Motif ID: POU3F3_POU3F4
Z-value: 0.766
Transcription factors associated with POU3F3_POU3F4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
POU3F3 | ENSG00000198914.2 | POU3F3 |
POU3F4 | ENSG00000196767.4 | POU3F4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
POU3F4 | hg19_v2_chrX_+_82763265_82763283 | -0.30 | 1.5e-01 | Click! |
POU3F3 | hg19_v2_chr2_+_105471969_105471969 | -0.24 | 2.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 4.3 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
0.5 | 1.6 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
0.2 | 2.6 | GO:0006600 | creatine metabolic process(GO:0006600) |
0.2 | 1.1 | GO:0044245 | polysaccharide digestion(GO:0044245) |
0.1 | 2.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.1 | 0.6 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
0.1 | 0.4 | GO:0042495 | central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
0.1 | 0.3 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
0.1 | 0.4 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
0.1 | 0.7 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
0.1 | 0.4 | GO:2000729 | positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
0.1 | 0.3 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
0.1 | 0.2 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
0.1 | 1.7 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.1 | 0.2 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
0.1 | 0.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.1 | 0.2 | GO:0006533 | aspartate catabolic process(GO:0006533) |
0.1 | 0.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.1 | 4.7 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
0.1 | 1.3 | GO:0072189 | ureter development(GO:0072189) |
0.1 | 2.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.0 | 0.3 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
0.0 | 0.4 | GO:0040031 | snRNA modification(GO:0040031) |
0.0 | 0.3 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
0.0 | 1.0 | GO:0019321 | pentose metabolic process(GO:0019321) |
0.0 | 3.5 | GO:0016266 | O-glycan processing(GO:0016266) |
0.0 | 0.5 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
0.0 | 0.3 | GO:0009635 | response to herbicide(GO:0009635) |
0.0 | 0.3 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
0.0 | 0.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.0 | 0.6 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
0.0 | 0.4 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
0.0 | 0.2 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
0.0 | 0.2 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) 'de novo' NAD biosynthetic process(GO:0034627) |
0.0 | 0.1 | GO:0007500 | mesodermal cell fate determination(GO:0007500) negative regulation of intracellular transport of viral material(GO:1901253) |
0.0 | 0.5 | GO:0021794 | thalamus development(GO:0021794) |
0.0 | 0.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.0 | 0.1 | GO:1902567 | negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439) |
0.0 | 0.8 | GO:0045332 | phospholipid translocation(GO:0045332) |
0.0 | 0.1 | GO:0061743 | motor learning(GO:0061743) |
0.0 | 0.6 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
0.0 | 0.1 | GO:2000015 | regulation of determination of dorsal identity(GO:2000015) |
0.0 | 0.3 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
0.0 | 0.2 | GO:0001865 | NK T cell differentiation(GO:0001865) |
0.0 | 0.2 | GO:0010536 | positive regulation of activation of Janus kinase activity(GO:0010536) |
0.0 | 0.1 | GO:0061325 | norepinephrine biosynthetic process(GO:0042421) cell proliferation involved in outflow tract morphogenesis(GO:0061325) |
0.0 | 0.4 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
0.0 | 0.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.0 | 0.1 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
0.0 | 0.1 | GO:0034553 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
0.0 | 0.1 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
0.0 | 0.0 | GO:0045588 | positive regulation of gamma-delta T cell differentiation(GO:0045588) |
0.0 | 0.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.0 | 0.5 | GO:0097320 | membrane tubulation(GO:0097320) |
0.0 | 0.3 | GO:0060856 | establishment of blood-brain barrier(GO:0060856) |
0.0 | 0.1 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
0.0 | 0.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.0 | 0.4 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
0.0 | 0.1 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
0.0 | 1.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
0.0 | 0.2 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.0 | 0.1 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
0.0 | 0.1 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.0 | 0.1 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
0.0 | 1.4 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.4 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 0.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
0.0 | 0.3 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
0.0 | 2.4 | GO:0007586 | digestion(GO:0007586) |
0.0 | 0.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.0 | 0.1 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
0.0 | 0.3 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
0.0 | 0.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
0.0 | 0.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.0 | 0.1 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
0.0 | 0.0 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
0.0 | 0.3 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 4.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.2 | 1.7 | GO:0036157 | outer dynein arm(GO:0036157) |
0.1 | 0.4 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
0.1 | 0.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
0.1 | 0.3 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
0.1 | 0.4 | GO:0002177 | manchette(GO:0002177) |
0.1 | 0.2 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
0.0 | 0.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 0.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.0 | 2.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.2 | GO:0033263 | CORVET complex(GO:0033263) |
0.0 | 0.2 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
0.0 | 0.4 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.3 | GO:0045111 | intermediate filament(GO:0005882) intermediate filament cytoskeleton(GO:0045111) |
0.0 | 0.1 | GO:1990031 | pinceau fiber(GO:1990031) |
0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.0 | 3.3 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 2.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.1 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
0.0 | 0.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.0 | 0.0 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
0.0 | 0.2 | GO:0043235 | receptor complex(GO:0043235) |
0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 0.1 | GO:0061617 | MICOS complex(GO:0061617) |
0.0 | 0.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 1.3 | GO:0035580 | specific granule lumen(GO:0035580) |
0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.1 | GO:0016013 | syntrophin complex(GO:0016013) |
0.0 | 0.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.1 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
0.0 | 0.3 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
0.0 | 1.2 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 4.1 | GO:0016160 | amylase activity(GO:0016160) |
0.6 | 4.5 | GO:0004522 | ribonuclease A activity(GO:0004522) |
0.5 | 2.0 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
0.4 | 1.6 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
0.3 | 1.8 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
0.1 | 0.1 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
0.1 | 1.2 | GO:0008430 | selenium binding(GO:0008430) |
0.1 | 1.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.1 | 0.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 0.6 | GO:0043532 | angiostatin binding(GO:0043532) |
0.1 | 0.3 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
0.1 | 2.6 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
0.1 | 1.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.1 | 0.2 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
0.1 | 4.3 | GO:0042805 | actinin binding(GO:0042805) |
0.1 | 0.4 | GO:0050682 | AF-2 domain binding(GO:0050682) |
0.1 | 0.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
0.1 | 0.3 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
0.1 | 0.2 | GO:0005148 | prolactin receptor binding(GO:0005148) |
0.0 | 0.3 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.0 | 0.3 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
0.0 | 0.4 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.0 | 0.2 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
0.0 | 0.5 | GO:0005549 | odorant binding(GO:0005549) |
0.0 | 0.8 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.2 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.0 | 0.9 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
0.0 | 0.2 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.0 | 0.4 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.4 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.0 | 0.2 | GO:0004046 | aminoacylase activity(GO:0004046) |
0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
0.0 | 0.1 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.0 | 0.3 | GO:0033691 | sialic acid binding(GO:0033691) |
0.0 | 1.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.3 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
0.0 | 0.2 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
0.0 | 0.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 1.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.0 | 0.1 | GO:0017040 | ceramidase activity(GO:0017040) |
0.0 | 0.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.0 | 0.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 0.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
0.0 | 0.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.6 | ST_STAT3_PATHWAY | STAT3 Pathway |
0.0 | 0.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 1.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 3.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.3 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 7.9 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
0.1 | 3.5 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 1.6 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.1 | 2.3 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.0 | 1.1 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.0 | 0.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
0.0 | 1.5 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
0.0 | 0.4 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 1.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.2 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
0.0 | 0.4 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.5 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
0.0 | 0.3 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |