Motif ID: PPARA

Z-value: 1.091


Transcription factors associated with PPARA:

Gene SymbolEntrez IDGene Name
PPARA ENSG00000186951.12 PPARA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PPARAhg19_v2_chr22_+_46546494_46546525-0.472.1e-02Click!


Activity profile for motif PPARA.

activity profile for motif PPARA


Sorted Z-values histogram for motif PPARA

Sorted Z-values for motif PPARA



Network of associatons between targets according to the STRING database.



First level regulatory network of PPARA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_63638339 8.359 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr3_-_45957088 6.545 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr3_-_45957534 5.131 ENST00000536047.1
 LZTFL1
leucine zipper transcription factor-like 1
chr12_-_25348007 4.727 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr16_-_67427389 4.636 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr9_-_34381536 4.527 ENST00000379126.3
ENST00000379127.1
ENST00000379133.3
 C9orf24


chromosome 9 open reading frame 24


chr9_-_34381511 4.492 ENST00000379124.1
 C9orf24
chromosome 9 open reading frame 24
chr15_+_71145578 4.452 ENST00000544974.2
ENST00000558546.1
 LRRC49

leucine rich repeat containing 49

chr9_+_34458771 3.585 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr2_-_28113217 3.546 ENST00000444339.2
 RBKS
ribokinase
chr1_-_104238912 3.315 ENST00000330330.5
 AMY1B
amylase, alpha 1B (salivary)
chr1_-_104239076 3.279 ENST00000370080.3
 AMY1B
amylase, alpha 1B (salivary)
chr3_-_9994021 2.883 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr4_+_15471489 2.831 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A








coiled-coil and C2 domain containing 2A








chr2_-_27712583 2.830 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
 IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr15_+_43809797 2.775 ENST00000399453.1
ENST00000300231.5
 MAP1A

microtubule-associated protein 1A

chr9_-_117150243 2.699 ENST00000374088.3
 AKNA
AT-hook transcription factor
chr14_-_21492251 2.648 ENST00000554398.1
 NDRG2
NDRG family member 2
chr14_-_21492113 2.641 ENST00000554094.1
 NDRG2
NDRG family member 2
chr16_+_777118 2.575 ENST00000562141.1
 HAGHL
hydroxyacylglutathione hydrolase-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.7 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 6.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 6.1 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 4.2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.3 3.8 GO:0061525 hindgut development(GO:0061525)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 3.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.7 3.5 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 3.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 3.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 2.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 2.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 2.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 2.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 2.3 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.3 2.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 2.2 GO:0010107 potassium ion import(GO:0010107)
0.1 2.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 2.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 2.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0030426 growth cone(GO:0030426)
0.1 5.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 4.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 4.1 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 3.6 GO:0036157 outer dynein arm(GO:0036157)
0.2 3.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.1 3.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.9 2.8 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 2.8 GO:0036038 MKS complex(GO:0036038)
0.1 2.0 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.6 1.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.3 1.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.5 1.5 GO:0072534 perineuronal net(GO:0072534)
0.4 1.4 GO:0031251 PAN complex(GO:0031251)
0.2 1.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.3 GO:0061574 ASAP complex(GO:0061574)
0.1 1.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 5.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 3.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 3.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 3.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 2.3 GO:0016160 amylase activity(GO:0016160)
0.4 2.3 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3 2.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 2.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 2.1 GO:0004386 helicase activity(GO:0004386)
0.0 1.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.6 1.8 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.2 1.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 1.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.6 1.7 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 1.7 GO:0030955 potassium ion binding(GO:0030955)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.8 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.6 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 1.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.4 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 7.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 2.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.2 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.0 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport