Motif ID: POU4F1_POU4F3

Z-value: 0.614

Transcription factors associated with POU4F1_POU4F3:

Gene SymbolEntrez IDGene Name
POU4F1 ENSG00000152192.6 POU4F1
POU4F3 ENSG00000091010.4 POU4F3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU4F1hg19_v2_chr13_-_79177673_791777010.481.8e-02Click!
POU4F3hg19_v2_chr5_+_145718587_1457186070.272.0e-01Click!


Activity profile for motif POU4F1_POU4F3.

activity profile for motif POU4F1_POU4F3


Sorted Z-values histogram for motif POU4F1_POU4F3

Sorted Z-values for motif POU4F1_POU4F3



Network of associatons between targets according to the STRING database.



First level regulatory network of POU4F1_POU4F3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_31488433 1.304 ENST00000455608.1
 SMTN
smoothelin
chrX_+_65382433 0.818 ENST00000374727.3
 HEPH
hephaestin
chr3_-_74570291 0.817 ENST00000263665.6
 CNTN3
contactin 3 (plasmacytoma associated)
chr15_-_42264702 0.810 ENST00000220325.4
 EHD4
EH-domain containing 4
chr2_-_88285309 0.739 ENST00000420840.2
 RGPD2
RANBP2-like and GRIP domain containing 2
chr9_-_74675521 0.692 ENST00000377024.3
 C9orf57
chromosome 9 open reading frame 57
chr2_+_182850743 0.651 ENST00000409702.1
 PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr18_+_29027696 0.640 ENST00000257189.4
 DSG3
desmoglein 3
chr19_-_18632861 0.616 ENST00000262809.4
 ELL
elongation factor RNA polymerase II
chr20_+_30102231 0.604 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
 HM13




histocompatibility (minor) 13




chr19_+_56368803 0.576 ENST00000587891.1
 NLRP4
NLR family, pyrin domain containing 4
chr1_+_22979474 0.570 ENST00000509305.1
 C1QB
complement component 1, q subcomponent, B chain
chr14_-_101036119 0.521 ENST00000355173.2
 BEGAIN
brain-enriched guanylate kinase-associated
chr12_+_100750846 0.518 ENST00000323346.5
 SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr18_+_47088401 0.513 ENST00000261292.4
ENST00000427224.2
ENST00000580036.1
 LIPG


lipase, endothelial


chr2_+_87135076 0.490 ENST00000409776.2
 RGPD1
RANBP2-like and GRIP domain containing 1
chr3_-_185826855 0.480 ENST00000306376.5
 ETV5
ets variant 5
chr2_+_182850551 0.478 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
 PPP1R1C


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr9_-_34458531 0.459 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
 FAM219A








family with sequence similarity 219, member A








chr9_+_35673853 0.440 ENST00000378357.4
 CA9
carbonic anhydrase IX

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.9 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.8 GO:0006907 pinocytosis(GO:0006907)
0.0 0.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.7 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.6 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 0.6 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 0.5 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 0.5 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.1 0.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.4 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.2 0.6 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.6 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.2 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.7 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.7 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 0.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.9 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains