Motif ID: PPARG

Z-value: 0.590


Transcription factors associated with PPARG:

Gene SymbolEntrez IDGene Name
PPARG ENSG00000132170.15 PPARG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PPARGhg19_v2_chr3_+_12392971_12392983,
hg19_v2_chr3_+_12329358_12329393,
hg19_v2_chr3_+_12330560_12330579,
hg19_v2_chr3_+_12329397_12329433		-0.368.7e-02Click!


Activity profile for motif PPARG.

activity profile for motif PPARG


Sorted Z-values histogram for motif PPARG

Sorted Z-values for motif PPARG



Network of associatons between targets according to the STRING database.



First level regulatory network of PPARG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_31870927 1.681 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr2_+_120187465 0.799 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr20_+_37434329 0.749 ENST00000299824.1
ENST00000373331.2
 PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr19_+_50016411 0.713 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
 FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr19_+_56717283 0.672 ENST00000376267.1
 ZSCAN5C
zinc finger and SCAN domain containing 5C
chr19_+_49661037 0.658 ENST00000427978.2
 TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr8_-_143857402 0.612 ENST00000523332.1
 LYNX1
Ly6/neurotoxin 1
chr8_-_101348408 0.609 ENST00000519527.1
ENST00000522369.1
 RNF19A

ring finger protein 19A, RBR E3 ubiquitin protein ligase

chr16_-_21289627 0.606 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr1_-_223853348 0.587 ENST00000366872.5
 CAPN8
calpain 8
chr1_-_153433120 0.587 ENST00000368723.3
 S100A7
S100 calcium binding protein A7
chr1_+_67218124 0.587 ENST00000282670.2
 TCTEX1D1
Tctex1 domain containing 1
chr18_+_5238055 0.584 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
 LINC00667


long intergenic non-protein coding RNA 667


chr19_+_49661079 0.564 ENST00000355712.5
 TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr1_-_47407097 0.540 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr7_-_99569468 0.534 ENST00000419575.1
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr15_+_65204075 0.507 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
 ANKDD1A




ankyrin repeat and death domain containing 1A




chr15_+_71145578 0.490 ENST00000544974.2
ENST00000558546.1
 LRRC49

leucine rich repeat containing 49

chr1_+_217804661 0.489 ENST00000366933.4
 SPATA17
spermatogenesis associated 17
chr19_+_49660997 0.489 ENST00000598691.1
ENST00000252826.5
 TRPM4

transient receptor potential cation channel, subfamily M, member 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.7 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.2 1.7 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.1 1.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2 0.7 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.7 GO:0015671 oxygen transport(GO:0015671)
0.0 0.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.5 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.0 0.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.4 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.0 0.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.4 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:0071500 cellular response to nitrosative stress(GO:0071500)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.0 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.0 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0005272 sodium channel activity(GO:0005272)
0.3 1.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.6 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.5 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.5 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 0.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.4 GO:0031014 troponin T binding(GO:0031014)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1