Motif ID: POU1F1

Z-value: 0.516


Transcription factors associated with POU1F1:

Gene SymbolEntrez IDGene Name
POU1F1 ENSG00000064835.6 POU1F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU1F1hg19_v2_chr3_-_87325612_87325654-0.155.0e-01Click!


Activity profile for motif POU1F1.

activity profile for motif POU1F1


Sorted Z-values histogram for motif POU1F1

Sorted Z-values for motif POU1F1



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_13141097 1.272 ENST00000411542.1
 AC011288.2
AC011288.2
chr16_-_30122717 1.241 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr5_+_147691979 0.785 ENST00000274565.4
 SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr1_+_115572415 0.638 ENST00000256592.1
 TSHB
thyroid stimulating hormone, beta
chr17_-_5321549 0.567 ENST00000572809.1
 NUP88
nucleoporin 88kDa
chr10_+_94352956 0.526 ENST00000260731.3
 KIF11
kinesin family member 11
chr8_-_91095099 0.518 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr18_-_59274139 0.477 ENST00000586949.1
 RP11-879F14.2
RP11-879F14.2
chr9_+_125133315 0.440 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr4_-_159956333 0.390 ENST00000434826.2
 C4orf45
chromosome 4 open reading frame 45
chr1_-_205391178 0.390 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr1_+_192127578 0.384 ENST00000367460.3
 RGS18
regulator of G-protein signaling 18
chr1_-_197036364 0.378 ENST00000367412.1
 F13B
coagulation factor XIII, B polypeptide
chr19_-_43969796 0.378 ENST00000244333.3
 LYPD3
LY6/PLAUR domain containing 3
chr18_+_29027696 0.369 ENST00000257189.4
 DSG3
desmoglein 3
chr10_+_52152766 0.357 ENST00000596442.1
 AC069547.2
Uncharacterized protein
chr2_-_190044480 0.348 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr9_+_18474204 0.341 ENST00000276935.6
 ADAMTSL1
ADAMTS-like 1
chr11_+_35201826 0.326 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)
chr19_-_36001113 0.320 ENST00000434389.1
 DMKN
dermokine

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.1 0.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.6 GO:0033189 response to vitamin A(GO:0033189)
0.1 0.5 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:1903989 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.2 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0032010 phagolysosome(GO:0032010)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0030849 Y chromosome(GO:0000806) autosome(GO:0030849)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.2 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.2 GO:0004802 transketolase activity(GO:0004802)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.1 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.1 REACTOME_OPSINS Genes involved in Opsins