Motif ID: PKNOX1_TGIF2

Z-value: 0.470

Transcription factors associated with PKNOX1_TGIF2:

Gene SymbolEntrez IDGene Name
PKNOX1 ENSG00000160199.10 PKNOX1
TGIF2 ENSG00000118707.5 TGIF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PKNOX1hg19_v2_chr21_+_44394620_443947370.424.2e-02Click!
TGIF2hg19_v2_chr20_+_35202909_35203075-0.281.8e-01Click!


Activity profile for motif PKNOX1_TGIF2.

activity profile for motif PKNOX1_TGIF2


Sorted Z-values histogram for motif PKNOX1_TGIF2

Sorted Z-values for motif PKNOX1_TGIF2



Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_39564993 1.330 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr21_-_34185944 1.095 ENST00000479548.1
 C21orf62
chromosome 21 open reading frame 62
chr11_+_827553 1.039 ENST00000528542.2
ENST00000450448.1
 EFCAB4A

EF-hand calcium binding domain 4A

chr17_+_68071458 0.968 ENST00000589377.1
 KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.955 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr6_+_163148973 0.935 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr7_-_99869799 0.835 ENST00000436886.2
 GATS
GATS, stromal antigen 3 opposite strand
chr6_-_24911195 0.725 ENST00000259698.4
 FAM65B
family with sequence similarity 65, member B
chr18_+_3449330 0.693 ENST00000549253.1
 TGIF1
TGFB-induced factor homeobox 1
chr2_-_74779744 0.545 ENST00000409249.1
 LOXL3
lysyl oxidase-like 3
chr22_+_39052632 0.526 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
 CBY1



chibby homolog 1 (Drosophila)



chr4_-_83483395 0.521 ENST00000515780.2
 TMEM150C
transmembrane protein 150C
chr5_-_132073111 0.512 ENST00000403231.1
 KIF3A
kinesin family member 3A
chr17_+_39405939 0.463 ENST00000334109.2
 KRTAP9-4
keratin associated protein 9-4
chr4_-_149365827 0.461 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr2_-_74780176 0.451 ENST00000409549.1
 LOXL3
lysyl oxidase-like 3
chr19_-_10764509 0.449 ENST00000591501.1
 ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr21_-_34185989 0.447 ENST00000487113.1
ENST00000382373.4
 C21orf62

chromosome 21 open reading frame 62

chr1_+_63989004 0.443 ENST00000371088.4
 EFCAB7
EF-hand calcium binding domain 7
chr19_+_49496705 0.442 ENST00000595090.1
 RUVBL2
RuvB-like AAA ATPase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0010107 potassium ion import(GO:0010107)
0.3 1.0 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 1.0 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.7 GO:1903027 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.1 0.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.6 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.6 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.5 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034)
0.1 0.4 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:0002467 germinal center formation(GO:0002467)
0.0 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.0 GO:0097255 R2TP complex(GO:0097255)
0.0 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.7 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.2 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.2 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha