Motif ID: POU3F3_POU3F4

Z-value: 0.766

Transcription factors associated with POU3F3_POU3F4:

Gene SymbolEntrez IDGene Name
POU3F3 ENSG00000198914.2 POU3F3
POU3F4 ENSG00000196767.4 POU3F4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU3F4hg19_v2_chrX_+_82763265_82763283-0.301.5e-01Click!
POU3F3hg19_v2_chr2_+_105471969_105471969-0.242.6e-01Click!


Activity profile for motif POU3F3_POU3F4.

activity profile for motif POU3F3_POU3F4


Sorted Z-values histogram for motif POU3F3_POU3F4

Sorted Z-values for motif POU3F3_POU3F4



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F3_POU3F4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_104198377 2.986 ENST00000370083.4
 AMY1A
amylase, alpha 1A (salivary)
chr15_-_45670924 2.576 ENST00000396659.3
 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr14_-_21270995 2.251 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
 RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr14_-_21270561 2.204 ENST00000412779.2
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr4_-_16085340 2.174 ENST00000508167.1
 PROM1
prominin 1
chr4_-_16085314 2.168 ENST00000510224.1
 PROM1
prominin 1
chr16_-_21314360 2.044 ENST00000219599.3
ENST00000576703.1
 CRYM

crystallin, mu

chr3_-_112565703 1.978 ENST00000488794.1
 CD200R1L
CD200 receptor 1-like
chr12_+_109785708 1.876 ENST00000310903.5
 MYO1H
myosin IH
chr11_-_26593649 1.835 ENST00000455601.2
 MUC15
mucin 15, cell surface associated
chr18_-_24722995 1.765 ENST00000581714.1
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr11_-_26593677 1.713 ENST00000527569.1
 MUC15
mucin 15, cell surface associated
chr3_-_112564797 1.699 ENST00000398214.1
ENST00000448932.1
 CD200R1L

CD200 receptor 1-like

chr9_+_34458771 1.651 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr12_+_49297899 1.624 ENST00000552942.1
ENST00000320516.4
 CCDC65

coiled-coil domain containing 65

chr15_+_76352178 1.623 ENST00000388942.3
 C15orf27
chromosome 15 open reading frame 27
chr1_-_104238912 1.430 ENST00000330330.5
 AMY1B
amylase, alpha 1B (salivary)
chr1_-_104239076 1.417 ENST00000370080.3
 AMY1B
amylase, alpha 1B (salivary)
chr19_-_14992264 1.309 ENST00000327462.2
 OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr1_-_151345159 1.221 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
 SELENBP1




selenium binding protein 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
1.1 4.3 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0 3.5 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.6 GO:0006600 creatine metabolic process(GO:0006600)
0.0 2.4 GO:0007586 digestion(GO:0007586)
0.1 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 1.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.5 1.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 1.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.3 GO:0072189 ureter development(GO:0072189)
0.2 1.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.0 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.8 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.7 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.6 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.6 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.7 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0045111 intermediate filament(GO:0005882) intermediate filament cytoskeleton(GO:0045111)
0.0 0.3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.5 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 4.3 GO:0042805 actinin binding(GO:0042805)
1.0 4.1 GO:0016160 amylase activity(GO:0016160)
0.1 2.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 2.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 1.8 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 1.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 1.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.2 GO:0008430 selenium binding(GO:0008430)
0.0 1.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.5 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection