Motif ID: PITX2

Z-value: 0.474


Transcription factors associated with PITX2:

Gene SymbolEntrez IDGene Name
PITX2 ENSG00000164093.11 PITX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544254_111544270,
hg19_v2_chr4_-_111558135_111558198,
hg19_v2_chr4_-_111563076_111563172		-0.368.9e-02Click!


Activity profile for motif PITX2.

activity profile for motif PITX2


Sorted Z-values histogram for motif PITX2

Sorted Z-values for motif PITX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 57 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34458771 2.054 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr13_-_36429763 2.038 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr11_-_5248294 1.697 ENST00000335295.4
 HBB
hemoglobin, beta
chr6_-_111804905 0.862 ENST00000358835.3
ENST00000435970.1
 REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr16_-_5116025 0.796 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
 C16orf89



chromosome 16 open reading frame 89



chr3_+_119421849 0.730 ENST00000273390.5
ENST00000463700.1
 MAATS1

MYCBP-associated, testis expressed 1

chr19_-_49843539 0.710 ENST00000602554.1
ENST00000358234.4
 CTC-301O7.4

CTC-301O7.4

chr12_-_90049878 0.671 ENST00000359142.3
 ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049828 0.656 ENST00000261173.2
ENST00000348959.3
 ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr14_+_75988768 0.648 ENST00000286639.6
 BATF
basic leucine zipper transcription factor, ATF-like
chr8_-_27462822 0.641 ENST00000522098.1
 CLU
clusterin
chr10_-_61900762 0.618 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_75017734 0.578 ENST00000532525.1
 ARRB1
arrestin, beta 1
chr10_-_49482907 0.463 ENST00000374201.3
ENST00000407470.4
 FRMPD2

FERM and PDZ domain containing 2

chr8_-_10512569 0.462 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr14_+_75988851 0.435 ENST00000555504.1
 BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_201979645 0.402 ENST00000367284.5
ENST00000367283.3
 ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_-_165414414 0.374 ENST00000359842.5
 RXRG
retinoid X receptor, gamma
chr11_-_119217365 0.365 ENST00000445041.2
ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
 C1QTNF5
MFRP


C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein


chr19_-_51893827 0.364 ENST00000574814.1
 CTD-2616J11.4
chromosome 19 open reading frame 84

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 2.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 1.7 GO:0030185 nitric oxide transport(GO:0030185)
0.2 1.3 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 1.1 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.2 0.6 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.6 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.4 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.2 GO:0072554 blood vessel lumenization(GO:0072554)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0036157 outer dynein arm(GO:0036157)
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 0.7 GO:0001534 radial spoke(GO:0001534)
0.0 0.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.0 1.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway