Motif ID: POU4F2

Z-value: 0.438


Transcription factors associated with POU4F2:

Gene SymbolEntrez IDGene Name
POU4F2 ENSG00000151615.3 POU4F2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_147560046-0.262.2e-01Click!


Activity profile for motif POU4F2.

activity profile for motif POU4F2


Sorted Z-values histogram for motif POU4F2

Sorted Z-values for motif POU4F2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU4F2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_154393260 0.709 ENST00000435029.4
 KIF4B
kinesin family member 4B
chr21_-_31859755 0.656 ENST00000334055.3
 KRTAP19-2
keratin associated protein 19-2
chr1_-_182641367 0.651 ENST00000508450.1
 RGS8
regulator of G-protein signaling 8
chr12_-_89746173 0.650 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr4_+_169013666 0.598 ENST00000359299.3
 ANXA10
annexin A10
chr11_-_107729887 0.440 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr4_-_47983519 0.438 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
 CNGA1


cyclic nucleotide gated channel alpha 1


chr13_-_36050819 0.414 ENST00000379919.4
 MAB21L1
mab-21-like 1 (C. elegans)
chr3_+_121774202 0.387 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86



CD86 molecule



chr4_+_159443090 0.383 ENST00000343542.5
ENST00000470033.1
 RXFP1

relaxin/insulin-like family peptide receptor 1

chr3_+_63428752 0.368 ENST00000295894.5
 SYNPR
synaptoporin
chr7_-_25268104 0.361 ENST00000222674.2
 NPVF
neuropeptide VF precursor
chr21_-_31864275 0.357 ENST00000334063.4
 KRTAP19-3
keratin associated protein 19-3
chr11_+_118175132 0.335 ENST00000361763.4
 CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr6_-_109777128 0.328 ENST00000358807.3
ENST00000358577.3
 MICAL1

microtubule associated monooxygenase, calponin and LIM domain containing 1

chr9_+_125133315 0.319 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr8_-_49833978 0.298 ENST00000020945.1
 SNAI2
snail family zinc finger 2
chr21_-_32185570 0.294 ENST00000329621.4
 KRTAP8-1
keratin associated protein 8-1
chr14_+_42077552 0.277 ENST00000554120.1
 LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr8_-_49834299 0.274 ENST00000396822.1
 SNAI2
snail family zinc finger 2
chr12_-_30887948 0.260 ENST00000433722.2
 CAPRIN2
caprin family member 2
chr20_+_48909240 0.252 ENST00000371639.3
 RP11-290F20.1
RP11-290F20.1
chr4_+_144354644 0.251 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr4_+_169418255 0.243 ENST00000505667.1
ENST00000511948.1
 PALLD

palladin, cytoskeletal associated protein

chr17_-_79623597 0.237 ENST00000574024.1
ENST00000331056.5
 PDE6G

phosphodiesterase 6G, cGMP-specific, rod, gamma

chr2_+_191792376 0.226 ENST00000409428.1
ENST00000409215.1
 GLS

glutaminase

chr6_-_25874440 0.216 ENST00000361703.6
ENST00000397060.4
 SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr9_+_125132803 0.205 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_55221541 0.196 ENST00000555192.1
 SAMD4A
sterile alpha motif domain containing 4A
chr8_+_22857048 0.187 ENST00000251822.6
 RHOBTB2
Rho-related BTB domain containing 2
chr2_-_158300556 0.182 ENST00000264192.3
 CYTIP
cytohesin 1 interacting protein
chr8_-_131399110 0.179 ENST00000521426.1
 ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr20_-_50419055 0.173 ENST00000217086.4
 SALL4
spalt-like transcription factor 4
chr18_+_32455201 0.172 ENST00000590831.2
 DTNA
dystrobrevin, alpha
chr17_-_33390667 0.151 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
 RFFL


ring finger and FYVE-like domain containing E3 ubiquitin protein ligase


chr4_-_10686373 0.151 ENST00000442825.2
 CLNK
cytokine-dependent hematopoietic cell linker
chr16_+_89228757 0.148 ENST00000565008.1
 LINC00304
long intergenic non-protein coding RNA 304
chr2_-_70780572 0.142 ENST00000450929.1
 TGFA
transforming growth factor, alpha
chr1_-_204183071 0.140 ENST00000308302.3
 GOLT1A
golgi transport 1A
chr5_-_140998616 0.138 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
 DIAPH1





diaphanous-related formin 1





chr11_-_125550764 0.137 ENST00000527795.1
 ACRV1
acrosomal vesicle protein 1
chr12_-_7596735 0.133 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
 CD163L1


CD163 molecule-like 1


chr4_-_138453606 0.132 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18



protocadherin 18



chr1_+_50574585 0.130 ENST00000371824.1
ENST00000371823.4
 ELAVL4

ELAV like neuron-specific RNA binding protein 4

chr4_-_10686475 0.130 ENST00000226951.6
 CLNK
cytokine-dependent hematopoietic cell linker
chr5_-_140998481 0.130 ENST00000518047.1
 DIAPH1
diaphanous-related formin 1
chr20_+_56136136 0.129 ENST00000319441.4
ENST00000543666.1
 PCK1

phosphoenolpyruvate carboxykinase 1 (soluble)

chr4_+_169418195 0.125 ENST00000261509.6
ENST00000335742.7
 PALLD

palladin, cytoskeletal associated protein

chr7_-_81399329 0.125 ENST00000453411.1
ENST00000444829.2
 HGF

hepatocyte growth factor (hepapoietin A; scatter factor)

chr17_-_7832753 0.121 ENST00000303790.2
 KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr14_+_32030582 0.120 ENST00000550649.1
ENST00000281081.7
 NUBPL

nucleotide binding protein-like

chr5_+_66300446 0.119 ENST00000261569.7
 MAST4
microtubule associated serine/threonine kinase family member 4
chr8_+_50824233 0.118 ENST00000522124.1
 SNTG1
syntrophin, gamma 1
chr11_+_31531291 0.114 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
 ELP4


elongator acetyltransferase complex subunit 4


chr14_+_23727694 0.113 ENST00000399905.1
ENST00000470456.1
 C14orf164

chromosome 14 open reading frame 164

chr8_+_7738726 0.108 ENST00000314357.3
 DEFB103A
defensin, beta 103A
chr1_+_40506392 0.105 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
 CAP1











CAP, adenylate cyclase-associated protein 1 (yeast)











chr4_+_76481258 0.103 ENST00000311623.4
ENST00000435974.2
 C4orf26

chromosome 4 open reading frame 26

chr19_-_10446449 0.101 ENST00000592439.1
 ICAM3
intercellular adhesion molecule 3
chr11_-_41481135 0.097 ENST00000528697.1
ENST00000530763.1
 LRRC4C

leucine rich repeat containing 4C

chr8_-_7287870 0.089 ENST00000318124.3
 DEFB103B
defensin, beta 103B
chr6_+_12717892 0.087 ENST00000379350.1
 PHACTR1
phosphatase and actin regulator 1
chrX_-_18690210 0.086 ENST00000379984.3
 RS1
retinoschisin 1
chr4_+_159442878 0.084 ENST00000307765.5
ENST00000423548.1
 RXFP1

relaxin/insulin-like family peptide receptor 1

chr13_+_46039037 0.084 ENST00000349995.5
 COG3
component of oligomeric golgi complex 3
chr1_-_193028426 0.081 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
 UCHL5




ubiquitin carboxyl-terminal hydrolase L5




chr17_-_64225508 0.078 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_+_159557637 0.077 ENST00000445224.2
 SCHIP1
schwannomin interacting protein 1
chr1_-_193028621 0.070 ENST00000367455.4
ENST00000367454.1
 UCHL5

ubiquitin carboxyl-terminal hydrolase L5

chr11_-_125550726 0.067 ENST00000315608.3
ENST00000530048.1
 ACRV1

acrosomal vesicle protein 1

chr19_-_7698599 0.064 ENST00000311069.5
 PCP2
Purkinje cell protein 2
chr6_+_130339710 0.064 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr1_-_182640988 0.063 ENST00000367556.1
 RGS8
regulator of G-protein signaling 8
chr6_-_139308777 0.061 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
 REPS1



RALBP1 associated Eps domain containing 1



chr1_-_182641037 0.060 ENST00000483095.2
 RGS8
regulator of G-protein signaling 8
chr9_-_14308004 0.060 ENST00000493697.1
 NFIB
nuclear factor I/B
chr12_-_118797475 0.059 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3


TAO kinase 3


chrX_-_133931164 0.059 ENST00000370790.1
ENST00000298090.6
 FAM122B

family with sequence similarity 122B

chr11_+_73498898 0.056 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr19_-_7697857 0.056 ENST00000598935.1
 PCP2
Purkinje cell protein 2
chr14_+_22356029 0.053 ENST00000390437.2
 TRAV12-2
T cell receptor alpha variable 12-2
chr3_+_115342349 0.050 ENST00000393780.3
 GAP43
growth associated protein 43
chr10_+_18549645 0.049 ENST00000396576.2
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_-_58613323 0.048 ENST00000474531.1
ENST00000465970.1
 FAM107A

family with sequence similarity 107, member A

chr6_+_118869452 0.047 ENST00000357525.5
 PLN
phospholamban
chr10_-_99205607 0.045 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
 EXOSC1





exosome component 1





chr1_-_193028632 0.045 ENST00000421683.1
 UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chrX_+_68835911 0.040 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
 EDA





ectodysplasin A





chr4_-_123542224 0.038 ENST00000264497.3
 IL21
interleukin 21
chrX_+_139791917 0.034 ENST00000607004.1
ENST00000370535.3
 LINC00632

long intergenic non-protein coding RNA 632

chrX_-_106146547 0.033 ENST00000276173.4
ENST00000411805.1
 RIPPLY1

ripply transcriptional repressor 1

chr4_+_141264597 0.033 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
 SCOC


short coiled-coil protein


chr3_-_51909600 0.029 ENST00000446461.1
 IQCF5
IQ motif containing F5
chr6_+_10521574 0.029 ENST00000495262.1
 GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_-_138820624 0.027 ENST00000343505.5
 NHSL1
NHS-like 1
chr10_+_95372289 0.026 ENST00000371447.3
 PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr4_-_169401628 0.025 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
 DDX60L




DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like




chr10_-_73848531 0.022 ENST00000373109.2
 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr14_-_51027838 0.022 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_+_7682694 0.022 ENST00000335186.2
 DEFB106A
defensin, beta 106A
chr1_+_193028552 0.018 ENST00000400968.2
ENST00000432079.1
 TROVE2

TROVE domain family, member 2

chr6_-_89927151 0.016 ENST00000454853.2
 GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr16_-_20416053 0.013 ENST00000302451.4
 PDILT
protein disulfide isomerase-like, testis expressed
chr10_+_99205959 0.011 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
 ZDHHC16



zinc finger, DHHC-type containing 16



chr4_+_159443024 0.009 ENST00000448688.2
 RXFP1
relaxin/insulin-like family peptide receptor 1
chr10_+_99205894 0.006 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
 ZDHHC16



zinc finger, DHHC-type containing 16



chr10_-_73848086 0.005 ENST00000536168.1
 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_-_58295712 0.003 ENST00000317118.8
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_44482979 0.002 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
 SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr7_-_81399438 0.000 ENST00000222390.5
 HGF
hepatocyte growth factor (hepapoietin A; scatter factor)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.4 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.0 GO:1901876 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0030553 cGMP binding(GO:0030553)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway