Motif ID: PRDM1

Z-value: 0.550


Transcription factors associated with PRDM1:

Gene SymbolEntrez IDGene Name
PRDM1 ENSG00000057657.10 PRDM1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM1hg19_v2_chr6_+_106534192_106534224-0.602.1e-03Click!


Activity profile for motif PRDM1.

activity profile for motif PRDM1


Sorted Z-values histogram for motif PRDM1

Sorted Z-values for motif PRDM1



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1

PNG image of the network

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Top targets:


Showing 1 to 20 of 190 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_29527702 3.033 ENST00000377050.4
 UBD
ubiquitin D
chr6_+_32821924 1.410 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr11_-_47736896 1.161 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
 AGBL2




ATP/GTP binding protein-like 2




chr17_+_41158742 1.101 ENST00000415816.2
ENST00000438323.2
 IFI35

interferon-induced protein 35

chr8_+_39770803 1.046 ENST00000518237.1
 IDO1
indoleamine 2,3-dioxygenase 1
chr15_+_71184931 1.017 ENST00000560369.1
ENST00000260382.5
 LRRC49

leucine rich repeat containing 49

chr2_+_231191875 0.984 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
 SP140L



SP140 nuclear body protein-like



chr15_+_71185148 0.983 ENST00000443425.2
ENST00000560755.1
 LRRC49

leucine rich repeat containing 49

chr8_-_54436491 0.974 ENST00000426023.1
 RP11-400K9.4
RP11-400K9.4
chr22_-_36556821 0.871 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
 APOL3


apolipoprotein L, 3


chr12_+_6561190 0.866 ENST00000544021.1
ENST00000266556.7
 TAPBPL

TAP binding protein-like

chr1_+_212782012 0.865 ENST00000341491.4
ENST00000366985.1
 ATF3

activating transcription factor 3

chr16_-_67970990 0.733 ENST00000358514.4
 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_49851313 0.727 ENST00000333486.3
 UBA7
ubiquitin-like modifier activating enzyme 7
chr4_-_46996424 0.717 ENST00000264318.3
 GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr5_-_96143796 0.714 ENST00000296754.3
 ERAP1
endoplasmic reticulum aminopeptidase 1
chr16_+_50775948 0.678 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
 CYLD


cylindromatosis (turban tumor syndrome)


chr3_+_69915385 0.648 ENST00000314589.5
 MITF
microphthalmia-associated transcription factor
chr2_+_69240302 0.635 ENST00000303714.4
 ANTXR1
anthrax toxin receptor 1
chr10_+_91589309 0.628 ENST00000448490.1
 LINC00865
long intergenic non-protein coding RNA 865

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.6 3.0 GO:0070842 aggresome assembly(GO:0070842)
0.1 2.0 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5 1.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 1.5 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 1.2 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 1.0 GO:0036269 swimming behavior(GO:0036269)
0.3 0.9 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.3 0.9 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.9 GO:0008542 visual learning(GO:0008542)
0.3 0.8 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.7 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.2 0.6 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.1 0.6 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.6 GO:1900116 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.6 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0016235 aggresome(GO:0016235)
0.3 3.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.5 GO:0097542 ciliary tip(GO:0097542)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.2 1.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.3 0.9 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.8 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.7 GO:0097227 sperm annulus(GO:0097227)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0097386 glial cell projection(GO:0097386)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0070628 proteasome binding(GO:0070628)
0.1 3.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 1.0 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 1.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 0.8 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.1 0.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.2 0.6 GO:0042007 interleukin-18 binding(GO:0042007)
0.1 0.6 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.4 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.2 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.0 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway