Motif ID: POU2F1

Z-value: 0.924


Transcription factors associated with POU2F1:

Gene SymbolEntrez IDGene Name
POU2F1 ENSG00000143190.17 POU2F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU2F1hg19_v2_chr1_+_167190066_1671901560.827.1e-07Click!


Activity profile for motif POU2F1.

activity profile for motif POU2F1


Sorted Z-values histogram for motif POU2F1

Sorted Z-values for motif POU2F1



Network of associatons between targets according to the STRING database.



First level regulatory network of POU2F1

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_70861647 9.456 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chrX_-_99665262 5.277 ENST00000373034.4
ENST00000255531.7
 PCDH19

protocadherin 19

chr14_-_107078851 4.912 ENST00000390628.2
 IGHV1-58
immunoglobulin heavy variable 1-58
chr12_-_58329819 3.430 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr14_-_21270995 3.088 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
 RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr5_+_140227048 3.073 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr14_-_21270561 3.047 ENST00000412779.2
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr1_+_104293028 3.006 ENST00000370079.3
 AMY1C
amylase, alpha 1C (salivary)
chr3_-_148939835 2.744 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chr4_-_100356551 2.625 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr18_-_24722995 2.393 ENST00000581714.1
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr4_-_100356291 2.365 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr6_+_135502408 2.292 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
 MYB


v-myb avian myeloblastosis viral oncogene homolog


chr14_-_106642049 2.276 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr6_+_135502466 2.257 ENST00000367814.4
 MYB
v-myb avian myeloblastosis viral oncogene homolog
chr1_+_104159999 2.242 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr12_-_58329888 2.040 ENST00000546580.1
 RP11-620J15.3
RP11-620J15.3
chrX_+_57313113 1.934 ENST00000374900.4
 FAAH2
fatty acid amide hydrolase 2
chr11_-_26588634 1.835 ENST00000436318.2
ENST00000281268.8
 MUC15

mucin 15, cell surface associated

chr10_+_91589309 1.830 ENST00000448490.1
 LINC00865
long intergenic non-protein coding RNA 865

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.5 GO:0046541 saliva secretion(GO:0046541)
0.0 8.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 6.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
1.9 5.7 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.7 5.0 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 4.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 2.7 GO:0006825 copper ion transport(GO:0006825)
0.1 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 2.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.9 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.2 1.8 GO:0006600 creatine metabolic process(GO:0006600)
0.0 1.8 GO:0016266 O-glycan processing(GO:0016266)
0.5 1.5 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 1.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.2 GO:0021670 lateral ventricle development(GO:0021670)
0.0 1.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 1.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.5 1.0 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 4.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.4 GO:0072562 blood microparticle(GO:0072562)
0.0 1.9 GO:0005811 lipid particle(GO:0005811)
0.0 1.9 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.2 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.3 1.0 GO:0097224 sperm connecting piece(GO:0097224)
0.2 1.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 0.6 GO:0044753 amphisome(GO:0044753)
0.0 0.5 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 9.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.9 6.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.5 5.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 5.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 4.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 2.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 2.4 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.6 2.2 GO:0016160 amylase activity(GO:0016160)
0.1 1.8 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.6 GO:0030332 cyclin binding(GO:0030332)
0.0 1.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 1.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 1.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 1.0 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.9 GO:0032036 myosin heavy chain binding(GO:0032036)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 4.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 3.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.5 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.0 1.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.0 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha