Motif ID: PPARD

Z-value: 0.428


Transcription factors associated with PPARD:

Gene SymbolEntrez IDGene Name
PPARD ENSG00000112033.9 PPARD

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310312_35310359-0.771.3e-05Click!


Activity profile for motif PPARD.

activity profile for motif PPARD


Sorted Z-values histogram for motif PPARD

Sorted Z-values for motif PPARD



Network of associatons between targets according to the STRING database.



First level regulatory network of PPARD

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_34458771 1.784 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr15_+_82555125 1.743 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
 FAM154B



family with sequence similarity 154, member B



chr2_-_28113217 1.288 ENST00000444339.2
 RBKS
ribokinase
chr11_+_111169976 1.087 ENST00000398035.2
 COLCA2
colorectal cancer associated 2
chr2_+_159651821 0.878 ENST00000309950.3
ENST00000409042.1
 DAPL1

death associated protein-like 1

chr5_-_16509101 0.710 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B
chrX_-_108868390 0.657 ENST00000372101.2
 KCNE1L
KCNE1-like
chr2_-_159313214 0.630 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
 CCDC148


coiled-coil domain containing 148


chr11_+_111169565 0.521 ENST00000528846.1
 COLCA2
colorectal cancer associated 2
chr2_-_219433014 0.506 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
 USP37




ubiquitin specific peptidase 37




chr12_-_56727676 0.503 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
 PAN2


PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)


chr10_-_94050820 0.461 ENST00000265997.4
 CPEB3
cytoplasmic polyadenylation element binding protein 3
chr12_-_56727487 0.428 ENST00000548043.1
ENST00000425394.2
 PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr7_+_75911902 0.388 ENST00000413003.1
 SRRM3
serine/arginine repetitive matrix 3
chr10_-_49459800 0.376 ENST00000305531.3
 FRMPD2
FERM and PDZ domain containing 2
chr17_-_7123021 0.369 ENST00000399510.2
 DLG4
discs, large homolog 4 (Drosophila)
chr6_+_143999072 0.348 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
 PHACTR2


phosphatase and actin regulator 2


chr4_+_140586922 0.342 ENST00000265498.1
ENST00000506797.1
 MGST2

microsomal glutathione S-transferase 2

chr15_+_43885252 0.337 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
 CKMT1B



creatine kinase, mitochondrial 1B



chr12_+_121163538 0.325 ENST00000242592.4
 ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr15_+_43985084 0.308 ENST00000434505.1
ENST00000411750.1
 CKMT1A

creatine kinase, mitochondrial 1A

chr1_-_109968973 0.303 ENST00000271308.4
ENST00000538610.1
 PSMA5

proteasome (prosome, macropain) subunit, alpha type, 5

chr1_+_43855560 0.297 ENST00000562955.1
 SZT2
seizure threshold 2 homolog (mouse)
chr16_-_4401284 0.265 ENST00000318059.3
 PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr3_-_49314640 0.264 ENST00000436325.1
 C3orf62
chromosome 3 open reading frame 62
chr6_+_33172407 0.263 ENST00000374662.3
 HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr3_+_48507210 0.260 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
 TREX1



three prime repair exonuclease 1



chr1_+_6511651 0.250 ENST00000434576.1
 ESPN
espin
chr9_+_126773880 0.249 ENST00000373615.4
 LHX2
LIM homeobox 2
chr22_-_51016846 0.247 ENST00000312108.7
ENST00000395650.2
 CPT1B

carnitine palmitoyltransferase 1B (muscle)

chr22_+_30163340 0.247 ENST00000330029.6
ENST00000401406.3
 UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr1_-_11107280 0.242 ENST00000400897.3
ENST00000400898.3
 MASP2

mannan-binding lectin serine peptidase 2

chr22_-_51017084 0.230 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
 CPT1B


carnitine palmitoyltransferase 1B (muscle)


chr12_+_131438443 0.227 ENST00000261654.5
 GPR133
G protein-coupled receptor 133
chr14_+_32546274 0.218 ENST00000396582.2
 ARHGAP5
Rho GTPase activating protein 5
chr19_+_10197463 0.216 ENST00000590378.1
ENST00000397881.3
 C19orf66

chromosome 19 open reading frame 66

chr16_-_4401258 0.204 ENST00000577031.1
 PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr9_-_33402506 0.204 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
 AQP7




aquaporin 7




chr11_+_64073699 0.204 ENST00000405666.1
ENST00000468670.1
 ESRRA

estrogen-related receptor alpha

chr17_+_48610074 0.200 ENST00000503690.1
ENST00000514874.1
ENST00000537145.1
ENST00000541226.1
 EPN3



epsin 3



chr20_-_44485835 0.200 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
 ACOT8


acyl-CoA thioesterase 8


chr19_-_3062465 0.199 ENST00000327141.4
 AES
amino-terminal enhancer of split
chr7_-_34978980 0.186 ENST00000428054.1
 DPY19L1
dpy-19-like 1 (C. elegans)
chr1_+_9005917 0.179 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
 CA6




carbonic anhydrase VI




chr2_+_28113583 0.179 ENST00000344773.2
ENST00000379624.1
ENST00000342045.2
ENST00000379632.2
ENST00000361704.2
 BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr1_+_156123318 0.169 ENST00000368285.3
 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr6_+_88299833 0.164 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
 ORC3



origin recognition complex, subunit 3



chr8_-_80942467 0.157 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
 MRPS28


mitochondrial ribosomal protein S28


chr2_-_178257401 0.152 ENST00000464747.1
 NFE2L2
nuclear factor, erythroid 2-like 2
chr19_-_10687907 0.146 ENST00000589348.1
 AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_43855545 0.143 ENST00000372450.4
ENST00000310739.4
 SZT2

seizure threshold 2 homolog (mouse)

chr16_-_74808710 0.142 ENST00000219368.3
ENST00000544337.1
 FA2H

fatty acid 2-hydroxylase

chr20_+_32077880 0.137 ENST00000342704.6
ENST00000375279.2
 CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr14_-_25045446 0.132 ENST00000216336.2
 CTSG
cathepsin G
chr1_-_161039456 0.131 ENST00000368016.3
 ARHGAP30
Rho GTPase activating protein 30
chr3_-_50605077 0.130 ENST00000426034.1
ENST00000441239.1
 C3orf18

chromosome 3 open reading frame 18

chr1_+_244998602 0.128 ENST00000411948.2
 COX20
COX20 cytochrome C oxidase assembly factor
chr2_+_198365095 0.122 ENST00000409468.1
 HSPE1
heat shock 10kDa protein 1
chr11_+_17281900 0.118 ENST00000530527.1
 NUCB2
nucleobindin 2
chr17_+_7123125 0.115 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
 ACADVL


acyl-CoA dehydrogenase, very long chain


chr17_+_73997419 0.114 ENST00000425876.2
 CDK3
cyclin-dependent kinase 3
chr11_+_66624527 0.114 ENST00000393952.3
 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr13_+_113760098 0.114 ENST00000346342.3
ENST00000541084.1
ENST00000375581.3
 F7


coagulation factor VII (serum prothrombin conversion accelerator)


chr19_-_10687983 0.114 ENST00000587069.1
 AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr21_-_27107198 0.109 ENST00000400094.1
 ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr3_-_125094093 0.102 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
 ZNF148






zinc finger protein 148






chr21_-_27107283 0.098 ENST00000284971.3
ENST00000400099.1
 ATP5J

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6

chr1_-_43855479 0.098 ENST00000290663.6
ENST00000372457.4
 MED8

mediator complex subunit 8

chr20_+_39969519 0.095 ENST00000373257.3
 LPIN3
lipin 3
chr2_+_219433281 0.095 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
 RQCD1


RCD1 required for cell differentiation1 homolog (S. pombe)


chr2_+_198365122 0.094 ENST00000604458.1
 HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_-_45939374 0.094 ENST00000533151.1
ENST00000241041.3
 PEX16

peroxisomal biogenesis factor 16

chr8_-_80942061 0.092 ENST00000519386.1
 MRPS28
mitochondrial ribosomal protein S28
chr21_-_27107344 0.091 ENST00000457143.2
 ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr19_+_51273721 0.091 ENST00000270590.4
 GPR32
G protein-coupled receptor 32
chr17_-_4464081 0.084 ENST00000574154.1
 GGT6
gamma-glutamyltransferase 6
chrX_+_2746850 0.084 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
 GYG2


glycogenin 2


chr1_-_120311517 0.084 ENST00000369406.3
ENST00000544913.2
 HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr12_-_21757774 0.081 ENST00000261195.2
 GYS2
glycogen synthase 2 (liver)
chr7_+_24324726 0.081 ENST00000405982.1
 NPY
neuropeptide Y
chr21_-_27107881 0.079 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
 ATP5J


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6


chr9_+_131037623 0.078 ENST00000495313.1
ENST00000372898.2
 SWI5

SWI5 recombination repair homolog (yeast)

chr6_+_30295036 0.075 ENST00000376659.5
ENST00000428555.1
 TRIM39

tripartite motif containing 39

chr5_-_176981417 0.072 ENST00000514747.1
ENST00000443375.2
ENST00000329540.5
 FAM193B


family with sequence similarity 193, member B


chr8_-_80942139 0.069 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
 MRPS28


mitochondrial ribosomal protein S28


chr7_+_143174966 0.063 ENST00000408916.1
 TAS2R41
taste receptor, type 2, member 41
chr2_+_120125245 0.062 ENST00000393103.2
 DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr1_+_202317855 0.062 ENST00000356764.2
 PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr3_-_48936272 0.052 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
 SLC25A20


solute carrier family 25 (carnitine/acylcarnitine translocase), member 20


chr1_-_160832642 0.050 ENST00000368034.4
 CD244
CD244 molecule, natural killer cell receptor 2B4
chr11_-_47470703 0.047 ENST00000298854.2
 RAPSN
receptor-associated protein of the synapse
chr11_-_47470591 0.044 ENST00000524487.1
 RAPSN
receptor-associated protein of the synapse
chr6_+_43265992 0.043 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
 SLC22A7


solute carrier family 22 (organic anion transporter), member 7


chr19_-_10687948 0.043 ENST00000592285.1
 AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_10196981 0.034 ENST00000591813.1
 C19orf66
chromosome 19 open reading frame 66
chr10_-_74714533 0.032 ENST00000373032.3
 PLA2G12B
phospholipase A2, group XIIB
chr4_+_174089904 0.031 ENST00000265000.4
 GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr17_-_34270668 0.029 ENST00000293274.4
 LYZL6
lysozyme-like 6
chr17_-_34270697 0.026 ENST00000585556.1
 LYZL6
lysozyme-like 6
chr6_+_43266063 0.018 ENST00000372574.3
 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr9_+_35042205 0.014 ENST00000312292.5
ENST00000378745.3
 C9orf131

chromosome 9 open reading frame 131

chr15_+_75494214 0.011 ENST00000394987.4
 C15orf39
chromosome 15 open reading frame 39
chr3_-_187009646 0.010 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
 MASP1





mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)





chr17_-_34344991 0.002 ENST00000591423.1
 CCL23
chemokine (C-C motif) ligand 23
chr3_+_186383741 0.001 ENST00000232003.4
 HRG
histidine-rich glycoprotein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0019303 D-ribose catabolic process(GO:0019303)
0.2 0.5 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 1.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:0002091 negative regulation of receptor internalization(GO:0002091) regulation of grooming behavior(GO:2000821)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.2 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0033594 response to vitamin K(GO:0032571) response to hydroxyisoflavone(GO:0033594) response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.1 GO:0070944 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.9 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.9 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0048733 central nervous system myelin maintenance(GO:0032286) sebaceous gland development(GO:0048733)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031251 PAN complex(GO:0031251)
0.2 1.8 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.3 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 1.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 0.2 GO:0001855 complement component C4b binding(GO:0001855)
0.1 0.3 GO:0070404 NADH binding(GO:0070404)
0.0 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.9 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism