Motif ID: PPARD

Z-value: 0.428


Transcription factors associated with PPARD:

Gene SymbolEntrez IDGene Name
PPARD ENSG00000112033.9 PPARD

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310312_35310359-0.771.3e-05Click!


Activity profile for motif PPARD.

activity profile for motif PPARD


Sorted Z-values histogram for motif PPARD

Sorted Z-values for motif PPARD



Network of associatons between targets according to the STRING database.



First level regulatory network of PPARD

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34458771 1.784 ENST00000437363.1
ENST00000242317.4
DNAI1

dynein, axonemal, intermediate chain 1

chr15_+_82555125 1.743 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B



family with sequence similarity 154, member B



chr2_-_28113217 1.288 ENST00000444339.2
RBKS
ribokinase
chr11_+_111169976 1.087 ENST00000398035.2
COLCA2
colorectal cancer associated 2
chr2_+_159651821 0.878 ENST00000309950.3
ENST00000409042.1
DAPL1

death associated protein-like 1

chr5_-_16509101 0.710 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chrX_-_108868390 0.657 ENST00000372101.2
KCNE1L
KCNE1-like
chr2_-_159313214 0.630 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148


coiled-coil domain containing 148


chr11_+_111169565 0.521 ENST00000528846.1
COLCA2
colorectal cancer associated 2
chr2_-_219433014 0.506 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37




ubiquitin specific peptidase 37




chr12_-_56727676 0.503 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2


PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)


chr10_-_94050820 0.461 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr12_-_56727487 0.428 ENST00000548043.1
ENST00000425394.2
PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr7_+_75911902 0.388 ENST00000413003.1
SRRM3
serine/arginine repetitive matrix 3
chr10_-_49459800 0.376 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr17_-_7123021 0.369 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr6_+_143999072 0.348 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2


phosphatase and actin regulator 2


chr4_+_140586922 0.342 ENST00000265498.1
ENST00000506797.1
MGST2

microsomal glutathione S-transferase 2

chr15_+_43885252 0.337 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr12_+_121163538 0.325 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 1.3 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.9 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.9 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.2 0.5 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 0.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.4 GO:0002091 negative regulation of receptor internalization(GO:0002091) regulation of grooming behavior(GO:2000821)
0.0 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.3 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.1 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0036157 outer dynein arm(GO:0036157)
0.2 0.9 GO:0031251 PAN complex(GO:0031251)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.9 GO:0070513 death domain binding(GO:0070513)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.3 GO:0070404 NADH binding(GO:0070404)
0.0 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.2 GO:0001855 complement component C4b binding(GO:0001855)
0.0 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism