Motif ID: PITX1

Z-value: 1.313


Transcription factors associated with PITX1:

Gene SymbolEntrez IDGene Name
PITX1 ENSG00000069011.11 PITX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX1hg19_v2_chr5_-_134369973_1343699880.433.4e-02Click!


Activity profile for motif PITX1.

activity profile for motif PITX1


Sorted Z-values histogram for motif PITX1

Sorted Z-values for motif PITX1



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 6.635 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr1_+_151030234 3.705 ENST00000368921.3
 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_153348067 3.187 ENST00000368737.3
 S100A12
S100 calcium binding protein A12
chr2_+_234104079 3.155 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr19_-_55653259 3.052 ENST00000593194.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr6_+_151662815 2.779 ENST00000359755.5
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_113478603 2.602 ENST00000443580.1
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr22_+_30792846 2.442 ENST00000312932.9
ENST00000428195.1
 SEC14L2

SEC14-like 2 (S. cerevisiae)

chr1_+_10290822 2.438 ENST00000377083.1
 KIF1B
kinesin family member 1B
chr7_+_48128194 2.163 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
 UPP1


uridine phosphorylase 1


chr9_+_139847347 2.153 ENST00000371632.3
 LCN12
lipocalin 12
chr19_-_15343773 2.066 ENST00000435261.1
ENST00000594042.1
 EPHX3

epoxide hydrolase 3

chr10_-_7661623 2.006 ENST00000298441.6
 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr19_-_15343191 2.001 ENST00000221730.3
 EPHX3
epoxide hydrolase 3
chr19_-_55652290 1.999 ENST00000589745.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr3_-_111314230 1.998 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr6_-_2903514 1.960 ENST00000380698.4
 SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
chr7_+_100770328 1.917 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr11_-_107729887 1.869 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr11_-_63439381 1.854 ENST00000538786.1
ENST00000540699.1
 ATL3

atlastin GTPase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 473 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.6 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.6 5.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 5.1 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.5 4.6 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 3.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.1 3.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.2 3.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 3.1 GO:0050832 defense response to fungus(GO:0050832)
0.8 3.0 GO:0006218 uridine catabolic process(GO:0006218)
0.0 2.9 GO:0007566 embryo implantation(GO:0007566)
0.9 2.6 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 2.6 GO:0032060 bleb assembly(GO:0032060)
0.1 2.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 2.5 GO:0035803 egg coat formation(GO:0035803)
0.8 2.4 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.6 2.4 GO:1904647 response to rotenone(GO:1904647)
0.3 2.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 2.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 2.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.2 2.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0005925 focal adhesion(GO:0005925)
1.0 7.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 5.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 5.1 GO:0005861 troponin complex(GO:0005861)
0.1 3.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 3.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 3.0 GO:0034774 secretory granule lumen(GO:0034774)
0.0 2.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 2.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 2.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.6 2.4 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.3 2.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 2.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.2 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.9 GO:0045177 apical part of cell(GO:0045177)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.4 1.8 GO:0002081 outer acrosomal membrane(GO:0002081)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 7.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 5.1 GO:0031014 troponin T binding(GO:0031014)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.5 4.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 3.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 3.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.6 3.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.5 3.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 2.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 2.8 GO:0019894 kinesin binding(GO:0019894)
0.1 2.7 GO:0055103 ligase regulator activity(GO:0055103)
0.9 2.6 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.3 2.5 GO:0032190 acrosin binding(GO:0032190)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.6 2.4 GO:0008431 vitamin E binding(GO:0008431)
0.1 2.3 GO:0001972 retinoic acid binding(GO:0001972)
0.2 2.2 GO:0004568 chitinase activity(GO:0004568)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.7 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 2.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 5.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.0 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 3.4 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 3.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.2 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.0 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.0 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.9 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 1.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines