Motif ID: PITX3
Z-value: 1.005
Transcription factors associated with PITX3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PITX3 | ENSG00000107859.5 | PITX3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | -0.04 | 8.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 392 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0070268 | cornification(GO:0070268) |
| 0.3 | 2.5 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.1 | 2.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 2.2 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.7 | 2.1 | GO:1904170 | regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172) |
| 0.0 | 2.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.2 | 2.0 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.0 | 2.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.2 | 1.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.0 | 1.8 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.2 | 1.5 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.2 | 1.4 | GO:1990034 | cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034) |
| 0.0 | 1.3 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 1.3 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 1.3 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.0 | 1.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.2 | GO:0005980 | glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 1.2 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.0 | 1.2 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.3 | 1.1 | GO:0061743 | motor learning(GO:0061743) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 142 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 3.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 2.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 2.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 2.1 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.2 | 1.8 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 1.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.3 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 1.3 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 1.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 1.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 1.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.3 | 1.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 1.2 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 1.0 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 1.0 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 1.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 257 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 2.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 2.0 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 1.8 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 1.4 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 1.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 1.3 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.1 | 1.2 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 1.2 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 1.2 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.2 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.0 | 1.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.0 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.2 | 0.9 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.2 | 0.8 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.8 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 0.8 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.0 | 0.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.8 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in C2:CP category:
Showing 1 to 19 of 19 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 3.5 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 1.5 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.0 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.0 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.5 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.4 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.4 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.3 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.3 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.2 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.2 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.2 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.1 | PID_IL5_PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 60 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.4 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 3.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.4 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.1 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 2.0 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.3 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 1.2 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.2 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 1.1 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.1 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.1 | REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.0 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.7 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.7 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.7 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.6 | 0.6 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
