Motif ID: PLAGL1

Z-value: 2.210


Transcription factors associated with PLAGL1:

Gene SymbolEntrez IDGene Name
PLAGL1 ENSG00000118495.14 PLAGL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PLAGL1hg19_v2_chr6_-_144329531_1443295460.222.9e-01Click!


Activity profile for motif PLAGL1.

activity profile for motif PLAGL1


Sorted Z-values histogram for motif PLAGL1

Sorted Z-values for motif PLAGL1



Network of associatons between targets according to the STRING database.



First level regulatory network of PLAGL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51472031 6.409 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51504852 5.279 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr19_+_2249308 5.064 ENST00000592877.1
ENST00000221496.4
 AMH

anti-Mullerian hormone

chr19_-_55658687 5.035 ENST00000593046.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr18_+_33877654 4.975 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr2_-_241396131 4.884 ENST00000404327.3
 AC110619.2
Uncharacterized protein
chr12_-_58131931 4.849 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_-_51472222 4.830 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr13_-_20806440 4.587 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr22_+_38071615 4.445 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr19_+_35645817 4.344 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr1_-_20812690 4.275 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_51014460 4.203 ENST00000595669.1
 JOSD2
Josephin domain containing 2
chr17_-_76899275 4.073 ENST00000322630.2
ENST00000586713.1
 DDC8

Protein DDC8 homolog

chr8_+_22022800 4.032 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr19_-_55658281 3.853 ENST00000585321.2
ENST00000587465.2
 TNNT1

troponin T type 1 (skeletal, slow)

chr19_-_51014345 3.851 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2


Josephin domain containing 2


chr4_+_4388805 3.716 ENST00000504171.1
 NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr4_-_103266355 3.676 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_-_1748214 3.670 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
 PXDN


peroxidasin homolog (Drosophila)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,478 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 21.7 GO:0016540 protein autoprocessing(GO:0016540)
1.4 12.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 11.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
1.8 10.8 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.4 10.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.9 10.4 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.6 10.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 9.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.4 9.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
1.8 8.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.5 8.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 7.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 7.7 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.1 7.7 GO:0006910 phagocytosis, recognition(GO:0006910)
1.0 7.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.7 7.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 7.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.9 7.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 7.2 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.1 7.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 469 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 75.1 GO:0005924 cell-substrate adherens junction(GO:0005924)
0.1 30.7 GO:0031012 extracellular matrix(GO:0031012)
0.1 17.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.7 17.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 14.3 GO:0098794 postsynapse(GO:0098794)
0.3 12.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 12.7 GO:0005604 basement membrane(GO:0005604)
1.5 10.8 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 10.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 10.1 GO:0034774 secretory granule lumen(GO:0034774)
0.1 10.0 GO:0001726 ruffle(GO:0001726)
0.2 9.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 9.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 9.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.3 8.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 8.5 GO:0005811 lipid particle(GO:0005811)
0.1 7.8 GO:0030027 lamellipodium(GO:0030027)
0.2 6.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 6.8 GO:0070821 tertiary granule membrane(GO:0070821)
0.3 6.5 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 828 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 78.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 20.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 19.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 18.4 GO:0005179 hormone activity(GO:0005179)
0.1 18.2 GO:0005178 integrin binding(GO:0005178)
0.1 12.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 12.4 GO:0030674 protein binding, bridging(GO:0030674)
0.9 12.2 GO:0031014 troponin T binding(GO:0031014)
0.8 11.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 11.3 GO:0005525 GTP binding(GO:0005525)
0.1 10.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 10.3 GO:0050699 WW domain binding(GO:0050699)
0.2 9.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 9.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 9.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 9.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 8.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 8.8 GO:0051015 actin filament binding(GO:0051015)
0.8 8.5 GO:0004305 ethanolamine kinase activity(GO:0004305)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 57.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 36.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 32.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.3 18.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 16.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 15.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 15.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.2 9.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 8.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4 8.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 8.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 8.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.4 7.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.3 7.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 7.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 7.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 6.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 6.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 6.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 6.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 16.5 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 14.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 13.6 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 13.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 12.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 11.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 11.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 10.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.3 9.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 9.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 9.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 9.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 8.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 8.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 8.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 8.6 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 8.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 7.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 6.9 REACTOME_G1_PHASE Genes involved in G1 Phase