Motif ID: PRDM14

Z-value: 0.244


Transcription factors associated with PRDM14:

Gene SymbolEntrez IDGene Name
PRDM14 ENSG00000147596.3 PRDM14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_70983562-0.019.5e-01Click!


Activity profile for motif PRDM14.

activity profile for motif PRDM14


Sorted Z-values histogram for motif PRDM14

Sorted Z-values for motif PRDM14



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM14

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_55866997 0.443 ENST00000360526.3
ENST00000361503.4
 CES1

carboxylesterase 1

chr4_-_103266626 0.195 ENST00000356736.4
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_+_101437487 0.149 ENST00000427413.1
ENST00000542504.1
 NPAS2

neuronal PAS domain protein 2

chr2_-_69098566 0.148 ENST00000295379.1
 BMP10
bone morphogenetic protein 10
chr19_+_49838653 0.134 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
 CD37





CD37 molecule





chr12_-_49351228 0.116 ENST00000541959.1
ENST00000447318.2
 ARF3

ADP-ribosylation factor 3

chrX_+_41193407 0.115 ENST00000457138.2
ENST00000441189.2
 DDX3X

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

chr12_-_49351148 0.093 ENST00000539611.1
ENST00000398092.4
 ARF3
RP11-302B13.5
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr17_-_46691990 0.088 ENST00000576562.1
 HOXB8
homeobox B8
chrX_+_15525426 0.088 ENST00000342014.6
 BMX
BMX non-receptor tyrosine kinase
chr7_-_139763521 0.083 ENST00000263549.3
 PARP12
poly (ADP-ribose) polymerase family, member 12
chr12_-_49351303 0.083 ENST00000256682.4
 ARF3
ADP-ribosylation factor 3
chr6_-_46048116 0.080 ENST00000185206.6
 CLIC5
chloride intracellular channel 5
chr17_+_41924511 0.075 ENST00000377203.4
ENST00000539718.1
ENST00000588884.1
ENST00000293396.8
ENST00000586233.1
 CD300LG




CD300 molecule-like family member g




chr12_+_56325812 0.075 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
 DGKA





diacylglycerol kinase, alpha 80kDa





chr9_+_132099158 0.074 ENST00000444125.1
 RP11-65J3.1
RP11-65J3.1
chr20_-_3154162 0.073 ENST00000360342.3
 LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr17_-_46692287 0.072 ENST00000239144.4
 HOXB8
homeobox B8
chrX_+_119292467 0.071 ENST00000371388.3
 RHOXF2
Rhox homeobox family, member 2
chr1_+_36621529 0.071 ENST00000316156.4
 MAP7D1
MAP7 domain containing 1
chr9_+_132597722 0.070 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
 USP20


ubiquitin specific peptidase 20


chr7_-_124405681 0.070 ENST00000303921.2
 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr19_+_3572758 0.068 ENST00000416526.1
 HMG20B
high mobility group 20B
chr14_+_89290965 0.068 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
 TTC8







tetratricopeptide repeat domain 8







chr22_-_29457832 0.068 ENST00000216071.4
 C22orf31
chromosome 22 open reading frame 31
chr6_+_72926145 0.060 ENST00000425662.2
ENST00000453976.2
 RIMS1

regulating synaptic membrane exocytosis 1

chr7_+_150211918 0.057 ENST00000313543.4
 GIMAP7
GTPase, IMAP family member 7
chr5_+_32710736 0.055 ENST00000415685.2
 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_-_228244013 0.055 ENST00000304568.3
 TM4SF20
transmembrane 4 L six family member 20
chr17_+_39994032 0.052 ENST00000293303.4
ENST00000438813.1
 KLHL10

kelch-like family member 10

chr17_+_47653178 0.051 ENST00000328741.5
 NXPH3
neurexophilin 3
chr5_-_108063949 0.051 ENST00000606054.1
 LINC01023
long intergenic non-protein coding RNA 1023
chr3_-_155394152 0.049 ENST00000494598.1
 PLCH1
phospholipase C, eta 1
chr8_+_110346546 0.047 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
 ENY2


enhancer of yellow 2 homolog (Drosophila)


chr3_-_143567262 0.047 ENST00000474151.1
ENST00000316549.6
 SLC9A9

solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9

chr2_-_192711968 0.046 ENST00000304141.4
 SDPR
serum deprivation response
chr5_+_32711419 0.046 ENST00000265074.8
 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_+_36873677 0.045 ENST00000471200.1
 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr10_+_12171636 0.044 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
 SEC61A2




Sec61 alpha 2 subunit (S. cerevisiae)




chr15_+_63188009 0.041 ENST00000557900.1
 RP11-1069G10.2
RP11-1069G10.2
chr11_-_65625014 0.041 ENST00000534784.1
 CFL1
cofilin 1 (non-muscle)
chr19_+_39109735 0.040 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
 EIF3K








eukaryotic translation initiation factor 3, subunit K








chr3_+_10289707 0.038 ENST00000287652.4
 TATDN2
TatD DNase domain containing 2
chr10_+_12171721 0.038 ENST00000379020.4
ENST00000379017.3
 SEC61A2

Sec61 alpha 2 subunit (S. cerevisiae)

chr19_-_53757941 0.037 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
 ZNF677


zinc finger protein 677


chr11_-_65624415 0.036 ENST00000524553.1
ENST00000527344.1
 CFL1

cofilin 1 (non-muscle)

chr7_-_44580861 0.033 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1



NPC1-like 1



chr4_+_4861385 0.033 ENST00000382723.4
 MSX1
msh homeobox 1
chr3_-_47517302 0.033 ENST00000441517.2
ENST00000545718.1
 SCAP

SREBF chaperone

chr1_+_50571949 0.028 ENST00000357083.4
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr1_-_27216729 0.027 ENST00000431781.2
ENST00000374135.4
 GPN2

GPN-loop GTPase 2

chr17_+_75450075 0.027 ENST00000592951.1
 SEPT9
septin 9
chr1_+_155006300 0.025 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
 DCST1



DC-STAMP domain containing 1



chr20_-_48770174 0.025 ENST00000341698.2
 TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr11_-_46615498 0.024 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
 AMBRA1



autophagy/beclin-1 regulator 1



chr5_-_16936340 0.023 ENST00000507288.1
ENST00000513610.1
 MYO10

myosin X

chr17_-_73775839 0.021 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
 H3F3B




H3 histone, family 3B (H3.3B)




chr11_+_85566422 0.021 ENST00000342404.3
 CCDC83
coiled-coil domain containing 83
chr17_-_19651654 0.021 ENST00000395555.3
 ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr18_+_57567180 0.019 ENST00000316660.6
ENST00000269518.9
 PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

chr2_-_208030647 0.014 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_-_30066233 0.014 ENST00000222803.5
 FKBP14
FK506 binding protein 14, 22 kDa
chr8_-_102216925 0.014 ENST00000517844.1
 ZNF706
zinc finger protein 706
chr11_+_62475130 0.012 ENST00000294117.5
 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr12_-_52967600 0.012 ENST00000549343.1
ENST00000305620.2
 KRT74

keratin 74

chr15_+_69850521 0.012 ENST00000558781.1
 RP11-279F6.1
RP11-279F6.1
chr2_-_145277882 0.012 ENST00000465070.1
ENST00000444559.1
 ZEB2

zinc finger E-box binding homeobox 2

chr1_+_156052354 0.011 ENST00000368301.2
 LMNA
lamin A/C
chr11_-_105892937 0.011 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
 MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chr17_-_19651668 0.010 ENST00000494157.2
ENST00000225740.6
 ALDH3A1

aldehyde dehydrogenase 3 family, member A1

chr1_-_116383322 0.007 ENST00000429731.1
 NHLH2
nescient helix loop helix 2
chr19_-_6279932 0.006 ENST00000252674.7
 MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr17_-_17485731 0.005 ENST00000395783.1
 PEMT
phosphatidylethanolamine N-methyltransferase
chr1_-_31845914 0.003 ENST00000373713.2
 FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_+_81187753 0.003 ENST00000312465.7
ENST00000456523.3
 FGF5

fibroblast growth factor 5

chr17_+_41924536 0.002 ENST00000317310.4
 CD300LG
CD300 molecule-like family member g
chr19_-_49314269 0.001 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
 BCAT2




branched chain amino-acid transaminase 2, mitochondrial




chr3_+_155838337 0.001 ENST00000490337.1
ENST00000389636.5
 KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr14_-_21492251 0.001 ENST00000554398.1
 NDRG2
NDRG family member 2
chr21_+_26934165 0.000 ENST00000456917.1
 MIR155HG
MIR155 host gene (non-protein coding)
chr14_-_21492113 0.000 ENST00000554094.1
 NDRG2
NDRG family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.0 GO:0090427 activation of meiosis(GO:0090427)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane