Motif ID: POU2F2_POU3F1

Z-value: 1.050

Transcription factors associated with POU2F2_POU3F1:

Gene SymbolEntrez IDGene Name
POU2F2 ENSG00000028277.16 POU2F2
POU3F1 ENSG00000185668.5 POU3F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU2F2hg19_v2_chr19_-_42636617_42636632-0.145.0e-01Click!
POU3F1hg19_v2_chr1_-_38512450_385124740.087.2e-01Click!


Activity profile for motif POU2F2_POU3F1.

activity profile for motif POU2F2_POU3F1


Sorted Z-values histogram for motif POU2F2_POU3F1

Sorted Z-values for motif POU2F2_POU3F1



Network of associatons between targets according to the STRING database.



First level regulatory network of POU2F2_POU3F1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_107078851 3.184 ENST00000390628.2
 IGHV1-58
immunoglobulin heavy variable 1-58
chr1_-_149858227 2.787 ENST00000369155.2
 HIST2H2BE
histone cluster 2, H2be
chr9_-_75567962 2.672 ENST00000297785.3
ENST00000376939.1
 ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr3_+_63638339 2.538 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr6_+_26124373 2.228 ENST00000377791.2
ENST00000602637.1
 HIST1H2AC

histone cluster 1, H2ac

chr5_+_36608422 2.056 ENST00000381918.3
 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_44124019 1.929 ENST00000300811.3
 ZNF428
zinc finger protein 428
chr6_+_26217159 1.799 ENST00000303910.2
 HIST1H2AE
histone cluster 1, H2ae
chr16_+_23847267 1.773 ENST00000321728.7
 PRKCB
protein kinase C, beta
chr9_-_84303269 1.703 ENST00000418319.1
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_+_79745746 1.699 ENST00000281127.7
 NRXN3
neurexin 3
chr6_+_27833034 1.658 ENST00000357320.2
 HIST1H2AL
histone cluster 1, H2al
chr16_-_21314360 1.654 ENST00000219599.3
ENST00000576703.1
 CRYM

crystallin, mu

chr1_-_183622442 1.609 ENST00000308641.4
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr18_-_53089723 1.498 ENST00000561992.1
ENST00000562512.2
 TCF4

transcription factor 4

chr6_-_52668605 1.483 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chr14_-_106926724 1.433 ENST00000434710.1
 IGHV3-43
immunoglobulin heavy variable 3-43
chr19_-_17516449 1.384 ENST00000252593.6
 BST2
bone marrow stromal cell antigen 2
chr6_+_27100811 1.369 ENST00000359193.2
 HIST1H2AG
histone cluster 1, H2ag
chr9_+_136325089 1.351 ENST00000291722.7
ENST00000316948.4
ENST00000540581.1
 CACFD1


calcium channel flower domain containing 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0006342 chromatin silencing(GO:0006342)
0.1 6.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 6.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 5.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 3.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.5 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.1 3.3 GO:0060074 synapse maturation(GO:0060074)
0.7 2.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.3 2.1 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.6 1.7 GO:0070666 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 1.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 1.7 GO:2000811 negative regulation of anoikis(GO:2000811)
0.2 1.6 GO:0036343 psychomotor behavior(GO:0036343)
0.1 1.5 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 1.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.5 1.4 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.4 1.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 1.3 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 1.2 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988)
0.0 1.2 GO:0007140 male meiosis(GO:0007140)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.3 GO:0000786 nucleosome(GO:0000786)
0.1 6.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 1.7 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.2 1.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.8 GO:0033269 internode region of axon(GO:0033269)
0.1 0.7 GO:0036128 CatSper complex(GO:0036128)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.4 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 6.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.2 5.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.8 3.9 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 3.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 2.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.4 1.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.4 1.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 0.9 GO:0016160 amylase activity(GO:0016160)
0.2 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 2.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 2.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.1 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels