.3
 CRNN
cornulin
chr12_+_107712173 0.807 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr1_+_62439037 0.723 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr1_+_84609944 0.586 ENST00000370685.3
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr20_+_60174827 0.585 ENST00000543233.1
 CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr18_+_29027696 0.546 ENST00000257189.4
 DSG3
desmoglein 3
chr7_-_44229022 0.485 ENST00000403799.3
 GCK
glucokinase (hexokinase 4)
chr8_-_133123406 0.482 ENST00000434736.2
 HHLA1
HERV-H LTR-associating 1
chr4_-_139163491 0.476 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr15_+_75080883 0.468 ENST00000567571.1
 CSK
c-src tyrosine kinase
chr18_+_28898052 0.454 ENST00000257192.4
 DSG1
desmoglein 1
chr9_-_123639304 0.453 ENST00000436309.1
 PHF19
PHD finger protein 19
chr12_-_57328187 0.449 ENST00000293502.1
 SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr2_-_208031943 0.440 ENST00000421199.1
ENST00000457962.1
 KLF7

Kruppel-like factor 7 (ubiquitous)

chr5_+_135394840 0.409 ENST00000503087.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr4_-_109541539 0.408 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
 RPL34-AS1


RPL34 antisense RNA 1 (head to head)


chr12_+_15699286 0.406 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr13_-_99667960 0.404 ENST00000448493.2
 DOCK9
dedicator of cytokinesis 9
chr17_-_39150385 0.403 ENST00000391586.1
 KRTAP3-3
keratin associated protein 3-3
chr12_-_54813229 0.393 ENST00000293379.4
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.6 GO:0097338 response to clozapine(GO:0097338)
0.0 0.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.5 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.5 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.4 GO:0014877 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.4 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.3 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.3 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0016015 morphogen activity(GO:0016015)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.2 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases